Biopharmaceutical characterisation of ciprofloxacin-metallic ion interactions: Comparative study into the effect of aluminium, calcium, zinc and iron on drug solubility and dissolution
Ciprofloxacin bioavailability may be reduced when ciprofloxacin is co-administered with metallic ion containing preparations. In our previous study, physicochemical interaction between ciprofloxacin and ferrous sulphate was successfully simulated in vitro. In the present work, comparative in vitro c...
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Sciendo
2014-03-01
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| Series: | Acta Pharmaceutica |
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| Online Access: | http://www.degruyter.com/view/j/acph.2014.64.issue-1/acph-2014-0007/acph-2014-0007.xml?format=INT |
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| author | Stojković Aleksandra Tajber Lidia Paluch Krzysztof J. Djurić Zorica Parojčić Jelena Corrigan Owen I. |
| author_facet | Stojković Aleksandra Tajber Lidia Paluch Krzysztof J. Djurić Zorica Parojčić Jelena Corrigan Owen I. |
| author_sort | Stojković Aleksandra |
| collection | DOAJ |
| description | Ciprofloxacin bioavailability may be reduced when ciprofloxacin is co-administered with metallic ion containing preparations. In our previous study, physicochemical interaction between ciprofloxacin and ferrous sulphate was successfully simulated in vitro. In the present work, comparative in vitro ciprofloxacin solubility and dissolution studies were performed in the reactive media containing aluminium hydroxide, calcium carbonate or zinc sulphate. Solid phases collected from the dissolution vessel with aluminium hydroxide, calcium carbonate and zinc sulphate were investigated for their properties. The results obtained indicate that different types of adducts may form and retard ciprofloxacin solubility and dissolution. In the case of aluminium, no phase changes were observed. The solid phase generated in the presence of calcium carbonate was identified as hydrated ciprofloxacin base. Similarly to iron, a new complex consistent with Zn(SO4)2(Cl)2(ciprofloxacin)2 × nH2O stoichiometry was generated in the presence of relatively high concentrations of ciprofloxacin hydrochloride and zinc sulphate, indicating that small volume dissolution experiments can be useful for biorelevant dissolution tests. |
| format | Article |
| id | doaj-art-e538687c9c3e4e7e90291a815564f533 |
| institution | Kabale University |
| issn | 1330-0075 1846-9558 |
| language | English |
| publishDate | 2014-03-01 |
| publisher | Sciendo |
| record_format | Article |
| series | Acta Pharmaceutica |
| spelling | doaj-art-e538687c9c3e4e7e90291a815564f5332025-02-02T02:26:50ZengSciendoActa Pharmaceutica1330-00751846-95582014-03-01641778810.2478/acph-2014-0007acph-2014-0007Biopharmaceutical characterisation of ciprofloxacin-metallic ion interactions: Comparative study into the effect of aluminium, calcium, zinc and iron on drug solubility and dissolutionStojković AleksandraTajber Lidia0Paluch Krzysztof J.1Djurić Zorica2Parojčić Jelena3Corrigan Owen I.4School of Pharmacy and Pharmaceutical Sciences, Trinity College University of Dublin Dublin 2, IrelandSchool of Pharmacy and Pharmaceutical Sciences, Trinity College University of Dublin Dublin 2, IrelandFaculty of Pharmacy University of Belgrade 11000 Belgrade, SerbiaFaculty of Pharmacy University of Belgrade 11000 Belgrade, SerbiaSchool of Pharmacy and Pharmaceutical Sciences, Trinity College University of Dublin Dublin 2, IrelandCiprofloxacin bioavailability may be reduced when ciprofloxacin is co-administered with metallic ion containing preparations. In our previous study, physicochemical interaction between ciprofloxacin and ferrous sulphate was successfully simulated in vitro. In the present work, comparative in vitro ciprofloxacin solubility and dissolution studies were performed in the reactive media containing aluminium hydroxide, calcium carbonate or zinc sulphate. Solid phases collected from the dissolution vessel with aluminium hydroxide, calcium carbonate and zinc sulphate were investigated for their properties. The results obtained indicate that different types of adducts may form and retard ciprofloxacin solubility and dissolution. In the case of aluminium, no phase changes were observed. The solid phase generated in the presence of calcium carbonate was identified as hydrated ciprofloxacin base. Similarly to iron, a new complex consistent with Zn(SO4)2(Cl)2(ciprofloxacin)2 × nH2O stoichiometry was generated in the presence of relatively high concentrations of ciprofloxacin hydrochloride and zinc sulphate, indicating that small volume dissolution experiments can be useful for biorelevant dissolution tests.http://www.degruyter.com/view/j/acph.2014.64.issue-1/acph-2014-0007/acph-2014-0007.xml?format=INTciprofloxacindissolutiondrug interactionssolubilitysolid state characterisation |
| spellingShingle | Stojković Aleksandra Tajber Lidia Paluch Krzysztof J. Djurić Zorica Parojčić Jelena Corrigan Owen I. Biopharmaceutical characterisation of ciprofloxacin-metallic ion interactions: Comparative study into the effect of aluminium, calcium, zinc and iron on drug solubility and dissolution Acta Pharmaceutica ciprofloxacin dissolution drug interactions solubility solid state characterisation |
| title | Biopharmaceutical characterisation of ciprofloxacin-metallic ion interactions: Comparative study into the effect of aluminium, calcium, zinc and iron on drug solubility and dissolution |
| title_full | Biopharmaceutical characterisation of ciprofloxacin-metallic ion interactions: Comparative study into the effect of aluminium, calcium, zinc and iron on drug solubility and dissolution |
| title_fullStr | Biopharmaceutical characterisation of ciprofloxacin-metallic ion interactions: Comparative study into the effect of aluminium, calcium, zinc and iron on drug solubility and dissolution |
| title_full_unstemmed | Biopharmaceutical characterisation of ciprofloxacin-metallic ion interactions: Comparative study into the effect of aluminium, calcium, zinc and iron on drug solubility and dissolution |
| title_short | Biopharmaceutical characterisation of ciprofloxacin-metallic ion interactions: Comparative study into the effect of aluminium, calcium, zinc and iron on drug solubility and dissolution |
| title_sort | biopharmaceutical characterisation of ciprofloxacin metallic ion interactions comparative study into the effect of aluminium calcium zinc and iron on drug solubility and dissolution |
| topic | ciprofloxacin dissolution drug interactions solubility solid state characterisation |
| url | http://www.degruyter.com/view/j/acph.2014.64.issue-1/acph-2014-0007/acph-2014-0007.xml?format=INT |
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