The association between systemic inflammatory response index and contrast-associated acute kidney injury in patients undergoing elective percutaneous coronary intervention
Background The systemic inflammatory response index (SIRI), served as a novel inflammatory biomarker, is the synthesis of neutrophils, monocytes and lymphocytes.Aims We hypothesized that SIRI has predictive value for contrast-associated acute kidney injury (CA-AKI) and long-term mortality in patient...
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2024-12-01
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| Series: | Renal Failure |
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| Online Access: | https://www.tandfonline.com/doi/10.1080/0886022X.2024.2330621 |
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| author | Jun-Han Chen Li-Wei Zhang Wen-Jia Liang Wei-ze Lin Xiao-Fang Chen Zhi-Jie Lin Chang-Xi Wang Kai-Yang Lin Yan-Song Guo |
| author_facet | Jun-Han Chen Li-Wei Zhang Wen-Jia Liang Wei-ze Lin Xiao-Fang Chen Zhi-Jie Lin Chang-Xi Wang Kai-Yang Lin Yan-Song Guo |
| author_sort | Jun-Han Chen |
| collection | DOAJ |
| description | Background The systemic inflammatory response index (SIRI), served as a novel inflammatory biomarker, is the synthesis of neutrophils, monocytes and lymphocytes.Aims We hypothesized that SIRI has predictive value for contrast-associated acute kidney injury (CA-AKI) and long-term mortality in patients undergoing elective percutaneous coronary intervention (PCI).Methods We retrospectively observed 5685 patients undergoing elective PCI from January 2012 to December 2018. Venous blood samples were collected to obtain the experimental data on the day of admission or the morning of the next day. SIRI = neutrophil count × monocyte count/lymphocyte count. CA-AKI was defined as an increase of 50% or 0.3 mg/dl in SCr from baseline within 48 h after contrast exposure.Results The incidence of CA-AKI was 6.1% (n = 352). The best cutoff value of SIRI for predicting CA-AKI was 1.39, with a sensitivity of 52.3% and a specificity of 67.3%. [AUC: 0.620, 95% confidence interval (CI): 0.590–0.651, p < 0.001]. After adjusting for potential confounders, multivariate analysis showed that the high SIRI group (SIRI > 1.39) was a strong independent predictor of CA-AKI in patients undergoing elective PCI compared with the low SIRI group (SIRI ≤ 1.39) (odds ratio = 1.642, 95% CI: 1.274–2.116, p < 0.001). Additionally, COX regression analysis showed that SIRI > 1.39 was significantly associated with long-term mortality at a median follow-up of 2.8 years. [Hazard ratio (HR)=1.448, 95%CI: 1.188–1.765; p < 0.001]. Besides, Kaplan–Meier survival curve also indicated that the cumulative rate of mortality was considerably higher in the high SIRI group.Conclusions High levels of SIRI are independent predictors of CA-AKI and long-term mortality in patients undergoing elective PCI. |
| format | Article |
| id | doaj-art-e530c5b7795241f7986e0fecf58fab37 |
| institution | Kabale University |
| issn | 0886-022X 1525-6049 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Renal Failure |
| spelling | doaj-art-e530c5b7795241f7986e0fecf58fab372025-01-23T04:17:48ZengTaylor & Francis GroupRenal Failure0886-022X1525-60492024-12-0146110.1080/0886022X.2024.2330621The association between systemic inflammatory response index and contrast-associated acute kidney injury in patients undergoing elective percutaneous coronary interventionJun-Han Chen0Li-Wei Zhang1Wen-Jia Liang2Wei-ze Lin3Xiao-Fang Chen4Zhi-Jie Lin5Chang-Xi Wang6Kai-Yang Lin7Yan-Song Guo8Department of Cardiology, Shengli Clinical Medical College of Fujian Medical University, Fujian Provincial Hospital, Fuzhou, ChinaDepartment of Cardiology, Shengli Clinical Medical College of Fujian Medical University, Fujian Provincial Hospital, Fuzhou, ChinaDepartment of Cardiology, Shengli Clinical Medical College of Fujian Medical University, Fujian Provincial Hospital, Fuzhou, ChinaDepartment of Cardiology, Shengli Clinical Medical College of Fujian Medical University, Fujian Provincial Hospital, Fuzhou, ChinaDepartment of Cardiology, Shengli Clinical Medical College of Fujian Medical University, Fujian Provincial Hospital, Fuzhou, ChinaDepartment of Cardiology, Shengli Clinical Medical College of Fujian Medical University, Fujian Provincial Hospital, Fuzhou, ChinaDepartment of Cardiology, Shengli Clinical Medical College of Fujian Medical University, Fujian Provincial Hospital, Fuzhou, ChinaDepartment of Cardiology, Shengli Clinical Medical College of Fujian Medical University, Fujian Provincial Hospital, Fuzhou, ChinaDepartment of Cardiology, Shengli Clinical Medical College of Fujian Medical University, Fujian Provincial Hospital, Fuzhou, ChinaBackground The systemic inflammatory response index (SIRI), served as a novel inflammatory biomarker, is the synthesis of neutrophils, monocytes and lymphocytes.Aims We hypothesized that SIRI has predictive value for contrast-associated acute kidney injury (CA-AKI) and long-term mortality in patients undergoing elective percutaneous coronary intervention (PCI).Methods We retrospectively observed 5685 patients undergoing elective PCI from January 2012 to December 2018. Venous blood samples were collected to obtain the experimental data on the day of admission or the morning of the next day. SIRI = neutrophil count × monocyte count/lymphocyte count. CA-AKI was defined as an increase of 50% or 0.3 mg/dl in SCr from baseline within 48 h after contrast exposure.Results The incidence of CA-AKI was 6.1% (n = 352). The best cutoff value of SIRI for predicting CA-AKI was 1.39, with a sensitivity of 52.3% and a specificity of 67.3%. [AUC: 0.620, 95% confidence interval (CI): 0.590–0.651, p < 0.001]. After adjusting for potential confounders, multivariate analysis showed that the high SIRI group (SIRI > 1.39) was a strong independent predictor of CA-AKI in patients undergoing elective PCI compared with the low SIRI group (SIRI ≤ 1.39) (odds ratio = 1.642, 95% CI: 1.274–2.116, p < 0.001). Additionally, COX regression analysis showed that SIRI > 1.39 was significantly associated with long-term mortality at a median follow-up of 2.8 years. [Hazard ratio (HR)=1.448, 95%CI: 1.188–1.765; p < 0.001]. Besides, Kaplan–Meier survival curve also indicated that the cumulative rate of mortality was considerably higher in the high SIRI group.Conclusions High levels of SIRI are independent predictors of CA-AKI and long-term mortality in patients undergoing elective PCI.https://www.tandfonline.com/doi/10.1080/0886022X.2024.2330621Systemic inflammatory response indexcontrast-associated acute kidney injurymortalitypercutaneous coronary intervention |
| spellingShingle | Jun-Han Chen Li-Wei Zhang Wen-Jia Liang Wei-ze Lin Xiao-Fang Chen Zhi-Jie Lin Chang-Xi Wang Kai-Yang Lin Yan-Song Guo The association between systemic inflammatory response index and contrast-associated acute kidney injury in patients undergoing elective percutaneous coronary intervention Renal Failure Systemic inflammatory response index contrast-associated acute kidney injury mortality percutaneous coronary intervention |
| title | The association between systemic inflammatory response index and contrast-associated acute kidney injury in patients undergoing elective percutaneous coronary intervention |
| title_full | The association between systemic inflammatory response index and contrast-associated acute kidney injury in patients undergoing elective percutaneous coronary intervention |
| title_fullStr | The association between systemic inflammatory response index and contrast-associated acute kidney injury in patients undergoing elective percutaneous coronary intervention |
| title_full_unstemmed | The association between systemic inflammatory response index and contrast-associated acute kidney injury in patients undergoing elective percutaneous coronary intervention |
| title_short | The association between systemic inflammatory response index and contrast-associated acute kidney injury in patients undergoing elective percutaneous coronary intervention |
| title_sort | association between systemic inflammatory response index and contrast associated acute kidney injury in patients undergoing elective percutaneous coronary intervention |
| topic | Systemic inflammatory response index contrast-associated acute kidney injury mortality percutaneous coronary intervention |
| url | https://www.tandfonline.com/doi/10.1080/0886022X.2024.2330621 |
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