Phase 1 Study Evaluating the Pharmacokinetics, Dose Proportionality, Bioavailability, and Tolerability of Subcutaneous Levothyroxine Sodium (XP‐8121)

Phase 1 Study Evaluating the Pharmacokinetics, Dose Proportionality, Bioavailability, and Tolerability of Subcutaneous Levothyroxine Sodium (XP‐8121)

ABSTRACT Levothyroxine sodium has been the cornerstone of hypothyroidism management worldwide, with daily oral administration (PO) recognized as standard of care. Oral administration of levothyroxine, however, poses challenges due to variability in pharmacokinetics (PK), influenced by factors such a...

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Bibliographic Details
Main Authors: Richard Fitch, Diane R. Mould, Valentina Conoscenti, Robbie Huang, Dawn Harper
Format: Article
Language:English
Published: Wiley 2025-05-01
Series:Clinical and Translational Science
Subjects:
hypothyroidism
levothyroxine
once‐weekly
pharmacokinetics
subcutaneous
TSH
Online Access:https://doi.org/10.1111/cts.70244
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