Association between persistent nocturnal sleep duration patterns and carotid intima-media thickness in Chinese patients with type 2 diabetes
Abstract The aim of this study was to investigate the association between persistent nocturnal sleep duration patterns and carotid intima-media thickness (CIMT) in Chinese patients with type 2 diabetes mellitus (T2DM). From March 1, 2018 to August 31, 2023, a cross-sectional study was carried out at...
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Nature Portfolio
2025-05-01
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| author | Xujia Ma Xingqiang Pan Miao Xu Li Li Jialin Li |
| author_facet | Xujia Ma Xingqiang Pan Miao Xu Li Li Jialin Li |
| author_sort | Xujia Ma |
| collection | DOAJ |
| description | Abstract The aim of this study was to investigate the association between persistent nocturnal sleep duration patterns and carotid intima-media thickness (CIMT) in Chinese patients with type 2 diabetes mellitus (T2DM). From March 1, 2018 to August 31, 2023, a cross-sectional study was carried out at the National Metabolic Management Center of the First Affiliated Hospital of Ningbo University. Each patient completed a minimum of three sleep questionnaire assessments during the study period. Group-based trajectory modeling was employed to identify distinct groups of patients exhibiting different trajectories of nocturnal sleep duration. CIMT ≥ 1 mm was used to assess early atherosclerotic changes in arterial structure. Multiple logistic regression was used to assess the association between trajectories of nocturnal sleep duration and CIMT. Three trajectories of nocturnal sleep duration were identified: persistent short (6.44 h: n = 114, 13.5% of all subjects), persistent moderate (7.59 h: n = 500, 59.0%), and persistent long (8.69 h: n = 233, 27.5%). After adjusting for age, sex, education, body mass index, physical activity, current smoking, current alcohol drinking, hypertension, hyperlipidemia, and HbA1c, the odds of CIMT ≥ 1 mm were found to be higher in patients with persistent short nocturnal sleep duration (OR 3.03, 95%CI 1.15, 7.98). However, no significant association was found between persistent long sleep duration at night and CIMT ≥ 1 mm. Persistent short nocturnal sleep duration was associated with increased CIMT in Chinese patients with T2DM. Further longitudinal studies are warranted to fully elucidate this topic. |
| format | Article |
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| institution | OA Journals |
| issn | 2045-2322 |
| language | English |
| publishDate | 2025-05-01 |
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| spelling | doaj-art-e4ebd20e498a4b47a184ffc87a5aa34f2025-08-20T01:51:30ZengNature PortfolioScientific Reports2045-23222025-05-011511910.1038/s41598-025-00785-xAssociation between persistent nocturnal sleep duration patterns and carotid intima-media thickness in Chinese patients with type 2 diabetesXujia Ma0Xingqiang Pan1Miao Xu2Li Li3Jialin Li4Department of Endocrinology and Metabolism, The First Affiliated Hospital of Ningbo UniversityNingbo Center for Disease Control and PreventionDepartment of Endocrinology and Metabolism, The First Affiliated Hospital of Ningbo UniversityDepartment of Endocrinology and Metabolism, The First Affiliated Hospital of Ningbo UniversityDepartment of Endocrinology and Metabolism, The First Affiliated Hospital of Ningbo UniversityAbstract The aim of this study was to investigate the association between persistent nocturnal sleep duration patterns and carotid intima-media thickness (CIMT) in Chinese patients with type 2 diabetes mellitus (T2DM). From March 1, 2018 to August 31, 2023, a cross-sectional study was carried out at the National Metabolic Management Center of the First Affiliated Hospital of Ningbo University. Each patient completed a minimum of three sleep questionnaire assessments during the study period. Group-based trajectory modeling was employed to identify distinct groups of patients exhibiting different trajectories of nocturnal sleep duration. CIMT ≥ 1 mm was used to assess early atherosclerotic changes in arterial structure. Multiple logistic regression was used to assess the association between trajectories of nocturnal sleep duration and CIMT. Three trajectories of nocturnal sleep duration were identified: persistent short (6.44 h: n = 114, 13.5% of all subjects), persistent moderate (7.59 h: n = 500, 59.0%), and persistent long (8.69 h: n = 233, 27.5%). After adjusting for age, sex, education, body mass index, physical activity, current smoking, current alcohol drinking, hypertension, hyperlipidemia, and HbA1c, the odds of CIMT ≥ 1 mm were found to be higher in patients with persistent short nocturnal sleep duration (OR 3.03, 95%CI 1.15, 7.98). However, no significant association was found between persistent long sleep duration at night and CIMT ≥ 1 mm. Persistent short nocturnal sleep duration was associated with increased CIMT in Chinese patients with T2DM. Further longitudinal studies are warranted to fully elucidate this topic.https://doi.org/10.1038/s41598-025-00785-xType 2 diabetesSleep durationTrajectoryCarotid intima-media thicknessChina |
| spellingShingle | Xujia Ma Xingqiang Pan Miao Xu Li Li Jialin Li Association between persistent nocturnal sleep duration patterns and carotid intima-media thickness in Chinese patients with type 2 diabetes Scientific Reports Type 2 diabetes Sleep duration Trajectory Carotid intima-media thickness China |
| title | Association between persistent nocturnal sleep duration patterns and carotid intima-media thickness in Chinese patients with type 2 diabetes |
| title_full | Association between persistent nocturnal sleep duration patterns and carotid intima-media thickness in Chinese patients with type 2 diabetes |
| title_fullStr | Association between persistent nocturnal sleep duration patterns and carotid intima-media thickness in Chinese patients with type 2 diabetes |
| title_full_unstemmed | Association between persistent nocturnal sleep duration patterns and carotid intima-media thickness in Chinese patients with type 2 diabetes |
| title_short | Association between persistent nocturnal sleep duration patterns and carotid intima-media thickness in Chinese patients with type 2 diabetes |
| title_sort | association between persistent nocturnal sleep duration patterns and carotid intima media thickness in chinese patients with type 2 diabetes |
| topic | Type 2 diabetes Sleep duration Trajectory Carotid intima-media thickness China |
| url | https://doi.org/10.1038/s41598-025-00785-x |
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