Cell-cycle dependent DNA repair and replication unifies patterns of chromosome instability

Abstract Chromosomal instability (CIN) is pervasive in human tumours and often leads to structural or numerical chromosomal aberrations. Somatic structural variants (SVs) are intimately related to copy number alterations but the two types of variant are often studied independently. Additionally, des...

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Bibliographic Details
Main Authors: Bingxin Lu, Samuel Winnall, William Cross, Chris P. Barnes
Format: Article
Language:English
Published: Nature Portfolio 2025-03-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-025-58245-z
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