Multiscale modeling of drug-induced liver injury from organ to lobule

Multiscale modeling of drug-induced liver injury from organ to lobule

Abstract Drug-induced liver injury poses significant challenges in drug development and in clinical care. This study builds on prior work developing a Human Liver Virtual Twin by creating a Multiscale Computational Fluid Dynamics framework that integrates patient-specific anatomical data to predict...

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Main Authors: Alon Malka-Markovitz, Stelian Camara Dit Pinto, Mohammed Cherkaoui, Steven M. Levine, Sharmila Anandasabapathy, Gagan K. Sood, Sadhna Dhingra, Gao Yujia, John M. Vierling, Nicolas R. Gallo
Format: Article
Language:English
Published: Nature Portfolio 2025-06-01
Series:npj Digital Medicine
Online Access:https://doi.org/10.1038/s41746-025-01736-6
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