Polycystic Diseases in Visceral Organs
Primary cilia are nonmotile, microtubule-based, antenna-like organelles projecting from the apical surface of most mammalian cells. Elegant studies have established the importance of ciliary structure and function in signal transduction and the sensory roles of cilia in maintaining healthy cellular...
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| Format: | Article |
| Language: | English |
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Wiley
2011-01-01
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| Series: | Obstetrics and Gynecology International |
| Online Access: | http://dx.doi.org/10.1155/2011/609370 |
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| author | Shakila Abdul-Majeed Surya M. Nauli |
| author_facet | Shakila Abdul-Majeed Surya M. Nauli |
| author_sort | Shakila Abdul-Majeed |
| collection | DOAJ |
| description | Primary cilia are nonmotile, microtubule-based, antenna-like organelles projecting from the apical surface of most mammalian cells. Elegant studies have established the importance of ciliary structure and function in signal transduction and the sensory roles of cilia in maintaining healthy cellular state. In particular, dysfunctional cilia have been implicated in a large number of diseases mainly characterized by the presence of fluid-filled cysts in various organs. Aside from polycystic kidney disease (PKD), however, the roles of cilia in polycystic liver disease (PLD), polycystic pancreas disease (PPD), and polycystic ovarian syndrome (PCOS) are still very vague. In addition, although gender and sex hormones are known to regulate cyst formation, their roles in regulating physiological functions of cilia need to be further explored. |
| format | Article |
| id | doaj-art-e53e61c8449149a88e29eb863e32d785 |
| institution | Kabale University |
| issn | 1687-9589 1687-9597 |
| language | English |
| publishDate | 2011-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Obstetrics and Gynecology International |
| spelling | doaj-art-e53e61c8449149a88e29eb863e32d7852025-02-03T01:26:08ZengWileyObstetrics and Gynecology International1687-95891687-95972011-01-01201110.1155/2011/609370609370Polycystic Diseases in Visceral OrgansShakila Abdul-Majeed0Surya M. Nauli1Department of Pharmacology, The University of Toledo, Health Science Campus, HEB 274, 3000 Arlington Avenue, MS 1015, Toledo, OH 43614, USADepartment of Pharmacology, The University of Toledo, Health Science Campus, HEB 274, 3000 Arlington Avenue, MS 1015, Toledo, OH 43614, USAPrimary cilia are nonmotile, microtubule-based, antenna-like organelles projecting from the apical surface of most mammalian cells. Elegant studies have established the importance of ciliary structure and function in signal transduction and the sensory roles of cilia in maintaining healthy cellular state. In particular, dysfunctional cilia have been implicated in a large number of diseases mainly characterized by the presence of fluid-filled cysts in various organs. Aside from polycystic kidney disease (PKD), however, the roles of cilia in polycystic liver disease (PLD), polycystic pancreas disease (PPD), and polycystic ovarian syndrome (PCOS) are still very vague. In addition, although gender and sex hormones are known to regulate cyst formation, their roles in regulating physiological functions of cilia need to be further explored.http://dx.doi.org/10.1155/2011/609370 |
| spellingShingle | Shakila Abdul-Majeed Surya M. Nauli Polycystic Diseases in Visceral Organs Obstetrics and Gynecology International |
| title | Polycystic Diseases in Visceral Organs |
| title_full | Polycystic Diseases in Visceral Organs |
| title_fullStr | Polycystic Diseases in Visceral Organs |
| title_full_unstemmed | Polycystic Diseases in Visceral Organs |
| title_short | Polycystic Diseases in Visceral Organs |
| title_sort | polycystic diseases in visceral organs |
| url | http://dx.doi.org/10.1155/2011/609370 |
| work_keys_str_mv | AT shakilaabdulmajeed polycysticdiseasesinvisceralorgans AT suryamnauli polycysticdiseasesinvisceralorgans |