Effects of inulin-type fructans supplementation on cardiovascular disease risk factors: a protocol for a systematic review and meta-analysis of randomised controlled trials
Introduction This review aims to assess the effects of dietary supplementation with inulin-type fructans (ITF) compared with no supplementation on cardiovascular disease risk factors in adults and assess the quality of trial reporting using the Consolidated Standards of Reporting Trials (CONSORT) an...
Saved in:
| Main Authors: | , , , , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
BMJ Publishing Group
2022-07-01
|
| Series: | BMJ Open |
| Online Access: | https://bmjopen.bmj.com/content/12/7/e058875.full |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832578455358668800 |
|---|---|
| author | Russell J de Souza Lawrence Mbuagbaw John L Sievenpiper Dena Zeraatkar Laura Banfield Vanessa Ha David J A Jenkins Jhalok Ronjan Talukdar Matthew Adam Cooper Lyuba Lyutvyn Rahim Ali Rachel Bierbrier Sabrina Janes Pauline B Darling |
| author_facet | Russell J de Souza Lawrence Mbuagbaw John L Sievenpiper Dena Zeraatkar Laura Banfield Vanessa Ha David J A Jenkins Jhalok Ronjan Talukdar Matthew Adam Cooper Lyuba Lyutvyn Rahim Ali Rachel Bierbrier Sabrina Janes Pauline B Darling |
| author_sort | Russell J de Souza |
| collection | DOAJ |
| description | Introduction This review aims to assess the effects of dietary supplementation with inulin-type fructans (ITF) compared with no supplementation on cardiovascular disease risk factors in adults and assess the quality of trial reporting using the Consolidated Standards of Reporting Trials (CONSORT) and CONSORT for abstract (CONSORT-A) checklists.Methods and analysis We will search randomised controlled trials (RCTs) in MEDLINE, EMBASE, CINAHL, Emcare, AMED and the Cochrane Database of Systematic Reviews from inception to 31 March 2022, without any language restrictions. The RCTs need to administer ITF in adults for at least 2 weeks and assess effects on at least one cardiovascular risk factor. We will exclude RCTs that (1) assessed the postprandial effects of ITF; (2) included pregnant or lactating participants; (3) enrolled participants undergoing treatment that might affect the response to ITF. We will assess the study risk of bias (RoB) using V.2 of the Cochrane RoB tool for RCTs (RoB 2) and the certainty of the evidence using the Grading of Recommendations, Assessment, Development and Evaluations (GRADE) approach. We will pool data using a random-effects model. We will use the χ2 test to compare compliance of CONSORT and CONSORT-A checklists and Poisson regression to identify factors associated with better reporting.Ethics and dissemination Ethics approval is not required for secondary analysis of already published data. We will publish the reviews in a peer-review journal.PROSPERO registration number CRD42019136745. |
| format | Article |
| id | doaj-art-e54f00fc7ba942acae880b4a287ba4f4 |
| institution | Kabale University |
| issn | 2044-6055 |
| language | English |
| publishDate | 2022-07-01 |
| publisher | BMJ Publishing Group |
| record_format | Article |
| series | BMJ Open |
| spelling | doaj-art-e54f00fc7ba942acae880b4a287ba4f42025-01-30T14:00:08ZengBMJ Publishing GroupBMJ Open2044-60552022-07-0112710.1136/bmjopen-2021-058875Effects of inulin-type fructans supplementation on cardiovascular disease risk factors: a protocol for a systematic review and meta-analysis of randomised controlled trialsRussell J de Souza0Lawrence Mbuagbaw1John L Sievenpiper2Dena Zeraatkar3Laura Banfield4Vanessa Ha5David J A Jenkins6Jhalok Ronjan Talukdar7Matthew Adam Cooper8Lyuba Lyutvyn9Rahim Ali10Rachel Bierbrier11Sabrina Janes12Pauline B Darling13assistant professorDepartment of Health Research Methods, Evidence and Impact, McMaster University, Hamilton, Ontario, CanadaDepartment of Nutritional Sciences, Temerty Faculty of Medicine, University of Toronto, Toronto, Ontario, CanadaDepartment of Biomedical Informatics, Harvard Medical School, Boston, Massachusetts, USAFaculty of Health Sciences, McMaster University, Hamilton, Ontario, CanadaSchool of Medicine, Faculty of Health Sciences, Queen`s University, Kingston, Ontario, CanadaDepartment of Medicine, Temerty Faculty of Medicine, University of Toronto, Toronto, Ontario, CanadaDepartment of Health Research Methods, Evidence, and Impact, McMaster University, Hamilton, ON, CanadaDepartment of Medicine, University of Alberta Faculty of Medicine and Dentistry, Edmonton, AB, CanadaDepartment of Health Research Methods, Evidence, and Impact, McMaster University, Hamilton, Ontario, CanadaFaculty of Law (Common Law Section), University of Ottawa, Ottawa, Ontario, CanadaDepartment of Dermatology, McGill University Health Centre, Montreal, Québec, CanadaSt Michael’s Hospital, Toronto, Ontario, CanadaSchool of Nutrition Sciences, University of Ottawa, Ottawa, Ontario, CanadaIntroduction This review aims to assess the effects of dietary supplementation with inulin-type fructans (ITF) compared with no supplementation on cardiovascular disease risk factors in adults and assess the quality of trial reporting using the Consolidated Standards of Reporting Trials (CONSORT) and CONSORT for abstract (CONSORT-A) checklists.Methods and analysis We will search randomised controlled trials (RCTs) in MEDLINE, EMBASE, CINAHL, Emcare, AMED and the Cochrane Database of Systematic Reviews from inception to 31 March 2022, without any language restrictions. The RCTs need to administer ITF in adults for at least 2 weeks and assess effects on at least one cardiovascular risk factor. We will exclude RCTs that (1) assessed the postprandial effects of ITF; (2) included pregnant or lactating participants; (3) enrolled participants undergoing treatment that might affect the response to ITF. We will assess the study risk of bias (RoB) using V.2 of the Cochrane RoB tool for RCTs (RoB 2) and the certainty of the evidence using the Grading of Recommendations, Assessment, Development and Evaluations (GRADE) approach. We will pool data using a random-effects model. We will use the χ2 test to compare compliance of CONSORT and CONSORT-A checklists and Poisson regression to identify factors associated with better reporting.Ethics and dissemination Ethics approval is not required for secondary analysis of already published data. We will publish the reviews in a peer-review journal.PROSPERO registration number CRD42019136745.https://bmjopen.bmj.com/content/12/7/e058875.full |
| spellingShingle | Russell J de Souza Lawrence Mbuagbaw John L Sievenpiper Dena Zeraatkar Laura Banfield Vanessa Ha David J A Jenkins Jhalok Ronjan Talukdar Matthew Adam Cooper Lyuba Lyutvyn Rahim Ali Rachel Bierbrier Sabrina Janes Pauline B Darling Effects of inulin-type fructans supplementation on cardiovascular disease risk factors: a protocol for a systematic review and meta-analysis of randomised controlled trials BMJ Open |
| title | Effects of inulin-type fructans supplementation on cardiovascular disease risk factors: a protocol for a systematic review and meta-analysis of randomised controlled trials |
| title_full | Effects of inulin-type fructans supplementation on cardiovascular disease risk factors: a protocol for a systematic review and meta-analysis of randomised controlled trials |
| title_fullStr | Effects of inulin-type fructans supplementation on cardiovascular disease risk factors: a protocol for a systematic review and meta-analysis of randomised controlled trials |
| title_full_unstemmed | Effects of inulin-type fructans supplementation on cardiovascular disease risk factors: a protocol for a systematic review and meta-analysis of randomised controlled trials |
| title_short | Effects of inulin-type fructans supplementation on cardiovascular disease risk factors: a protocol for a systematic review and meta-analysis of randomised controlled trials |
| title_sort | effects of inulin type fructans supplementation on cardiovascular disease risk factors a protocol for a systematic review and meta analysis of randomised controlled trials |
| url | https://bmjopen.bmj.com/content/12/7/e058875.full |
| work_keys_str_mv | AT russelljdesouza effectsofinulintypefructanssupplementationoncardiovasculardiseaseriskfactorsaprotocolforasystematicreviewandmetaanalysisofrandomisedcontrolledtrials AT lawrencembuagbaw effectsofinulintypefructanssupplementationoncardiovasculardiseaseriskfactorsaprotocolforasystematicreviewandmetaanalysisofrandomisedcontrolledtrials AT johnlsievenpiper effectsofinulintypefructanssupplementationoncardiovasculardiseaseriskfactorsaprotocolforasystematicreviewandmetaanalysisofrandomisedcontrolledtrials AT denazeraatkar effectsofinulintypefructanssupplementationoncardiovasculardiseaseriskfactorsaprotocolforasystematicreviewandmetaanalysisofrandomisedcontrolledtrials AT laurabanfield effectsofinulintypefructanssupplementationoncardiovasculardiseaseriskfactorsaprotocolforasystematicreviewandmetaanalysisofrandomisedcontrolledtrials AT vanessaha effectsofinulintypefructanssupplementationoncardiovasculardiseaseriskfactorsaprotocolforasystematicreviewandmetaanalysisofrandomisedcontrolledtrials AT davidjajenkins effectsofinulintypefructanssupplementationoncardiovasculardiseaseriskfactorsaprotocolforasystematicreviewandmetaanalysisofrandomisedcontrolledtrials AT jhalokronjantalukdar effectsofinulintypefructanssupplementationoncardiovasculardiseaseriskfactorsaprotocolforasystematicreviewandmetaanalysisofrandomisedcontrolledtrials AT matthewadamcooper effectsofinulintypefructanssupplementationoncardiovasculardiseaseriskfactorsaprotocolforasystematicreviewandmetaanalysisofrandomisedcontrolledtrials AT lyubalyutvyn effectsofinulintypefructanssupplementationoncardiovasculardiseaseriskfactorsaprotocolforasystematicreviewandmetaanalysisofrandomisedcontrolledtrials AT rahimali effectsofinulintypefructanssupplementationoncardiovasculardiseaseriskfactorsaprotocolforasystematicreviewandmetaanalysisofrandomisedcontrolledtrials AT rachelbierbrier effectsofinulintypefructanssupplementationoncardiovasculardiseaseriskfactorsaprotocolforasystematicreviewandmetaanalysisofrandomisedcontrolledtrials AT sabrinajanes effectsofinulintypefructanssupplementationoncardiovasculardiseaseriskfactorsaprotocolforasystematicreviewandmetaanalysisofrandomisedcontrolledtrials AT paulinebdarling effectsofinulintypefructanssupplementationoncardiovasculardiseaseriskfactorsaprotocolforasystematicreviewandmetaanalysisofrandomisedcontrolledtrials |