Epithelial cell diversity and immune remodeling in bladder cancer progression: insights from single-cell transcriptomics

Epithelial cell diversity and immune remodeling in bladder cancer progression: insights from single-cell transcriptomics

Abstract Background The progression of bladder cancer (BC) from non-muscle-invasive bladder cancer (NMIBC) to muscle-invasive bladder cancer (MIBC) significantly increases disease severity. Although the tumor microenvironment (TME) plays a pivotal role in this process, the heterogeneity of tumor cel...

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Bibliographic Details
Main Authors: Jianpeng Li, Yunzhong Jiang, Minghai Ma, Lu Wang, Minxuan Jing, Zezhong Yang, Mengzhao Zhang, Ke Chen, Jinhai Fan
Format: Article
Language:English
Published: BMC 2025-01-01
Series:Journal of Translational Medicine
Subjects:
TME
MIBC
NMIBC
ScRNA-seq
T cell
Epithelial cell
Online Access:https://doi.org/10.1186/s12967-025-06138-6
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