Outcome of surgical parathyroidectomy for tertiary hyperparathyroidism in kidney transplant recipients: tertiary hyperparathyroidism should not be ignored, for the sake of precious allografts
Tertiary hyperparathyroidism is a complication of kidney transplantation. This complicated condition carries over from the dialysis period and varies according to the function of the transplanted allograft. Treatments include pharmacotherapy (mainly using calcimimetics) and parathyroidectomy, but ca...
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2024-12-01
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| Series: | Renal Failure |
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| Online Access: | https://www.tandfonline.com/doi/10.1080/0886022X.2024.2333919 |
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| author | Michio Nakamura Shinya Takiguchi Saeko Uehara Yusuke Tomita |
| author_facet | Michio Nakamura Shinya Takiguchi Saeko Uehara Yusuke Tomita |
| author_sort | Michio Nakamura |
| collection | DOAJ |
| description | Tertiary hyperparathyroidism is a complication of kidney transplantation. This complicated condition carries over from the dialysis period and varies according to the function of the transplanted allograft. Treatments include pharmacotherapy (mainly using calcimimetics) and parathyroidectomy, but calcimimetics are currently not covered by the national insurance system in Japan. Two types of parathyroidectomy can be performed: subtotal parathyroidectomy; and total parathyroidectomy with partial autograft. Both types can be expected to improve hypercalcemia. Concerns about the postoperative deterioration of allograft function are influenced by preoperative allograft function, which is even more likely to be affected by early surgery after kidney transplantation. In general, transient deterioration of allograft function after surgery is not expected to affect graft survival rate in the medium to long term. Tertiary hyperparathyroidism in kidney transplant recipients negatively impacts allograft and patient survival rates, and parathyroidectomy can be expected to improve prognosis in both kidney recipients and dialysis patients. However, studies offering high levels of evidence remain lacking. |
| format | Article |
| id | doaj-art-e4e7395fe4224220b418551fbcaab2fd |
| institution | Kabale University |
| issn | 0886-022X 1525-6049 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Renal Failure |
| spelling | doaj-art-e4e7395fe4224220b418551fbcaab2fd2025-01-23T04:17:49ZengTaylor & Francis GroupRenal Failure0886-022X1525-60492024-12-0146110.1080/0886022X.2024.2333919Outcome of surgical parathyroidectomy for tertiary hyperparathyroidism in kidney transplant recipients: tertiary hyperparathyroidism should not be ignored, for the sake of precious allograftsMichio Nakamura0Shinya Takiguchi1Saeko Uehara2Yusuke Tomita3Department of Transplant Surgery, Tokai University School of Medicine, Isehara-City, Kanagawa, JapanDepartment of Transplant Surgery, Tokai University School of Medicine, Isehara-City, Kanagawa, JapanDepartment of Transplant Surgery, Tokai University School of Medicine, Isehara-City, Kanagawa, JapanDepartment of Transplant Surgery, Tokai University School of Medicine, Isehara-City, Kanagawa, JapanTertiary hyperparathyroidism is a complication of kidney transplantation. This complicated condition carries over from the dialysis period and varies according to the function of the transplanted allograft. Treatments include pharmacotherapy (mainly using calcimimetics) and parathyroidectomy, but calcimimetics are currently not covered by the national insurance system in Japan. Two types of parathyroidectomy can be performed: subtotal parathyroidectomy; and total parathyroidectomy with partial autograft. Both types can be expected to improve hypercalcemia. Concerns about the postoperative deterioration of allograft function are influenced by preoperative allograft function, which is even more likely to be affected by early surgery after kidney transplantation. In general, transient deterioration of allograft function after surgery is not expected to affect graft survival rate in the medium to long term. Tertiary hyperparathyroidism in kidney transplant recipients negatively impacts allograft and patient survival rates, and parathyroidectomy can be expected to improve prognosis in both kidney recipients and dialysis patients. However, studies offering high levels of evidence remain lacking.https://www.tandfonline.com/doi/10.1080/0886022X.2024.2333919Tertiary hyperparathyroidismkidney transplantationparathyroidectomycalcimimeticsallograft functionallograft survival |
| spellingShingle | Michio Nakamura Shinya Takiguchi Saeko Uehara Yusuke Tomita Outcome of surgical parathyroidectomy for tertiary hyperparathyroidism in kidney transplant recipients: tertiary hyperparathyroidism should not be ignored, for the sake of precious allografts Renal Failure Tertiary hyperparathyroidism kidney transplantation parathyroidectomy calcimimetics allograft function allograft survival |
| title | Outcome of surgical parathyroidectomy for tertiary hyperparathyroidism in kidney transplant recipients: tertiary hyperparathyroidism should not be ignored, for the sake of precious allografts |
| title_full | Outcome of surgical parathyroidectomy for tertiary hyperparathyroidism in kidney transplant recipients: tertiary hyperparathyroidism should not be ignored, for the sake of precious allografts |
| title_fullStr | Outcome of surgical parathyroidectomy for tertiary hyperparathyroidism in kidney transplant recipients: tertiary hyperparathyroidism should not be ignored, for the sake of precious allografts |
| title_full_unstemmed | Outcome of surgical parathyroidectomy for tertiary hyperparathyroidism in kidney transplant recipients: tertiary hyperparathyroidism should not be ignored, for the sake of precious allografts |
| title_short | Outcome of surgical parathyroidectomy for tertiary hyperparathyroidism in kidney transplant recipients: tertiary hyperparathyroidism should not be ignored, for the sake of precious allografts |
| title_sort | outcome of surgical parathyroidectomy for tertiary hyperparathyroidism in kidney transplant recipients tertiary hyperparathyroidism should not be ignored for the sake of precious allografts |
| topic | Tertiary hyperparathyroidism kidney transplantation parathyroidectomy calcimimetics allograft function allograft survival |
| url | https://www.tandfonline.com/doi/10.1080/0886022X.2024.2333919 |
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