Prediction of serum neuritin and neuron-specific enolase for prognosis in patients with traumatic brain injury combined with spinal cord injury
Background: Serum neuritin and neuron-specific enolase (NSE) have predictive value for the prognosis of patients with combined traumatic brain injury (TBI) and spinal cord injury (SCI). Studying their predictive effects has positive value for disease control and treatment. Methods: Sixty patients wi...
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Society of Medical Biochemists of Serbia, Belgrade
2024-01-01
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| Series: | Journal of Medical Biochemistry |
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| Online Access: | https://scindeks-clanci.ceon.rs/data/pdf/1452-8258/2024/1452-82582406870P.pdf |
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| author | Pu Bingbing Chen Yu Bi Qingguo Shen Jian Wang Lihui Han Ye |
| author_facet | Pu Bingbing Chen Yu Bi Qingguo Shen Jian Wang Lihui Han Ye |
| author_sort | Pu Bingbing |
| collection | DOAJ |
| description | Background: Serum neuritin and neuron-specific enolase (NSE) have predictive value for the prognosis of patients with combined traumatic brain injury (TBI) and spinal cord injury (SCI). Studying their predictive effects has positive value for disease control and treatment. Methods: Sixty patients with combined TBI and SCI were recruited and rolled into three groups according to prognosis: Group I (n=42, favourable prognosis), Group II (n=11, poor prognosis), and Group III (n=7, death). Clinical indicators were compared between the groups, and the predictive value of different indicators for prognosis was analyzed. Results: The proportion of patients with combined injuries to other organs and hypotension, as well as levels of platelets (PLT), D-dimer (D-D), antithrombin III (AT-III), S100 protein (S100 ), NSE, and serum neurofilament levels were significantly higher in Groups II and III compared to Group I. Conversely, the Glasgow Coma Scale (GCS) scores were significantly lower in Group I (P<0.05). Multivariable logistic regression analysis revealed that other organ injuries, GCS score, PLT, D-D, and AT-III significantly influenced the prognosis of TBI combined with SCI patients (P<0.05), while hypotension, NSE, serum neurofilament levels, S100 , and accompanying organ injuries were highly correlated with the prognosis of TBI combined with SCI patients (P<0.001). The predictive sensitivity, specificity, accuracy, positive predictive value, and negative predictive value of NSE combined with serum neurofilament in predicting the prognosis of TBI combined with SCI patients were significantly higher than the singular predictive efficacy of NSE or serum neurofilament alone (P<0.05). Conclusions: To evaluate the prognosis of TBI combined with SCI patients, consideration should be given to factors such as other organ injuries, hypotension, consciousness assessment, and levels of various biomarkers. Furthermore, combined testing of serum neurofilament and NSE can more accurately predict the prognosis of TBI combined with SCI patients. |
| format | Article |
| id | doaj-art-e5096df01d8e4e4cbcd8cc72d13a1d48 |
| institution | OA Journals |
| issn | 1452-8258 1452-8266 |
| language | English |
| publishDate | 2024-01-01 |
| publisher | Society of Medical Biochemists of Serbia, Belgrade |
| record_format | Article |
| series | Journal of Medical Biochemistry |
| spelling | doaj-art-e5096df01d8e4e4cbcd8cc72d13a1d482025-08-20T02:18:25ZengSociety of Medical Biochemists of Serbia, BelgradeJournal of Medical Biochemistry1452-82581452-82662024-01-0143687087810.5937/jomb0-454691452-82582406870PPrediction of serum neuritin and neuron-specific enolase for prognosis in patients with traumatic brain injury combined with spinal cord injuryPu Bingbing0Chen Yu1Bi Qingguo2Shen Jian3Wang Lihui4Han Ye5Pudong Hospital, Department of Rehabilitation, Shanghai, ChinaPudong Hospital, Department of Rehabilitation, Shanghai, ChinaZhoupu Hospital, Department of Critical Care, Shanghai, ChinaPudong Hospital, Department of Medical Equipment, Shanghai, ChinaPudong Hospital, Department of Rehabilitation, Shanghai, ChinaPeople's Hospital of Xuyi County, Department of Pathology, Huaian, Jiangsu Province, ChinaBackground: Serum neuritin and neuron-specific enolase (NSE) have predictive value for the prognosis of patients with combined traumatic brain injury (TBI) and spinal cord injury (SCI). Studying their predictive effects has positive value for disease control and treatment. Methods: Sixty patients with combined TBI and SCI were recruited and rolled into three groups according to prognosis: Group I (n=42, favourable prognosis), Group II (n=11, poor prognosis), and Group III (n=7, death). Clinical indicators were compared between the groups, and the predictive value of different indicators for prognosis was analyzed. Results: The proportion of patients with combined injuries to other organs and hypotension, as well as levels of platelets (PLT), D-dimer (D-D), antithrombin III (AT-III), S100 protein (S100 ), NSE, and serum neurofilament levels were significantly higher in Groups II and III compared to Group I. Conversely, the Glasgow Coma Scale (GCS) scores were significantly lower in Group I (P<0.05). Multivariable logistic regression analysis revealed that other organ injuries, GCS score, PLT, D-D, and AT-III significantly influenced the prognosis of TBI combined with SCI patients (P<0.05), while hypotension, NSE, serum neurofilament levels, S100 , and accompanying organ injuries were highly correlated with the prognosis of TBI combined with SCI patients (P<0.001). The predictive sensitivity, specificity, accuracy, positive predictive value, and negative predictive value of NSE combined with serum neurofilament in predicting the prognosis of TBI combined with SCI patients were significantly higher than the singular predictive efficacy of NSE or serum neurofilament alone (P<0.05). Conclusions: To evaluate the prognosis of TBI combined with SCI patients, consideration should be given to factors such as other organ injuries, hypotension, consciousness assessment, and levels of various biomarkers. Furthermore, combined testing of serum neurofilament and NSE can more accurately predict the prognosis of TBI combined with SCI patients.https://scindeks-clanci.ceon.rs/data/pdf/1452-8258/2024/1452-82582406870P.pdfserum neuritinneuron-specific enolasetraumatic brain injuryspinal cord injuryprognostic prediction |
| spellingShingle | Pu Bingbing Chen Yu Bi Qingguo Shen Jian Wang Lihui Han Ye Prediction of serum neuritin and neuron-specific enolase for prognosis in patients with traumatic brain injury combined with spinal cord injury Journal of Medical Biochemistry serum neuritin neuron-specific enolase traumatic brain injury spinal cord injury prognostic prediction |
| title | Prediction of serum neuritin and neuron-specific enolase for prognosis in patients with traumatic brain injury combined with spinal cord injury |
| title_full | Prediction of serum neuritin and neuron-specific enolase for prognosis in patients with traumatic brain injury combined with spinal cord injury |
| title_fullStr | Prediction of serum neuritin and neuron-specific enolase for prognosis in patients with traumatic brain injury combined with spinal cord injury |
| title_full_unstemmed | Prediction of serum neuritin and neuron-specific enolase for prognosis in patients with traumatic brain injury combined with spinal cord injury |
| title_short | Prediction of serum neuritin and neuron-specific enolase for prognosis in patients with traumatic brain injury combined with spinal cord injury |
| title_sort | prediction of serum neuritin and neuron specific enolase for prognosis in patients with traumatic brain injury combined with spinal cord injury |
| topic | serum neuritin neuron-specific enolase traumatic brain injury spinal cord injury prognostic prediction |
| url | https://scindeks-clanci.ceon.rs/data/pdf/1452-8258/2024/1452-82582406870P.pdf |
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