The difference of oropharyngeal microbiome during acute respiratory viral infections in infants and children
Abstract Acute respiratory infections (ARI) with multiple types of viruses are common in infants and children. This study was conducted to assess the difference of oropharyngeal microbiome during acute respiratory viral infection using whole-genome shotgun metagenomic sequencing. The overall taxonom...
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2025-01-01
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| Series: | Communications Biology |
| Online Access: | https://doi.org/10.1038/s42003-025-07559-1 |
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| author | Zeni Wu Mingyue Jiang Mengmeng Jia Jian Sang Qing Wang Yunshao Xu Li Qi Weizhong Yang Luzhao Feng |
| author_facet | Zeni Wu Mingyue Jiang Mengmeng Jia Jian Sang Qing Wang Yunshao Xu Li Qi Weizhong Yang Luzhao Feng |
| author_sort | Zeni Wu |
| collection | DOAJ |
| description | Abstract Acute respiratory infections (ARI) with multiple types of viruses are common in infants and children. This study was conducted to assess the difference of oropharyngeal microbiome during acute respiratory viral infection using whole-genome shotgun metagenomic sequencing. The overall taxonomic alpha diversity did not differ by the types of infected virus. The beta diversity differed by disease severity, disease-related symptoms, and types of infected virus. Nine species had significantly higher abundance in outpatients than in inpatients, with five of them in the genus Achromobacter. Three microbial community types were identified. The prevalence of community type (CT) 1 was higher among patients with influenza virus, enterovirus, and human adenvirus; CT2 was higher among patients with human metapneumovirus; and CT3 was higher among patients with respiratory syncytial virus and human adenvirus infections. Our results suggest that the oropharyngeal microbiome is associated with ARI disease severity, disease-related symptoms, and the types of infected virus. |
| format | Article |
| id | doaj-art-e53073b366f54c39a1a4e9c53968812a |
| institution | Kabale University |
| issn | 2399-3642 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Communications Biology |
| spelling | doaj-art-e53073b366f54c39a1a4e9c53968812a2025-02-02T12:37:09ZengNature PortfolioCommunications Biology2399-36422025-01-01811910.1038/s42003-025-07559-1The difference of oropharyngeal microbiome during acute respiratory viral infections in infants and childrenZeni Wu0Mingyue Jiang1Mengmeng Jia2Jian Sang3Qing Wang4Yunshao Xu5Li Qi6Weizhong Yang7Luzhao Feng8School of Population Medicine and Public Health, Public Health Emergency Management Innovation Center, Chinese Academy of Medical Sciences and Peking Union Medical CollegeKey Laboratory of Pathogen Infection Prevention and Control (Peking Union Medical College), Ministry of EducationKey Laboratory of Pathogen Infection Prevention and Control (Peking Union Medical College), Ministry of EducationDivision of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of HealthSchool of Population Medicine and Public Health, Public Health Emergency Management Innovation Center, Chinese Academy of Medical Sciences and Peking Union Medical CollegeSchool of Population Medicine and Public Health, Public Health Emergency Management Innovation Center, Chinese Academy of Medical Sciences and Peking Union Medical CollegeChongqing Municipal Center for Disease Control and PreventionSchool of Population Medicine and Public Health, Public Health Emergency Management Innovation Center, Chinese Academy of Medical Sciences and Peking Union Medical CollegeSchool of Population Medicine and Public Health, Public Health Emergency Management Innovation Center, Chinese Academy of Medical Sciences and Peking Union Medical CollegeAbstract Acute respiratory infections (ARI) with multiple types of viruses are common in infants and children. This study was conducted to assess the difference of oropharyngeal microbiome during acute respiratory viral infection using whole-genome shotgun metagenomic sequencing. The overall taxonomic alpha diversity did not differ by the types of infected virus. The beta diversity differed by disease severity, disease-related symptoms, and types of infected virus. Nine species had significantly higher abundance in outpatients than in inpatients, with five of them in the genus Achromobacter. Three microbial community types were identified. The prevalence of community type (CT) 1 was higher among patients with influenza virus, enterovirus, and human adenvirus; CT2 was higher among patients with human metapneumovirus; and CT3 was higher among patients with respiratory syncytial virus and human adenvirus infections. Our results suggest that the oropharyngeal microbiome is associated with ARI disease severity, disease-related symptoms, and the types of infected virus.https://doi.org/10.1038/s42003-025-07559-1 |
| spellingShingle | Zeni Wu Mingyue Jiang Mengmeng Jia Jian Sang Qing Wang Yunshao Xu Li Qi Weizhong Yang Luzhao Feng The difference of oropharyngeal microbiome during acute respiratory viral infections in infants and children Communications Biology |
| title | The difference of oropharyngeal microbiome during acute respiratory viral infections in infants and children |
| title_full | The difference of oropharyngeal microbiome during acute respiratory viral infections in infants and children |
| title_fullStr | The difference of oropharyngeal microbiome during acute respiratory viral infections in infants and children |
| title_full_unstemmed | The difference of oropharyngeal microbiome during acute respiratory viral infections in infants and children |
| title_short | The difference of oropharyngeal microbiome during acute respiratory viral infections in infants and children |
| title_sort | difference of oropharyngeal microbiome during acute respiratory viral infections in infants and children |
| url | https://doi.org/10.1038/s42003-025-07559-1 |
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