Metainflammation in Diabetic Coronary Artery Disease: Emerging Role of Innate and Adaptive Immune Responses
Globally, noncommunicable chronic diseases such as Type-2 Diabetes Mellitus (T2DM) and Coronary Artery Disease (CAD) are posing a major threat to the world. T2DM is known to potentiate CAD which had led to the coining of a new clinical entity named diabetic CAD (DM-CAD), leading to excessive morbidi...
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| Format: | Article |
| Language: | English |
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Wiley
2016-01-01
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| Series: | Journal of Diabetes Research |
| Online Access: | http://dx.doi.org/10.1155/2016/6264149 |
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| author | Vivekanandhan Aravindhan Haridoss Madhumitha |
| author_facet | Vivekanandhan Aravindhan Haridoss Madhumitha |
| author_sort | Vivekanandhan Aravindhan |
| collection | DOAJ |
| description | Globally, noncommunicable chronic diseases such as Type-2 Diabetes Mellitus (T2DM) and Coronary Artery Disease (CAD) are posing a major threat to the world. T2DM is known to potentiate CAD which had led to the coining of a new clinical entity named diabetic CAD (DM-CAD), leading to excessive morbidity and mortality. The synergistic interaction between these two comorbidities is through sterile inflammation which is now being addressed as metabolic inflammation or metainflammation, which plays a pivotal role during both early and late stages of T2DM and also serves as a link between T2DM and CAD. This review summarises the current concepts on the role played by both innate and adaptive immune responses in setting up metainflammation in DM-CAD. More specifically, the role played by innate pattern recognition receptors (PRRs) like Toll-like receptors (TLRs), NOD1-like receptors (NLRs), Rig-1-like receptors (RLRs), and C-type lectin like receptors (CLRs) and metabolic endotoxemia in fuelling metainflammation in DM-CAD would be discussed. Further, the role played by adaptive immune cells (Th1, Th2, Th17, and Th9 cells) in fuelling metainflammation in DM-CAD will also be discussed. |
| format | Article |
| id | doaj-art-e52110a85fca45edb2a448d005dfba0b |
| institution | OA Journals |
| issn | 2314-6745 2314-6753 |
| language | English |
| publishDate | 2016-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Diabetes Research |
| spelling | doaj-art-e52110a85fca45edb2a448d005dfba0b2025-08-20T02:21:19ZengWileyJournal of Diabetes Research2314-67452314-67532016-01-01201610.1155/2016/62641496264149Metainflammation in Diabetic Coronary Artery Disease: Emerging Role of Innate and Adaptive Immune ResponsesVivekanandhan Aravindhan0Haridoss Madhumitha1Department of Genetics, Dr. ALM. PG. IBMS, University of Madras, Chennai 600113, IndiaAU-KBC Research Centre, MIT Campus of Anna University, Chennai 600044, IndiaGlobally, noncommunicable chronic diseases such as Type-2 Diabetes Mellitus (T2DM) and Coronary Artery Disease (CAD) are posing a major threat to the world. T2DM is known to potentiate CAD which had led to the coining of a new clinical entity named diabetic CAD (DM-CAD), leading to excessive morbidity and mortality. The synergistic interaction between these two comorbidities is through sterile inflammation which is now being addressed as metabolic inflammation or metainflammation, which plays a pivotal role during both early and late stages of T2DM and also serves as a link between T2DM and CAD. This review summarises the current concepts on the role played by both innate and adaptive immune responses in setting up metainflammation in DM-CAD. More specifically, the role played by innate pattern recognition receptors (PRRs) like Toll-like receptors (TLRs), NOD1-like receptors (NLRs), Rig-1-like receptors (RLRs), and C-type lectin like receptors (CLRs) and metabolic endotoxemia in fuelling metainflammation in DM-CAD would be discussed. Further, the role played by adaptive immune cells (Th1, Th2, Th17, and Th9 cells) in fuelling metainflammation in DM-CAD will also be discussed.http://dx.doi.org/10.1155/2016/6264149 |
| spellingShingle | Vivekanandhan Aravindhan Haridoss Madhumitha Metainflammation in Diabetic Coronary Artery Disease: Emerging Role of Innate and Adaptive Immune Responses Journal of Diabetes Research |
| title | Metainflammation in Diabetic Coronary Artery Disease: Emerging Role of Innate and Adaptive Immune Responses |
| title_full | Metainflammation in Diabetic Coronary Artery Disease: Emerging Role of Innate and Adaptive Immune Responses |
| title_fullStr | Metainflammation in Diabetic Coronary Artery Disease: Emerging Role of Innate and Adaptive Immune Responses |
| title_full_unstemmed | Metainflammation in Diabetic Coronary Artery Disease: Emerging Role of Innate and Adaptive Immune Responses |
| title_short | Metainflammation in Diabetic Coronary Artery Disease: Emerging Role of Innate and Adaptive Immune Responses |
| title_sort | metainflammation in diabetic coronary artery disease emerging role of innate and adaptive immune responses |
| url | http://dx.doi.org/10.1155/2016/6264149 |
| work_keys_str_mv | AT vivekanandhanaravindhan metainflammationindiabeticcoronaryarterydiseaseemergingroleofinnateandadaptiveimmuneresponses AT haridossmadhumitha metainflammationindiabeticcoronaryarterydiseaseemergingroleofinnateandadaptiveimmuneresponses |