Nucleic acid-binding KH domain proteins influence a spectrum of biological pathways including as part of membrane-localized complexes
K-Homology domain (KH domain) proteins bind single-stranded nucleic acids, influence protein–protein interactions of proteins that harbor them, and are found in all kingdoms of life. In concert with other functional protein domains KH domains contribute to a variety of critical biological activities...
Saved in:
| Main Authors: | , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2024-12-01
|
| Series: | Journal of Structural Biology: X |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2590152424000114 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1850060784062693376 |
|---|---|
| author | Md Kamrul Hasan L. Jeannine Brady |
| author_facet | Md Kamrul Hasan L. Jeannine Brady |
| author_sort | Md Kamrul Hasan |
| collection | DOAJ |
| description | K-Homology domain (KH domain) proteins bind single-stranded nucleic acids, influence protein–protein interactions of proteins that harbor them, and are found in all kingdoms of life. In concert with other functional protein domains KH domains contribute to a variety of critical biological activities, often within higher order machineries including membrane-localized protein complexes. Eukaryotic KH domain proteins are linked to developmental processes, morphogenesis, and growth regulation, and their aberrant expression is often associated with cancer. Prokaryotic KH domain proteins are involved in integral cellular activities including cell division and protein translocation. Eukaryotic and prokaryotic KH domains share structural features, but are differentiated based on their structural organizations. In this review, we explore the structure/function relationships of known examples of KH domain proteins, and highlight cases in which they function within or at membrane surfaces. We also summarize examples of KH domain proteins that influence bacterial virulence and pathogenesis. We conclude the article by discussing prospective research avenues that could be pursued to better investigate this largely understudied protein category. |
| format | Article |
| id | doaj-art-e527f396c16f49b3a66ea29ebcd8b480 |
| institution | DOAJ |
| issn | 2590-1524 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Journal of Structural Biology: X |
| spelling | doaj-art-e527f396c16f49b3a66ea29ebcd8b4802025-08-20T02:50:27ZengElsevierJournal of Structural Biology: X2590-15242024-12-011010010610.1016/j.yjsbx.2024.100106Nucleic acid-binding KH domain proteins influence a spectrum of biological pathways including as part of membrane-localized complexesMd Kamrul Hasan0L. Jeannine Brady1Department of Oral Biology, University of Florida, Gainesville, FL 32610, USA; Division of Biology, Kansas State University, Manhattan, KS 66506, USADepartment of Oral Biology, University of Florida, Gainesville, FL 32610, USA; Corresponding author at: Department of Oral Biology, University of Florida, P.O. Box 100424, Gainesville, FL 32610, USA.K-Homology domain (KH domain) proteins bind single-stranded nucleic acids, influence protein–protein interactions of proteins that harbor them, and are found in all kingdoms of life. In concert with other functional protein domains KH domains contribute to a variety of critical biological activities, often within higher order machineries including membrane-localized protein complexes. Eukaryotic KH domain proteins are linked to developmental processes, morphogenesis, and growth regulation, and their aberrant expression is often associated with cancer. Prokaryotic KH domain proteins are involved in integral cellular activities including cell division and protein translocation. Eukaryotic and prokaryotic KH domains share structural features, but are differentiated based on their structural organizations. In this review, we explore the structure/function relationships of known examples of KH domain proteins, and highlight cases in which they function within or at membrane surfaces. We also summarize examples of KH domain proteins that influence bacterial virulence and pathogenesis. We conclude the article by discussing prospective research avenues that could be pursued to better investigate this largely understudied protein category.http://www.sciencedirect.com/science/article/pii/S2590152424000114KH domainRNA stabilityBacterial protein translocationMembrane protein complexesProtein-nucleic acid interactions |
| spellingShingle | Md Kamrul Hasan L. Jeannine Brady Nucleic acid-binding KH domain proteins influence a spectrum of biological pathways including as part of membrane-localized complexes Journal of Structural Biology: X KH domain RNA stability Bacterial protein translocation Membrane protein complexes Protein-nucleic acid interactions |
| title | Nucleic acid-binding KH domain proteins influence a spectrum of biological pathways including as part of membrane-localized complexes |
| title_full | Nucleic acid-binding KH domain proteins influence a spectrum of biological pathways including as part of membrane-localized complexes |
| title_fullStr | Nucleic acid-binding KH domain proteins influence a spectrum of biological pathways including as part of membrane-localized complexes |
| title_full_unstemmed | Nucleic acid-binding KH domain proteins influence a spectrum of biological pathways including as part of membrane-localized complexes |
| title_short | Nucleic acid-binding KH domain proteins influence a spectrum of biological pathways including as part of membrane-localized complexes |
| title_sort | nucleic acid binding kh domain proteins influence a spectrum of biological pathways including as part of membrane localized complexes |
| topic | KH domain RNA stability Bacterial protein translocation Membrane protein complexes Protein-nucleic acid interactions |
| url | http://www.sciencedirect.com/science/article/pii/S2590152424000114 |
| work_keys_str_mv | AT mdkamrulhasan nucleicacidbindingkhdomainproteinsinfluenceaspectrumofbiologicalpathwaysincludingaspartofmembranelocalizedcomplexes AT ljeanninebrady nucleicacidbindingkhdomainproteinsinfluenceaspectrumofbiologicalpathwaysincludingaspartofmembranelocalizedcomplexes |