Brucella suis S2 strain inhibits IRE1/caspase-12/caspase-3 pathway-mediated apoptosis of microglia HMC3 by affecting the ubiquitination of CALR

Brucella suis S2 strain inhibits IRE1/caspase-12/caspase-3 pathway-mediated apoptosis of microglia HMC3 by affecting the ubiquitination of CALR

ABSTRACT Neurobrucellosis represents a severe complication of brucellosis, posing a considerable risk to human health and quality of life. This condition arises from an increased susceptibility to chronic Brucella infection, a significant clinical challenge. One key factor contributing to chronic ne...

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Bibliographic Details
Main Authors: Zhao Wang, Yanbai Wang, Shulong Yang, Zhenhai Wang, Qian Yang
Format: Article
Language:English
Published: American Society for Microbiology 2025-03-01
Series:mSphere
Subjects:
neurobrucellosis
Brucella suis S2
endoplasmic reticulum stress
microglia
apoptosis
IRE1/caspase-12/caspase-3 pathway
Online Access:https://journals.asm.org/doi/10.1128/msphere.00941-24
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