The roles of serum vitamin D and tobacco smoke exposure in insomnia: a cross-sectional study of adults in the United States
AimTobacco smoke exposure and vitamin D (VD) status were both associated with insomnia. However, the combined effect of smoking and VD on insomnia has not been discussed. This study aimed to explore the role of VD in the association between tobacco smoke exposure and insomnia.MethodsData on adults w...
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Frontiers Media S.A.
2023-12-01
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| Series: | Frontiers in Nutrition |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fnut.2023.1285494/full |
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| author | Tianci Gao Tianci Gao Mengxing Hou Mengxing Hou Qianfei Wang Qianfei Wang Dong Liu Dong Liu Fenqiao Chen Yueyi Xing Jianqiang Mei Jianqiang Mei |
| author_facet | Tianci Gao Tianci Gao Mengxing Hou Mengxing Hou Qianfei Wang Qianfei Wang Dong Liu Dong Liu Fenqiao Chen Yueyi Xing Jianqiang Mei Jianqiang Mei |
| author_sort | Tianci Gao |
| collection | DOAJ |
| description | AimTobacco smoke exposure and vitamin D (VD) status were both associated with insomnia. However, the combined effect of smoking and VD on insomnia has not been discussed. This study aimed to explore the role of VD in the association between tobacco smoke exposure and insomnia.MethodsData on adults were extracted from the National Health and Nutrition Examination Surveys (NHANES) database in 2005–2008 for this cross-sectional study. Weighted univariate and multivariate logistic regression analyses were used to explore the associations between serum cotinine, serum VD, and insomnia. A surface diagram was drawn to reflect the effect of VD on the association between serum cotinine and insomnia. In addition, the potential regulating effect of VD in subgroups of smoking status was also performed. The evaluation index was odds ratios (ORs) with 95% confidence intervals (CIs).ResultsAmong the eligible participants, 1,766 had insomnia. After adjusting for covariates, we found that elevated serum cotinine levels were associated with higher odds of insomnia [OR = 1.55, 95% CI: (1.22, 1.97)]. However, the relationship between serum VD level and insomnia was not significant (P = 0.553). Higher serum cotinine levels were also associated with higher odds of insomnia [OR = 1.52, 95% CI: (1.17, 1.98)] when serum VD level was <75 nmol/L; however, this relationship became non-significant when serum VD concentration was elevated (P = 0.088). Additionally, the potential regulating effect of VD was also found in adults who were not smoking.ConclusionVD may play a potential regulative role in the association between tobacco smoke exposure and insomnia. Further studies are needed to clarify the causal relationships between VD, tobacco smoke exposure, and insomnia. |
| format | Article |
| id | doaj-art-e4e3bfa7c762453abd188ce9b8140968 |
| institution | OA Journals |
| issn | 2296-861X |
| language | English |
| publishDate | 2023-12-01 |
| publisher | Frontiers Media S.A. |
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| series | Frontiers in Nutrition |
| spelling | doaj-art-e4e3bfa7c762453abd188ce9b81409682025-08-20T02:03:04ZengFrontiers Media S.A.Frontiers in Nutrition2296-861X2023-12-011010.3389/fnut.2023.12854941285494The roles of serum vitamin D and tobacco smoke exposure in insomnia: a cross-sectional study of adults in the United StatesTianci Gao0Tianci Gao1Mengxing Hou2Mengxing Hou3Qianfei Wang4Qianfei Wang5Dong Liu6Dong Liu7Fenqiao Chen8Yueyi Xing9Jianqiang Mei10Jianqiang Mei11Graduate School, Hebei University of Chinese Medicine, Shijiazhuang, Hebei, ChinaDepartment of Emergency, First Affiliated Hospital, Hebei University of Chinese Medicine, Shijiazhuang, Hebei, ChinaGraduate School, Hebei University of Chinese Medicine, Shijiazhuang, Hebei, ChinaDepartment of Emergency, First Affiliated Hospital, Hebei University of Chinese Medicine, Shijiazhuang, Hebei, ChinaGraduate School, Hebei University of Chinese Medicine, Shijiazhuang, Hebei, ChinaDepartment of Emergency, First Affiliated Hospital, Hebei University of Chinese Medicine, Shijiazhuang, Hebei, ChinaGraduate School, Hebei University of Chinese Medicine, Shijiazhuang, Hebei, ChinaDepartment of Traditional Chinese Medicine, Hebei General Hospital, Shijiazhuang, Hebei, ChinaDepartment of Emergency, First Affiliated Hospital, Hebei University of Chinese Medicine, Shijiazhuang, Hebei, ChinaSchool of Basic Medicine, Hebei University of Chinese Medicine, Shijiazhuang, Hebei, ChinaGraduate School, Hebei University of Chinese Medicine, Shijiazhuang, Hebei, ChinaDepartment of Emergency, First Affiliated Hospital, Hebei University of Chinese Medicine, Shijiazhuang, Hebei, ChinaAimTobacco smoke exposure and vitamin D (VD) status were both associated with insomnia. However, the combined effect of smoking and VD on insomnia has not been discussed. This study aimed to explore the role of VD in the association between tobacco smoke exposure and insomnia.MethodsData on adults were extracted from the National Health and Nutrition Examination Surveys (NHANES) database in 2005–2008 for this cross-sectional study. Weighted univariate and multivariate logistic regression analyses were used to explore the associations between serum cotinine, serum VD, and insomnia. A surface diagram was drawn to reflect the effect of VD on the association between serum cotinine and insomnia. In addition, the potential regulating effect of VD in subgroups of smoking status was also performed. The evaluation index was odds ratios (ORs) with 95% confidence intervals (CIs).ResultsAmong the eligible participants, 1,766 had insomnia. After adjusting for covariates, we found that elevated serum cotinine levels were associated with higher odds of insomnia [OR = 1.55, 95% CI: (1.22, 1.97)]. However, the relationship between serum VD level and insomnia was not significant (P = 0.553). Higher serum cotinine levels were also associated with higher odds of insomnia [OR = 1.52, 95% CI: (1.17, 1.98)] when serum VD level was <75 nmol/L; however, this relationship became non-significant when serum VD concentration was elevated (P = 0.088). Additionally, the potential regulating effect of VD was also found in adults who were not smoking.ConclusionVD may play a potential regulative role in the association between tobacco smoke exposure and insomnia. Further studies are needed to clarify the causal relationships between VD, tobacco smoke exposure, and insomnia.https://www.frontiersin.org/articles/10.3389/fnut.2023.1285494/fullcotininevitamin Dinsomniaregulating effectNHANES |
| spellingShingle | Tianci Gao Tianci Gao Mengxing Hou Mengxing Hou Qianfei Wang Qianfei Wang Dong Liu Dong Liu Fenqiao Chen Yueyi Xing Jianqiang Mei Jianqiang Mei The roles of serum vitamin D and tobacco smoke exposure in insomnia: a cross-sectional study of adults in the United States Frontiers in Nutrition cotinine vitamin D insomnia regulating effect NHANES |
| title | The roles of serum vitamin D and tobacco smoke exposure in insomnia: a cross-sectional study of adults in the United States |
| title_full | The roles of serum vitamin D and tobacco smoke exposure in insomnia: a cross-sectional study of adults in the United States |
| title_fullStr | The roles of serum vitamin D and tobacco smoke exposure in insomnia: a cross-sectional study of adults in the United States |
| title_full_unstemmed | The roles of serum vitamin D and tobacco smoke exposure in insomnia: a cross-sectional study of adults in the United States |
| title_short | The roles of serum vitamin D and tobacco smoke exposure in insomnia: a cross-sectional study of adults in the United States |
| title_sort | roles of serum vitamin d and tobacco smoke exposure in insomnia a cross sectional study of adults in the united states |
| topic | cotinine vitamin D insomnia regulating effect NHANES |
| url | https://www.frontiersin.org/articles/10.3389/fnut.2023.1285494/full |
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