The Gut Microbiota and Irritable Bowel Syndrome: Friend or Foe?
Progress in the understanding of the pathophysiology of irritable bowel syndrome (IBS), once thought to be a purely psychosomatic disease, has advanced considerably and low-grade inflammation and changes in the gut microbiota now feature as potentially important. The human gut harbours a huge microb...
Saved in:
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2012-01-01
|
| Series: | International Journal of Inflammation |
| Online Access: | http://dx.doi.org/10.1155/2012/151085 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1849435354538442752 |
|---|---|
| author | Uday C. Ghoshal Ratnakar Shukla Ujjala Ghoshal Kok-Ann Gwee Siew C. Ng Eamonn M. M. Quigley |
| author_facet | Uday C. Ghoshal Ratnakar Shukla Ujjala Ghoshal Kok-Ann Gwee Siew C. Ng Eamonn M. M. Quigley |
| author_sort | Uday C. Ghoshal |
| collection | DOAJ |
| description | Progress in the understanding of the pathophysiology of irritable bowel syndrome (IBS), once thought to be a purely psychosomatic disease, has advanced considerably and low-grade inflammation and changes in the gut microbiota now feature as potentially important. The human gut harbours a huge microbial ecosystem, which is equipped to perform a variety of functions such as digestion of food, metabolism of drugs, detoxification of toxic compounds, production of essential vitamins, prevention of attachment of pathogenic bacteria to the gut wall, and maintenance of homeostasis in the gastrointestinal tract. A subset of patients with IBS may have a quantitative increase in bacteria in the small bowel (small intestinal bacterial overgrowth). Qualitative changes in gut microbiota have also been associated with IBS. Targeting the gut microbiota using probiotics and antibiotics has emerged as a potentially effective approach to the treatment of this, hitherto enigmatic, functional bowel disorder. The gut microbiota in health, quantitative and qualitative microbiota changes, and therapeutic manipulations targeting the microbiota in patients with IBS are reviewed in this paper. |
| format | Article |
| id | doaj-art-e54c1c7d8c3f4516ae5d40a4e52fb860 |
| institution | Kabale University |
| issn | 2090-8040 2042-0099 |
| language | English |
| publishDate | 2012-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Inflammation |
| spelling | doaj-art-e54c1c7d8c3f4516ae5d40a4e52fb8602025-08-20T03:26:20ZengWileyInternational Journal of Inflammation2090-80402042-00992012-01-01201210.1155/2012/151085151085The Gut Microbiota and Irritable Bowel Syndrome: Friend or Foe?Uday C. Ghoshal0Ratnakar Shukla1Ujjala Ghoshal2Kok-Ann Gwee3Siew C. Ng4Eamonn M. M. Quigley5Department of Gastroenterology, Sanjay Gandhi Postgraduate Institute of Medical Science, Lucknow 226014, IndiaDepartment of Microbiology, Sanjay Gandhi Postgraduate Institute of Medical Science, Lucknow 226014, IndiaDepartment of Microbiology, Sanjay Gandhi Postgraduate Institute of Medical Science, Lucknow 226014, IndiaStomach, Liver and Bowel Clinic, Gleneagles Hospital, SingaporeDepartment of Medicine and Therapeutics, Institute of Digestive Disease, Prince of Wales Hospital, Chinese University of Hong Kong, Hong KongDepartment of Medicine, Alimentary Pharmabiotic Centre, University College Cork, Cork, IrelandProgress in the understanding of the pathophysiology of irritable bowel syndrome (IBS), once thought to be a purely psychosomatic disease, has advanced considerably and low-grade inflammation and changes in the gut microbiota now feature as potentially important. The human gut harbours a huge microbial ecosystem, which is equipped to perform a variety of functions such as digestion of food, metabolism of drugs, detoxification of toxic compounds, production of essential vitamins, prevention of attachment of pathogenic bacteria to the gut wall, and maintenance of homeostasis in the gastrointestinal tract. A subset of patients with IBS may have a quantitative increase in bacteria in the small bowel (small intestinal bacterial overgrowth). Qualitative changes in gut microbiota have also been associated with IBS. Targeting the gut microbiota using probiotics and antibiotics has emerged as a potentially effective approach to the treatment of this, hitherto enigmatic, functional bowel disorder. The gut microbiota in health, quantitative and qualitative microbiota changes, and therapeutic manipulations targeting the microbiota in patients with IBS are reviewed in this paper.http://dx.doi.org/10.1155/2012/151085 |
| spellingShingle | Uday C. Ghoshal Ratnakar Shukla Ujjala Ghoshal Kok-Ann Gwee Siew C. Ng Eamonn M. M. Quigley The Gut Microbiota and Irritable Bowel Syndrome: Friend or Foe? International Journal of Inflammation |
| title | The Gut Microbiota and Irritable Bowel Syndrome: Friend or Foe? |
| title_full | The Gut Microbiota and Irritable Bowel Syndrome: Friend or Foe? |
| title_fullStr | The Gut Microbiota and Irritable Bowel Syndrome: Friend or Foe? |
| title_full_unstemmed | The Gut Microbiota and Irritable Bowel Syndrome: Friend or Foe? |
| title_short | The Gut Microbiota and Irritable Bowel Syndrome: Friend or Foe? |
| title_sort | gut microbiota and irritable bowel syndrome friend or foe |
| url | http://dx.doi.org/10.1155/2012/151085 |
| work_keys_str_mv | AT udaycghoshal thegutmicrobiotaandirritablebowelsyndromefriendorfoe AT ratnakarshukla thegutmicrobiotaandirritablebowelsyndromefriendorfoe AT ujjalaghoshal thegutmicrobiotaandirritablebowelsyndromefriendorfoe AT kokanngwee thegutmicrobiotaandirritablebowelsyndromefriendorfoe AT siewcng thegutmicrobiotaandirritablebowelsyndromefriendorfoe AT eamonnmmquigley thegutmicrobiotaandirritablebowelsyndromefriendorfoe AT udaycghoshal gutmicrobiotaandirritablebowelsyndromefriendorfoe AT ratnakarshukla gutmicrobiotaandirritablebowelsyndromefriendorfoe AT ujjalaghoshal gutmicrobiotaandirritablebowelsyndromefriendorfoe AT kokanngwee gutmicrobiotaandirritablebowelsyndromefriendorfoe AT siewcng gutmicrobiotaandirritablebowelsyndromefriendorfoe AT eamonnmmquigley gutmicrobiotaandirritablebowelsyndromefriendorfoe |