Sirolimus for the Treatment of Airway Obstruction due to Indolent T-Lymphoblastic Proliferation
Introduction. Indolent T-lymphoblastic proliferation (iT-LBP) is a rare nonmalignant entity that presents as a proliferation of T-lymphoblasts. We report a first such case with a recurrent laryngeal obstruction presentation that was successfully controlled with Sirolimus. Case presentation. This is...
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| Format: | Article |
| Language: | English |
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Wiley
2019-01-01
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| Series: | Case Reports in Immunology |
| Online Access: | http://dx.doi.org/10.1155/2019/1724083 |
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| author | Eric Moughames Ana P. Kiess Lee M. Akst Antoine Azar |
| author_facet | Eric Moughames Ana P. Kiess Lee M. Akst Antoine Azar |
| author_sort | Eric Moughames |
| collection | DOAJ |
| description | Introduction. Indolent T-lymphoblastic proliferation (iT-LBP) is a rare nonmalignant entity that presents as a proliferation of T-lymphoblasts. We report a first such case with a recurrent laryngeal obstruction presentation that was successfully controlled with Sirolimus. Case presentation. This is the case of a 29-year-old female who presented with a recurrent significant lymphoid hyperplasia in the adenoid and tongue base region as well as a right cervical lymph node. After repeated adenoidectomies and tonsillectomies, and based on pathological and clinical findings she was diagnosed with iT-LBP. Trials of radiotherapy and immunotherapy with cyclosporine and rituximab all failed to control the progression of the disease. Sirolimus was finally able to restrict the growth and improve her symptoms. Conclusion. While It-LBP does not usually require treatment, it is important to report cases in which treatment was crucial for the survival of the patient, and the effective role of Sirolimus in doing so, without any major adverse effects. |
| format | Article |
| id | doaj-art-e516b60eb447474a84e12b01f539cb04 |
| institution | Kabale University |
| issn | 2090-6609 2090-6617 |
| language | English |
| publishDate | 2019-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Immunology |
| spelling | doaj-art-e516b60eb447474a84e12b01f539cb042025-02-03T06:01:38ZengWileyCase Reports in Immunology2090-66092090-66172019-01-01201910.1155/2019/17240831724083Sirolimus for the Treatment of Airway Obstruction due to Indolent T-Lymphoblastic ProliferationEric Moughames0Ana P. Kiess1Lee M. Akst2Antoine Azar3Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USADepartment of Radiation Oncology and Molecular Radiation Sciences, Johns Hopkins University School of Medicine, Baltimore, MD, USADepartment of Otolaryngology-Head and Neck Surgery, Johns Hopkins University School of Medicine, Baltimore, MD, USADepartment of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USAIntroduction. Indolent T-lymphoblastic proliferation (iT-LBP) is a rare nonmalignant entity that presents as a proliferation of T-lymphoblasts. We report a first such case with a recurrent laryngeal obstruction presentation that was successfully controlled with Sirolimus. Case presentation. This is the case of a 29-year-old female who presented with a recurrent significant lymphoid hyperplasia in the adenoid and tongue base region as well as a right cervical lymph node. After repeated adenoidectomies and tonsillectomies, and based on pathological and clinical findings she was diagnosed with iT-LBP. Trials of radiotherapy and immunotherapy with cyclosporine and rituximab all failed to control the progression of the disease. Sirolimus was finally able to restrict the growth and improve her symptoms. Conclusion. While It-LBP does not usually require treatment, it is important to report cases in which treatment was crucial for the survival of the patient, and the effective role of Sirolimus in doing so, without any major adverse effects.http://dx.doi.org/10.1155/2019/1724083 |
| spellingShingle | Eric Moughames Ana P. Kiess Lee M. Akst Antoine Azar Sirolimus for the Treatment of Airway Obstruction due to Indolent T-Lymphoblastic Proliferation Case Reports in Immunology |
| title | Sirolimus for the Treatment of Airway Obstruction due to Indolent T-Lymphoblastic Proliferation |
| title_full | Sirolimus for the Treatment of Airway Obstruction due to Indolent T-Lymphoblastic Proliferation |
| title_fullStr | Sirolimus for the Treatment of Airway Obstruction due to Indolent T-Lymphoblastic Proliferation |
| title_full_unstemmed | Sirolimus for the Treatment of Airway Obstruction due to Indolent T-Lymphoblastic Proliferation |
| title_short | Sirolimus for the Treatment of Airway Obstruction due to Indolent T-Lymphoblastic Proliferation |
| title_sort | sirolimus for the treatment of airway obstruction due to indolent t lymphoblastic proliferation |
| url | http://dx.doi.org/10.1155/2019/1724083 |
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