Small-Cell Type, Poorly Differentiated Neuroendocrine Carcinoma of the Gallbladder: A Case Report and Review of the Literature
The poorly differentiated small-cell type, neuroendocrine carcinoma (NEC) of the gallbladder is a very uncommon subtype of a neuroendocrine tumor of the gastrointestinal tract. Nonsecretory NEC by virtue of its nonspecific and subtle clinical presentation of the tumor is usually diagnosed at an adva...
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| Format: | Article |
| Language: | English |
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Wiley
2019-01-01
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| Series: | Case Reports in Oncological Medicine |
| Online Access: | http://dx.doi.org/10.1155/2019/8968034 |
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| author | Kishore Kumar Hassan Tariq Rafeeq Ahmed Chime Chukwunonso Masooma Niazi Ariyo Ihimoyan |
| author_facet | Kishore Kumar Hassan Tariq Rafeeq Ahmed Chime Chukwunonso Masooma Niazi Ariyo Ihimoyan |
| author_sort | Kishore Kumar |
| collection | DOAJ |
| description | The poorly differentiated small-cell type, neuroendocrine carcinoma (NEC) of the gallbladder is a very uncommon subtype of a neuroendocrine tumor of the gastrointestinal tract. Nonsecretory NEC by virtue of its nonspecific and subtle clinical presentation of the tumor is usually diagnosed at an advance stage with presenting symptoms related to either locally advance disease or from metastatic disease. Though the radiologic imaging does identify the gall bladder cancer, the tumor lacks a specific diagnostic test; therefore, the diagnosis is almost always confirmed on histopathologic and immunohistochemical staining. We present a case of a poorly differentiated, small-cell neuroendocrine tumor of the gallbladder. The patient died within 3 months after the definitive diagnosis was made. Survival from this deadly malignancy can be improved with aggressive surgical treatment followed by chemotherapy and radiotherapy on a case-by-case scenario. The systemic chemotherapy remained the treatment of choice for an unresectable tumor (Chen et al., 2014). |
| format | Article |
| id | doaj-art-e534a1f3a85d4c28b4845e081f8f93f5 |
| institution | OA Journals |
| issn | 2090-6706 2090-6714 |
| language | English |
| publishDate | 2019-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Oncological Medicine |
| spelling | doaj-art-e534a1f3a85d4c28b4845e081f8f93f52025-08-20T02:21:19ZengWileyCase Reports in Oncological Medicine2090-67062090-67142019-01-01201910.1155/2019/89680348968034Small-Cell Type, Poorly Differentiated Neuroendocrine Carcinoma of the Gallbladder: A Case Report and Review of the LiteratureKishore Kumar0Hassan Tariq1Rafeeq Ahmed2Chime Chukwunonso3Masooma Niazi4Ariyo Ihimoyan5Department of Medicine, Bronxcare Health System, Bronx, New York, USADepartment of Medicine, Bronxcare Health System, Bronx, New York, USADepartment of Medicine, Bronxcare Health System, Bronx, New York, USADepartment of Medicine, Bronxcare Health System, Bronx, New York, USADepartment of Pathology, Bronxcare Health System, Bronx, New York, USADepartment of Medicine, Bronxcare Health System, Bronx, New York, USAThe poorly differentiated small-cell type, neuroendocrine carcinoma (NEC) of the gallbladder is a very uncommon subtype of a neuroendocrine tumor of the gastrointestinal tract. Nonsecretory NEC by virtue of its nonspecific and subtle clinical presentation of the tumor is usually diagnosed at an advance stage with presenting symptoms related to either locally advance disease or from metastatic disease. Though the radiologic imaging does identify the gall bladder cancer, the tumor lacks a specific diagnostic test; therefore, the diagnosis is almost always confirmed on histopathologic and immunohistochemical staining. We present a case of a poorly differentiated, small-cell neuroendocrine tumor of the gallbladder. The patient died within 3 months after the definitive diagnosis was made. Survival from this deadly malignancy can be improved with aggressive surgical treatment followed by chemotherapy and radiotherapy on a case-by-case scenario. The systemic chemotherapy remained the treatment of choice for an unresectable tumor (Chen et al., 2014).http://dx.doi.org/10.1155/2019/8968034 |
| spellingShingle | Kishore Kumar Hassan Tariq Rafeeq Ahmed Chime Chukwunonso Masooma Niazi Ariyo Ihimoyan Small-Cell Type, Poorly Differentiated Neuroendocrine Carcinoma of the Gallbladder: A Case Report and Review of the Literature Case Reports in Oncological Medicine |
| title | Small-Cell Type, Poorly Differentiated Neuroendocrine Carcinoma of the Gallbladder: A Case Report and Review of the Literature |
| title_full | Small-Cell Type, Poorly Differentiated Neuroendocrine Carcinoma of the Gallbladder: A Case Report and Review of the Literature |
| title_fullStr | Small-Cell Type, Poorly Differentiated Neuroendocrine Carcinoma of the Gallbladder: A Case Report and Review of the Literature |
| title_full_unstemmed | Small-Cell Type, Poorly Differentiated Neuroendocrine Carcinoma of the Gallbladder: A Case Report and Review of the Literature |
| title_short | Small-Cell Type, Poorly Differentiated Neuroendocrine Carcinoma of the Gallbladder: A Case Report and Review of the Literature |
| title_sort | small cell type poorly differentiated neuroendocrine carcinoma of the gallbladder a case report and review of the literature |
| url | http://dx.doi.org/10.1155/2019/8968034 |
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