The association between structural connectivity and anti‐seizure medication response in patients with temporal lobe epilepsy
Abstract Objectives This study aimed to investigate the differences in structural connectivity and glymphatic system function between patients with temporal lobe epilepsy (TLE) and hippocampal sclerosis (HS) and healthy controls. Additionally, we analyzed the association between structural connectiv...
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| Format: | Article |
| Language: | English |
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Wiley
2024-12-01
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| Series: | Epilepsia Open |
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| Online Access: | https://doi.org/10.1002/epi4.13076 |
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| author | Dong Ah Lee Junghae Ko Sung‐Tae Kim Ho‐Joon Lee Kang Min Park |
| author_facet | Dong Ah Lee Junghae Ko Sung‐Tae Kim Ho‐Joon Lee Kang Min Park |
| author_sort | Dong Ah Lee |
| collection | DOAJ |
| description | Abstract Objectives This study aimed to investigate the differences in structural connectivity and glymphatic system function between patients with temporal lobe epilepsy (TLE) and hippocampal sclerosis (HS) and healthy controls. Additionally, we analyzed the association between structural connectivity, glymphatic system function, and antiseizure medication (ASM) response. Methods We retrospectively enrolled patients with TLE and HS and healthy controls who underwent diffusion tensor imaging at our hospital. We assessed structural connectivity in patients with TLE and HS and healthy controls by calculating network measures using graph theory and evaluated glymphatic system function using the diffusion tensor image analysis along the perivascular space (DTI‐ALPS) index. Patients with TLE and HS were categorized into two groups: ASM poor and good responders. Results We enrolled 55 patients with TLE and HS and 53 healthy controls. Of the 55 patients with TLE and HS, 39 were ASM poor responders, and 16 were ASM good responders. The assortativity coefficient in patients with TLE and HS was higher than that in healthy controls (0.004 vs. −0.007, p = 0.004), and the assortativity coefficient in ASM poor responders was lower than that in ASM good responders (−0.001 vs. −0.197, p = 0.003). The DTI‐ALPS index in patients with TLE and HS was lower than that in healthy controls (1.403 vs. 1.709, p < 0.001); however, the DTI‐ALPS index did not differ between ASM poor and good responders (1.411 vs. 1.385, p = 0.628). The DTI‐ALPS index had a significant negative correlation with age in patients with TLE and HS (r = −0.267, p = 0.049). Significance We confirmed increased assortativity coefficient in structural connectivity and decreased DTI‐ALPS index in patients with TLE and HS compared with healthy controls. Additionally, we demonstrated an association between decreased assortativity coefficient in structural connectivity and ASM poor response in patients with TLE patients and HS. Plain Language Summary This study investigates the relationship between brain connectivity changes and glymphatic system function with antiseizure medication response in patients with temporal lobe epilepsy and hippocampal sclerosis. The research reveals that these patients show altered brain connectivity and glymphatic function compared to healthy individuals. A key finding is the strong link between a specific connectivity measure (assortativity coefficient) and antiseizure medication response, providing valuable insights that could influence epilepsy treatment and future research directions. |
| format | Article |
| id | doaj-art-e500a865231f4e09b01c8b8675c37bce |
| institution | OA Journals |
| issn | 2470-9239 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Wiley |
| record_format | Article |
| series | Epilepsia Open |
| spelling | doaj-art-e500a865231f4e09b01c8b8675c37bce2025-08-20T02:33:46ZengWileyEpilepsia Open2470-92392024-12-01962408241810.1002/epi4.13076The association between structural connectivity and anti‐seizure medication response in patients with temporal lobe epilepsyDong Ah Lee0Junghae Ko1Sung‐Tae Kim2Ho‐Joon Lee3Kang Min Park4Department of Neurology, Haeundae Paik Hospital Inje University College of Medicine Busan Republic of KoreaDepartment of Internal Medicine, Haeundae Paik Hospital Inje University College of Medicine Busan Republic of KoreaDepartment of Neurosurgery, Haeundae Paik Hospital Inje University College of Medicine Busan Republic of KoreaDepartment of Radiology, Haeundae Paik Hospital Inje University College of Medicine Busan Republic of KoreaDepartment of Neurology, Haeundae Paik Hospital Inje University College of Medicine Busan Republic of KoreaAbstract Objectives This study aimed to investigate the differences in structural connectivity and glymphatic system function between patients with temporal lobe epilepsy (TLE) and hippocampal sclerosis (HS) and healthy controls. Additionally, we analyzed the association between structural connectivity, glymphatic system function, and antiseizure medication (ASM) response. Methods We retrospectively enrolled patients with TLE and HS and healthy controls who underwent diffusion tensor imaging at our hospital. We assessed structural connectivity in patients with TLE and HS and healthy controls by calculating network measures using graph theory and evaluated glymphatic system function using the diffusion tensor image analysis along the perivascular space (DTI‐ALPS) index. Patients with TLE and HS were categorized into two groups: ASM poor and good responders. Results We enrolled 55 patients with TLE and HS and 53 healthy controls. Of the 55 patients with TLE and HS, 39 were ASM poor responders, and 16 were ASM good responders. The assortativity coefficient in patients with TLE and HS was higher than that in healthy controls (0.004 vs. −0.007, p = 0.004), and the assortativity coefficient in ASM poor responders was lower than that in ASM good responders (−0.001 vs. −0.197, p = 0.003). The DTI‐ALPS index in patients with TLE and HS was lower than that in healthy controls (1.403 vs. 1.709, p < 0.001); however, the DTI‐ALPS index did not differ between ASM poor and good responders (1.411 vs. 1.385, p = 0.628). The DTI‐ALPS index had a significant negative correlation with age in patients with TLE and HS (r = −0.267, p = 0.049). Significance We confirmed increased assortativity coefficient in structural connectivity and decreased DTI‐ALPS index in patients with TLE and HS compared with healthy controls. Additionally, we demonstrated an association between decreased assortativity coefficient in structural connectivity and ASM poor response in patients with TLE patients and HS. Plain Language Summary This study investigates the relationship between brain connectivity changes and glymphatic system function with antiseizure medication response in patients with temporal lobe epilepsy and hippocampal sclerosis. The research reveals that these patients show altered brain connectivity and glymphatic function compared to healthy individuals. A key finding is the strong link between a specific connectivity measure (assortativity coefficient) and antiseizure medication response, providing valuable insights that could influence epilepsy treatment and future research directions.https://doi.org/10.1002/epi4.13076connectomediffusion tensor imaginghippocampal sclerosis |
| spellingShingle | Dong Ah Lee Junghae Ko Sung‐Tae Kim Ho‐Joon Lee Kang Min Park The association between structural connectivity and anti‐seizure medication response in patients with temporal lobe epilepsy Epilepsia Open connectome diffusion tensor imaging hippocampal sclerosis |
| title | The association between structural connectivity and anti‐seizure medication response in patients with temporal lobe epilepsy |
| title_full | The association between structural connectivity and anti‐seizure medication response in patients with temporal lobe epilepsy |
| title_fullStr | The association between structural connectivity and anti‐seizure medication response in patients with temporal lobe epilepsy |
| title_full_unstemmed | The association between structural connectivity and anti‐seizure medication response in patients with temporal lobe epilepsy |
| title_short | The association between structural connectivity and anti‐seizure medication response in patients with temporal lobe epilepsy |
| title_sort | association between structural connectivity and anti seizure medication response in patients with temporal lobe epilepsy |
| topic | connectome diffusion tensor imaging hippocampal sclerosis |
| url | https://doi.org/10.1002/epi4.13076 |
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