The GABA-Withdrawal Syndrome: A Model of Local Status Epilepticus
The GABA-withdrawal syndrome (GWS) is a model of local status epilepticus following the interruption of a chronic GABA infusion into the rat somatomotor cortex. GWS is characterized by focal epileptic electroencephalographic discharges and associated contralateral myoclonus. In neocorticai slices ob...
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| Format: | Article |
| Language: | English |
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Wiley
2000-01-01
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| Series: | Neural Plasticity |
| Online Access: | http://dx.doi.org/10.1155/NP.2000.9 |
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| _version_ | 1832562087333724160 |
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| author | Carmen Silva-Barrat Jean Champagnat Christian Menini |
| author_facet | Carmen Silva-Barrat Jean Champagnat Christian Menini |
| author_sort | Carmen Silva-Barrat |
| collection | DOAJ |
| description | The GABA-withdrawal syndrome (GWS)
is a model of local status epilepticus following
the interruption of a chronic GABA infusion
into the rat somatomotor cortex. GWS is
characterized by focal epileptic electroencephalographic
discharges and associated contralateral
myoclonus. In neocorticai slices obtained
from GWS rats, most neurons recorded in the
GABA-infused area are pyramidal neurons
presenting bursting properties. The bursts are
induced by white-matter stimulation and/or
intracellular depolarizing current injection
and correlate with a decrease of cellular
sensitivity to GABA, caused by its prolonged
infusion. This effect is related to a calcium
influx that may reduce the GABAA
receptormediated
inward current and is responsible
for the bursting properties. Here we present
evidence for the involvement of calcium- and
NMDA-induced currents in burst genesis. We
also report modulatory effects of noradrenaline
appearing as changes on firing patterns of
bursting and nonbursting cells. Complementary
histochemical data reveal the existence of a
local noradrenergic hyperinnervation and an
ectopic expression of tyrosine hydroxylase
mRNAs in the epileptic zone. |
| format | Article |
| id | doaj-art-e5213b1203b54b58bd61919d45a71424 |
| institution | Kabale University |
| issn | 2090-5904 1687-5443 |
| language | English |
| publishDate | 2000-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Neural Plasticity |
| spelling | doaj-art-e5213b1203b54b58bd61919d45a714242025-02-03T01:23:32ZengWileyNeural Plasticity2090-59041687-54432000-01-0171-291810.1155/NP.2000.9The GABA-Withdrawal Syndrome: A Model of Local Status EpilepticusCarmen Silva-Barrat0Jean Champagnat1Christian Menini2Laboratoire de Génétique de la Neurotransmission et des Processus Neurodégénératifs, UMR 9923, CNRS., Paris 75634 , FranceInstitut Alfred Fessard, CNRS., Gif sur Yvette 91198, FranceLaboratoire de Génétique de la Neurotransmission et des Processus Neurodégénératifs, UMR 9923, CNRS., Paris 75634 , FranceThe GABA-withdrawal syndrome (GWS) is a model of local status epilepticus following the interruption of a chronic GABA infusion into the rat somatomotor cortex. GWS is characterized by focal epileptic electroencephalographic discharges and associated contralateral myoclonus. In neocorticai slices obtained from GWS rats, most neurons recorded in the GABA-infused area are pyramidal neurons presenting bursting properties. The bursts are induced by white-matter stimulation and/or intracellular depolarizing current injection and correlate with a decrease of cellular sensitivity to GABA, caused by its prolonged infusion. This effect is related to a calcium influx that may reduce the GABAA receptormediated inward current and is responsible for the bursting properties. Here we present evidence for the involvement of calcium- and NMDA-induced currents in burst genesis. We also report modulatory effects of noradrenaline appearing as changes on firing patterns of bursting and nonbursting cells. Complementary histochemical data reveal the existence of a local noradrenergic hyperinnervation and an ectopic expression of tyrosine hydroxylase mRNAs in the epileptic zone.http://dx.doi.org/10.1155/NP.2000.9 |
| spellingShingle | Carmen Silva-Barrat Jean Champagnat Christian Menini The GABA-Withdrawal Syndrome: A Model of Local Status Epilepticus Neural Plasticity |
| title | The GABA-Withdrawal Syndrome: A Model of Local Status Epilepticus |
| title_full | The GABA-Withdrawal Syndrome: A Model of Local Status Epilepticus |
| title_fullStr | The GABA-Withdrawal Syndrome: A Model of Local Status Epilepticus |
| title_full_unstemmed | The GABA-Withdrawal Syndrome: A Model of Local Status Epilepticus |
| title_short | The GABA-Withdrawal Syndrome: A Model of Local Status Epilepticus |
| title_sort | gaba withdrawal syndrome a model of local status epilepticus |
| url | http://dx.doi.org/10.1155/NP.2000.9 |
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