Mechanisms and Therapeutic Potential of GPX4 in Pain Modulation
Abstract Pain, a complex symptom encompassing both sensory and emotional dimensions, constitutes a significant global public health issue. Oxidative stress is a pivotal factor in the complex pathophysiology of pain, with glutathione peroxidase 4 (GPX4) recognized as a crucial antioxidant enzyme invo...
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| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
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Adis, Springer Healthcare
2024-11-01
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| Series: | Pain and Therapy |
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| Online Access: | https://doi.org/10.1007/s40122-024-00673-8 |
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| _version_ | 1832586094333394944 |
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| author | Shiwen Fan Kaixin Wang Tianhao Zhang Daling Deng Jiwei Shen Bowen Zhao Daan Fu Xiangdong Chen |
| author_facet | Shiwen Fan Kaixin Wang Tianhao Zhang Daling Deng Jiwei Shen Bowen Zhao Daan Fu Xiangdong Chen |
| author_sort | Shiwen Fan |
| collection | DOAJ |
| description | Abstract Pain, a complex symptom encompassing both sensory and emotional dimensions, constitutes a significant global public health issue. Oxidative stress is a pivotal factor in the complex pathophysiology of pain, with glutathione peroxidase 4 (GPX4) recognized as a crucial antioxidant enzyme involved in both antioxidant defense mechanisms and ferroptosis pathways. This review systematically explores GPX4’s functions across various pain models, including neuropathic, inflammatory, low back, and cancer-related pain. Specifically, the focus includes GPX4’s physiological roles, antioxidant defense mechanisms, regulation of ferroptosis, involvement in signal transduction pathways, and metabolic regulation. By summarizing current research, we highlight the potential of GPX4-targeted therapies in pain management. |
| format | Article |
| id | doaj-art-e50baec236d84ae8977b1d63147d6ee8 |
| institution | Kabale University |
| issn | 2193-8237 2193-651X |
| language | English |
| publishDate | 2024-11-01 |
| publisher | Adis, Springer Healthcare |
| record_format | Article |
| series | Pain and Therapy |
| spelling | doaj-art-e50baec236d84ae8977b1d63147d6ee82025-01-26T12:13:55ZengAdis, Springer HealthcarePain and Therapy2193-82372193-651X2024-11-01141214510.1007/s40122-024-00673-8Mechanisms and Therapeutic Potential of GPX4 in Pain ModulationShiwen Fan0Kaixin Wang1Tianhao Zhang2Daling Deng3Jiwei Shen4Bowen Zhao5Daan Fu6Xiangdong Chen7Department of Anesthesiology, Union Hospital, Tongji Medical College, Huazhong University of Science and TechnologyDepartment of Anesthesiology, Union Hospital, Tongji Medical College, Huazhong University of Science and TechnologyDepartment of Anesthesiology, Union Hospital, Tongji Medical College, Huazhong University of Science and TechnologyDepartment of Anesthesiology, Union Hospital, Tongji Medical College, Huazhong University of Science and TechnologyDepartment of Anesthesiology, Union Hospital, Tongji Medical College, Huazhong University of Science and TechnologyDepartment of Anesthesiology, First Affiliated Hospital of Shihezi UniversityDepartment of Anesthesiology, Union Hospital, Tongji Medical College, Huazhong University of Science and TechnologyDepartment of Anesthesiology, Union Hospital, Tongji Medical College, Huazhong University of Science and TechnologyAbstract Pain, a complex symptom encompassing both sensory and emotional dimensions, constitutes a significant global public health issue. Oxidative stress is a pivotal factor in the complex pathophysiology of pain, with glutathione peroxidase 4 (GPX4) recognized as a crucial antioxidant enzyme involved in both antioxidant defense mechanisms and ferroptosis pathways. This review systematically explores GPX4’s functions across various pain models, including neuropathic, inflammatory, low back, and cancer-related pain. Specifically, the focus includes GPX4’s physiological roles, antioxidant defense mechanisms, regulation of ferroptosis, involvement in signal transduction pathways, and metabolic regulation. By summarizing current research, we highlight the potential of GPX4-targeted therapies in pain management.https://doi.org/10.1007/s40122-024-00673-8Glutathione peroxidase 4Oxidative stressMechanismsPain regulation |
| spellingShingle | Shiwen Fan Kaixin Wang Tianhao Zhang Daling Deng Jiwei Shen Bowen Zhao Daan Fu Xiangdong Chen Mechanisms and Therapeutic Potential of GPX4 in Pain Modulation Pain and Therapy Glutathione peroxidase 4 Oxidative stress Mechanisms Pain regulation |
| title | Mechanisms and Therapeutic Potential of GPX4 in Pain Modulation |
| title_full | Mechanisms and Therapeutic Potential of GPX4 in Pain Modulation |
| title_fullStr | Mechanisms and Therapeutic Potential of GPX4 in Pain Modulation |
| title_full_unstemmed | Mechanisms and Therapeutic Potential of GPX4 in Pain Modulation |
| title_short | Mechanisms and Therapeutic Potential of GPX4 in Pain Modulation |
| title_sort | mechanisms and therapeutic potential of gpx4 in pain modulation |
| topic | Glutathione peroxidase 4 Oxidative stress Mechanisms Pain regulation |
| url | https://doi.org/10.1007/s40122-024-00673-8 |
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