Candida Biofilms and the Host: Models and New Concepts for Eradication
Biofilms define mono- or multispecies communities embedded in a self-produced protective matrix, which is strongly attached to surfaces. They often are considered a general threat not only in industry but also in medicine. They constitute a permanent source of contamination, and they can disturb the...
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| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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Wiley
2012-01-01
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| Series: | International Journal of Microbiology |
| Online Access: | http://dx.doi.org/10.1155/2012/845352 |
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| _version_ | 1832560838894944256 |
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| author | Hélène Tournu Patrick Van Dijck |
| author_facet | Hélène Tournu Patrick Van Dijck |
| author_sort | Hélène Tournu |
| collection | DOAJ |
| description | Biofilms define mono- or multispecies communities embedded in a self-produced protective matrix, which is strongly attached to surfaces. They often are considered a general threat not only in industry but also in medicine. They constitute a permanent source of contamination, and they can disturb the proper usage of the material onto which they develop. This paper relates to some of the most recent approaches that have been elaborated to eradicate Candida biofilms, based on the vast effort put in ever-improving models of biofilm formation in vitro and in vivo, including novel flow systems, high-throughput techniques and mucosal models. Mixed biofilms, sustaining antagonist or beneficial cooperation between species, and their interplay with the host immune system are also prevalent topics. Alternative strategies against biofilms include the lock therapy and immunotherapy approaches, and material coating and improvements. The host-biofilm interactions are also discussed, together with their potential applications in Candida biofilm elimination. |
| format | Article |
| id | doaj-art-e4e0db6344e249f2b8f945ba00069dff |
| institution | Kabale University |
| issn | 1687-918X 1687-9198 |
| language | English |
| publishDate | 2012-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Microbiology |
| spelling | doaj-art-e4e0db6344e249f2b8f945ba00069dff2025-02-03T01:26:42ZengWileyInternational Journal of Microbiology1687-918X1687-91982012-01-01201210.1155/2012/845352845352Candida Biofilms and the Host: Models and New Concepts for EradicationHélène Tournu0Patrick Van Dijck1Laboratory of Molecular Cell Biology, Institute of Botany and Microbiology, Katholieke Universiteit Leuven, Flanders, 3001 Leuven-Heverlee, BelgiumLaboratory of Molecular Cell Biology, Institute of Botany and Microbiology, Katholieke Universiteit Leuven, Flanders, 3001 Leuven-Heverlee, BelgiumBiofilms define mono- or multispecies communities embedded in a self-produced protective matrix, which is strongly attached to surfaces. They often are considered a general threat not only in industry but also in medicine. They constitute a permanent source of contamination, and they can disturb the proper usage of the material onto which they develop. This paper relates to some of the most recent approaches that have been elaborated to eradicate Candida biofilms, based on the vast effort put in ever-improving models of biofilm formation in vitro and in vivo, including novel flow systems, high-throughput techniques and mucosal models. Mixed biofilms, sustaining antagonist or beneficial cooperation between species, and their interplay with the host immune system are also prevalent topics. Alternative strategies against biofilms include the lock therapy and immunotherapy approaches, and material coating and improvements. The host-biofilm interactions are also discussed, together with their potential applications in Candida biofilm elimination.http://dx.doi.org/10.1155/2012/845352 |
| spellingShingle | Hélène Tournu Patrick Van Dijck Candida Biofilms and the Host: Models and New Concepts for Eradication International Journal of Microbiology |
| title | Candida Biofilms and the Host: Models and New Concepts for Eradication |
| title_full | Candida Biofilms and the Host: Models and New Concepts for Eradication |
| title_fullStr | Candida Biofilms and the Host: Models and New Concepts for Eradication |
| title_full_unstemmed | Candida Biofilms and the Host: Models and New Concepts for Eradication |
| title_short | Candida Biofilms and the Host: Models and New Concepts for Eradication |
| title_sort | candida biofilms and the host models and new concepts for eradication |
| url | http://dx.doi.org/10.1155/2012/845352 |
| work_keys_str_mv | AT helenetournu candidabiofilmsandthehostmodelsandnewconceptsforeradication AT patrickvandijck candidabiofilmsandthehostmodelsandnewconceptsforeradication |