Fullerene nanoparticle as new therapeutic agent for the nervous system disorders
Neurodegenerative diseases and brain tumors are significant medical ailments that impact the brain. Administering therapeutic drugs to the brain is more challenging compared to other organs or systems. The existence of the blood-brain barrier (BBB) poses significant complexities and challenges in de...
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| Format: | Article |
| Language: | English |
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Mashhad University of Medical Sciences
2024-10-01
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| Series: | Nanomedicine Journal |
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| Online Access: | https://nmj.mums.ac.ir/article_24747_5dca515e86f3f45d26bc74936360971a.pdf |
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| author | Zhikal Omar Khudhur Abdullah H. Maad Hussein A. Ghanimi Arash Abdolmaleki |
| author_facet | Zhikal Omar Khudhur Abdullah H. Maad Hussein A. Ghanimi Arash Abdolmaleki |
| author_sort | Zhikal Omar Khudhur |
| collection | DOAJ |
| description | Neurodegenerative diseases and brain tumors are significant medical ailments that impact the brain. Administering therapeutic drugs to the brain is more challenging compared to other organs or systems. The existence of the blood-brain barrier (BBB) poses significant complexities and challenges in delivering drugs to the brain. This study explores the potential of Fullerene nanoparticles as a novel therapeutic agent for delivering drugs to the brain and their neuroprotective roles within the central nervous system. Novel drug delivery methods have been devised to surmount obstacles posed by BBB and accomplish targeted drug delivery to the brain. Carbon nanostructures are an excellent option for delivering drugs into the brain because they have favorable biocompatibility and can easily penetrate BBB. Furthermore, these nanocarriers has the potential to serve as a therapeutic agent inside the central nervous system, exhibiting neurogenerative properties in some cases. Additionally, their impact on the proliferation of neurons and their ability to counteract the formation of amyloid plaques is particularly remarkable. Carbon-based nanomaterials, including zero-dimensional fullerene (C60), one-dimensional carbon nanotubes (CNTs), and two-dimensional graphene, have shown significant potential in the area of nanomedicine. This is attributed to their unique blend of chemical and physical characteristics, as well as their hydrophobic surfaces. Fullerene nanoparticles have the potential to greatly improve the treatment of brain illnesses by serving as both carriers and therapeutic agents. |
| format | Article |
| id | doaj-art-e4ebc4f944fc4cfb9e4710bc23ed910d |
| institution | DOAJ |
| issn | 2322-3049 2322-5904 |
| language | English |
| publishDate | 2024-10-01 |
| publisher | Mashhad University of Medical Sciences |
| record_format | Article |
| series | Nanomedicine Journal |
| spelling | doaj-art-e4ebc4f944fc4cfb9e4710bc23ed910d2025-08-20T02:45:15ZengMashhad University of Medical SciencesNanomedicine Journal2322-30492322-59042024-10-0111434235910.22038/nmj.2024.78043.190324747Fullerene nanoparticle as new therapeutic agent for the nervous system disordersZhikal Omar Khudhur0Abdullah H. Maad1Hussein A. Ghanimi2Arash Abdolmaleki3Biology Education Department, Tishk International University, Erbil, IraqDepartment of pharmaceutics, College of pharmacy, University of Al-Ameed, Karbala, IraqCollege of Nursing, University of Al-Ameed, Karbala, IraqDepartment of Biophysics, Faculty of Advanced Technologies, University of Mohaghegh Ardabili, Namin, IranNeurodegenerative diseases and brain tumors are significant medical ailments that impact the brain. Administering therapeutic drugs to the brain is more challenging compared to other organs or systems. The existence of the blood-brain barrier (BBB) poses significant complexities and challenges in delivering drugs to the brain. This study explores the potential of Fullerene nanoparticles as a novel therapeutic agent for delivering drugs to the brain and their neuroprotective roles within the central nervous system. Novel drug delivery methods have been devised to surmount obstacles posed by BBB and accomplish targeted drug delivery to the brain. Carbon nanostructures are an excellent option for delivering drugs into the brain because they have favorable biocompatibility and can easily penetrate BBB. Furthermore, these nanocarriers has the potential to serve as a therapeutic agent inside the central nervous system, exhibiting neurogenerative properties in some cases. Additionally, their impact on the proliferation of neurons and their ability to counteract the formation of amyloid plaques is particularly remarkable. Carbon-based nanomaterials, including zero-dimensional fullerene (C60), one-dimensional carbon nanotubes (CNTs), and two-dimensional graphene, have shown significant potential in the area of nanomedicine. This is attributed to their unique blend of chemical and physical characteristics, as well as their hydrophobic surfaces. Fullerene nanoparticles have the potential to greatly improve the treatment of brain illnesses by serving as both carriers and therapeutic agents.https://nmj.mums.ac.ir/article_24747_5dca515e86f3f45d26bc74936360971a.pdffullerenesnanotechnologyneuroprotectionoxidative stress |
| spellingShingle | Zhikal Omar Khudhur Abdullah H. Maad Hussein A. Ghanimi Arash Abdolmaleki Fullerene nanoparticle as new therapeutic agent for the nervous system disorders Nanomedicine Journal fullerenes nanotechnology neuroprotection oxidative stress |
| title | Fullerene nanoparticle as new therapeutic agent for the nervous system disorders |
| title_full | Fullerene nanoparticle as new therapeutic agent for the nervous system disorders |
| title_fullStr | Fullerene nanoparticle as new therapeutic agent for the nervous system disorders |
| title_full_unstemmed | Fullerene nanoparticle as new therapeutic agent for the nervous system disorders |
| title_short | Fullerene nanoparticle as new therapeutic agent for the nervous system disorders |
| title_sort | fullerene nanoparticle as new therapeutic agent for the nervous system disorders |
| topic | fullerenes nanotechnology neuroprotection oxidative stress |
| url | https://nmj.mums.ac.ir/article_24747_5dca515e86f3f45d26bc74936360971a.pdf |
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