Disordered regions and folded modules in CAF-1 promote histone deposition in Schizosaccharomyces pombe

Disordered regions and folded modules in CAF-1 promote histone deposition in Schizosaccharomyces pombe

Genome and epigenome integrity in eukaryotes depends on the proper coupling of histone deposition with DNA synthesis. This process relies on the evolutionary conserved histone chaperone CAF-1 for which the links between structure and functions are still a puzzle. While studies of the Saccharomyces c...

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Main Authors: Fouad Ouasti, Maxime Audin, Karine Fréon, Jean-Pierre Quivy, Mehdi Tachekort, Elizabeth Cesard, Aurélien Thureau, Virginie Ropars, Paloma Fernández Varela, Gwenaelle Moal, Ibrahim Soumana Adamou, Aleksandra Uryga, Pierre Legrand, Jessica Andreani, Raphaël Guerois, Geneviève Almouzni, Sarah Lambert, Francoise Ochsenbein
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2024-02-01
Series:eLife
Subjects:
histone chaperone
Nucleosome assembly
epigenetic
genome integrity
nmr
saxs
Online Access:https://elifesciences.org/articles/91461
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