The Role of Macrophage Autophagy in Asthma: A Novel Therapeutic Strategy
Asthma is a chronic respiratory disease frequently associated with airway inflammation and remodeling. The development of asthma involves various inflammatory phenotypes that impact therapeutic effects, and macrophages are master innate immune cells in the airway that exert diverse functions includi...
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| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Wiley
2023-01-01
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| Series: | Mediators of Inflammation |
| Online Access: | http://dx.doi.org/10.1155/2023/7529685 |
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| _version_ | 1849435073781170176 |
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| author | Lijie Wang Xingxing Yuan Zhuying Li Fumin Zhi |
| author_facet | Lijie Wang Xingxing Yuan Zhuying Li Fumin Zhi |
| author_sort | Lijie Wang |
| collection | DOAJ |
| description | Asthma is a chronic respiratory disease frequently associated with airway inflammation and remodeling. The development of asthma involves various inflammatory phenotypes that impact therapeutic effects, and macrophages are master innate immune cells in the airway that exert diverse functions including phagocytosis, antigen presentation, and pathogen clearance, playing an important role in the pathogeneses of asthma. Recent studies have indicated that autophagy of macrophages affects polarization of phenotype and regulation of inflammation, which implies that regulating autophagy of macrophages may be a potential strategy for the treatment of asthma. Thus, this review summarizes the signaling pathways and effects of macrophage autophagy in asthma, which will provide a tactic for the development of novel targets for the treatment of this disease. |
| format | Article |
| id | doaj-art-e4fcd5ff88634ab49e9f88e327eede4e |
| institution | Kabale University |
| issn | 1466-1861 |
| language | English |
| publishDate | 2023-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Mediators of Inflammation |
| spelling | doaj-art-e4fcd5ff88634ab49e9f88e327eede4e2025-08-20T03:26:25ZengWileyMediators of Inflammation1466-18612023-01-01202310.1155/2023/7529685The Role of Macrophage Autophagy in Asthma: A Novel Therapeutic StrategyLijie Wang0Xingxing Yuan1Zhuying Li2Fumin Zhi3Department of Respiratory MedicineHeilongjiang University of Chinese MedicineDepartment of Respiratory MedicineDepartment of MedicalAsthma is a chronic respiratory disease frequently associated with airway inflammation and remodeling. The development of asthma involves various inflammatory phenotypes that impact therapeutic effects, and macrophages are master innate immune cells in the airway that exert diverse functions including phagocytosis, antigen presentation, and pathogen clearance, playing an important role in the pathogeneses of asthma. Recent studies have indicated that autophagy of macrophages affects polarization of phenotype and regulation of inflammation, which implies that regulating autophagy of macrophages may be a potential strategy for the treatment of asthma. Thus, this review summarizes the signaling pathways and effects of macrophage autophagy in asthma, which will provide a tactic for the development of novel targets for the treatment of this disease.http://dx.doi.org/10.1155/2023/7529685 |
| spellingShingle | Lijie Wang Xingxing Yuan Zhuying Li Fumin Zhi The Role of Macrophage Autophagy in Asthma: A Novel Therapeutic Strategy Mediators of Inflammation |
| title | The Role of Macrophage Autophagy in Asthma: A Novel Therapeutic Strategy |
| title_full | The Role of Macrophage Autophagy in Asthma: A Novel Therapeutic Strategy |
| title_fullStr | The Role of Macrophage Autophagy in Asthma: A Novel Therapeutic Strategy |
| title_full_unstemmed | The Role of Macrophage Autophagy in Asthma: A Novel Therapeutic Strategy |
| title_short | The Role of Macrophage Autophagy in Asthma: A Novel Therapeutic Strategy |
| title_sort | role of macrophage autophagy in asthma a novel therapeutic strategy |
| url | http://dx.doi.org/10.1155/2023/7529685 |
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