Correlation between 25-hydroxyvitamin D and severe headache or migraine: evidence from NHANES database
Objective: This study was formulated with the objective of elucidating the correlation between 25-hydroxyvitamin D (25(OH)D) and the occurrence of severe headache or migraine, employing a cross-sectional analytical approach. Methods: A cross-sectional survey was conducted over two cycles involving 7...
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Swedish Nutrition Foundation
2024-12-01
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| Series: | Food & Nutrition Research |
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| Online Access: | https://foodandnutritionresearch.net/index.php/fnr/article/view/10338/18459 |
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| author | Xiaolei Zhang Jiangwen Wu Ting Wu Liwen Guo Ruiping Zhang Xin Jin |
| author_facet | Xiaolei Zhang Jiangwen Wu Ting Wu Liwen Guo Ruiping Zhang Xin Jin |
| author_sort | Xiaolei Zhang |
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| description | Objective: This study was formulated with the objective of elucidating the correlation between 25-hydroxyvitamin D (25(OH)D) and the occurrence of severe headache or migraine, employing a cross-sectional analytical approach. Methods: A cross-sectional survey was conducted over two cycles involving 7,661 participants, utilizing data from the National Health and Nutrition Examination Survey (NHANES) conducted between 2001 and 2004. A weighted logistic regression method was employed to construct a relationship model between the two variables. Subgroup analysis, adjusting for confounding factors, was performed through stratified analysis to explore the association between 25(OH)D and severe headaches or migraines. Finally, a restricted cubic spline regression (RCS) was utilized to investigate the non-linear relationship between the variables. Results: A total of 7,661 participants were included in this study, with an overall prevalence of severe headaches or migraines of 1,576/7,661 (22.3%). The results from all models consistently indicated a significant negative correlation between serum 25(OH)D levels and the risk of severe headaches or migraines (P < 0.05). Stratified analysis revealed that in the female population (odds ratios [OR]: 0.995, 95% CI: 0.991–0.998, P = 0.001), never smokers (OR: 0.991, 95% CI: 0.985–0.997, P = 0.003), and non-drinkers (OR: 0.993, 95% CI: 0.987–0.999, P = 0.022), the risk of severe headaches or migraines decreased with increasing serum 25(OH)D concentrations. RCS results demonstrated a linear relationship between serum 25(OH)D levels and the risk of severe headaches or migraines. Conclusion: We discovered a negative correlation between serum 25(OH)D levels and the prevalence of severe headaches or migraines, particularly in females, non-smokers, and non-hypertensive individuals. Further clinical research is necessary to confirm these findings, establish causality, and explore potential preventive and therapeutic mechanisms for migraines. |
| format | Article |
| id | doaj-art-e4e8a0f4abd64a6c8926e232bb280def |
| institution | OA Journals |
| issn | 1654-661X |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Swedish Nutrition Foundation |
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| series | Food & Nutrition Research |
| spelling | doaj-art-e4e8a0f4abd64a6c8926e232bb280def2025-08-20T01:57:59ZengSwedish Nutrition FoundationFood & Nutrition Research1654-661X2024-12-016811110.29219/fnr.v68.1033810338Correlation between 25-hydroxyvitamin D and severe headache or migraine: evidence from NHANES databaseXiaolei Zhang0Jiangwen Wu1Ting Wu2Liwen Guo3Ruiping Zhang4Xin Jin5Pain Department, Xiangyang No. 1 People’s Hospital, Xiangyang City, ChinaPain Department, Xiangyang No. 1 People’s Hospital, Xiangyang City, ChinaPain Department, Xiangyang No. 1 People’s Hospital, Xiangyang City, ChinaPain Department, Xiangyang No. 1 People’s Hospital, Xiangyang City, ChinaPain Department, Xiangyang No. 1 People’s Hospital, Xiangyang City, ChinaPain Department, Xiangyang No. 1 People’s Hospital, Xiangyang City, ChinaObjective: This study was formulated with the objective of elucidating the correlation between 25-hydroxyvitamin D (25(OH)D) and the occurrence of severe headache or migraine, employing a cross-sectional analytical approach. Methods: A cross-sectional survey was conducted over two cycles involving 7,661 participants, utilizing data from the National Health and Nutrition Examination Survey (NHANES) conducted between 2001 and 2004. A weighted logistic regression method was employed to construct a relationship model between the two variables. Subgroup analysis, adjusting for confounding factors, was performed through stratified analysis to explore the association between 25(OH)D and severe headaches or migraines. Finally, a restricted cubic spline regression (RCS) was utilized to investigate the non-linear relationship between the variables. Results: A total of 7,661 participants were included in this study, with an overall prevalence of severe headaches or migraines of 1,576/7,661 (22.3%). The results from all models consistently indicated a significant negative correlation between serum 25(OH)D levels and the risk of severe headaches or migraines (P < 0.05). Stratified analysis revealed that in the female population (odds ratios [OR]: 0.995, 95% CI: 0.991–0.998, P = 0.001), never smokers (OR: 0.991, 95% CI: 0.985–0.997, P = 0.003), and non-drinkers (OR: 0.993, 95% CI: 0.987–0.999, P = 0.022), the risk of severe headaches or migraines decreased with increasing serum 25(OH)D concentrations. RCS results demonstrated a linear relationship between serum 25(OH)D levels and the risk of severe headaches or migraines. Conclusion: We discovered a negative correlation between serum 25(OH)D levels and the prevalence of severe headaches or migraines, particularly in females, non-smokers, and non-hypertensive individuals. Further clinical research is necessary to confirm these findings, establish causality, and explore potential preventive and therapeutic mechanisms for migraines.https://foodandnutritionresearch.net/index.php/fnr/article/view/10338/1845925-hydroxyvitamin dsevere headache or migraineassociationnhanes |
| spellingShingle | Xiaolei Zhang Jiangwen Wu Ting Wu Liwen Guo Ruiping Zhang Xin Jin Correlation between 25-hydroxyvitamin D and severe headache or migraine: evidence from NHANES database Food & Nutrition Research 25-hydroxyvitamin d severe headache or migraine association nhanes |
| title | Correlation between 25-hydroxyvitamin D and severe headache or migraine: evidence from NHANES database |
| title_full | Correlation between 25-hydroxyvitamin D and severe headache or migraine: evidence from NHANES database |
| title_fullStr | Correlation between 25-hydroxyvitamin D and severe headache or migraine: evidence from NHANES database |
| title_full_unstemmed | Correlation between 25-hydroxyvitamin D and severe headache or migraine: evidence from NHANES database |
| title_short | Correlation between 25-hydroxyvitamin D and severe headache or migraine: evidence from NHANES database |
| title_sort | correlation between 25 hydroxyvitamin d and severe headache or migraine evidence from nhanes database |
| topic | 25-hydroxyvitamin d severe headache or migraine association nhanes |
| url | https://foodandnutritionresearch.net/index.php/fnr/article/view/10338/18459 |
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