Management Strategies for Xerostomia in Patients with Sjögren’s Syndrome: A Comprehensive Review
Xerostomia, commonly known as dry mouth, is a significant complication in patients with Sjögren’s syndrome (SS), an autoimmune disorder primarily affecting the salivary glands. This comprehensive review discusses the various management strategies available to alleviate xerostomia symptoms, including...
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2025-05-01
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| Series: | Journal of Pharmacy and Bioallied Sciences |
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| Online Access: | https://journals.lww.com/10.4103/jpbs.jpbs_1451_24 |
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| author | Dadi Swathi Jenny Lalmalsawmi Sailo Surabhi S. Ausare Debangana Bhattacharjee Shreya Buvariya Tundup Dolker Anuj Paul Maini |
| author_facet | Dadi Swathi Jenny Lalmalsawmi Sailo Surabhi S. Ausare Debangana Bhattacharjee Shreya Buvariya Tundup Dolker Anuj Paul Maini |
| author_sort | Dadi Swathi |
| collection | DOAJ |
| description | Xerostomia, commonly known as dry mouth, is a significant complication in patients with Sjögren’s syndrome (SS), an autoimmune disorder primarily affecting the salivary glands. This comprehensive review discusses the various management strategies available to alleviate xerostomia symptoms, including pharmacological and non-pharmacological approaches. Pharmacological treatments, such as cholinergic agents (pilocarpine and cevimeline), have shown effectiveness in stimulating salivary secretion, while topical therapies, like saliva substitutes, provide temporary relief. Non-pharmacological methods, including salivary gland stimulation through chewing gum and dietary modifications, offer additional symptom control. Emerging therapies, such as gene and stem cell therapy, hold promise for future treatment. A multimodal approach tailored to the individual needs of the patient is essential for the optimal management of xerostomia in SS, ultimately improving patients’ quality of life. The review highlights the importance of ongoing research into novel therapeutic approaches to enhance treatment outcomes. |
| format | Article |
| id | doaj-art-e4d63f1cee1948c3b7cc99b9d28e2097 |
| institution | OA Journals |
| issn | 0976-4879 0975-7406 |
| language | English |
| publishDate | 2025-05-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Journal of Pharmacy and Bioallied Sciences |
| spelling | doaj-art-e4d63f1cee1948c3b7cc99b9d28e20972025-08-20T02:03:24ZengWolters Kluwer Medknow PublicationsJournal of Pharmacy and Bioallied Sciences0976-48790975-74062025-05-0117Suppl 1S74S7610.4103/jpbs.jpbs_1451_24Management Strategies for Xerostomia in Patients with Sjögren’s Syndrome: A Comprehensive ReviewDadi SwathiJenny Lalmalsawmi SailoSurabhi S. AusareDebangana BhattacharjeeShreya BuvariyaTundup DolkerAnuj Paul MainiXerostomia, commonly known as dry mouth, is a significant complication in patients with Sjögren’s syndrome (SS), an autoimmune disorder primarily affecting the salivary glands. This comprehensive review discusses the various management strategies available to alleviate xerostomia symptoms, including pharmacological and non-pharmacological approaches. Pharmacological treatments, such as cholinergic agents (pilocarpine and cevimeline), have shown effectiveness in stimulating salivary secretion, while topical therapies, like saliva substitutes, provide temporary relief. Non-pharmacological methods, including salivary gland stimulation through chewing gum and dietary modifications, offer additional symptom control. Emerging therapies, such as gene and stem cell therapy, hold promise for future treatment. A multimodal approach tailored to the individual needs of the patient is essential for the optimal management of xerostomia in SS, ultimately improving patients’ quality of life. The review highlights the importance of ongoing research into novel therapeutic approaches to enhance treatment outcomes.https://journals.lww.com/10.4103/jpbs.jpbs_1451_24gene therapysaliva stimulantssaliva substitutessjögren’s syndromexerostomia |
| spellingShingle | Dadi Swathi Jenny Lalmalsawmi Sailo Surabhi S. Ausare Debangana Bhattacharjee Shreya Buvariya Tundup Dolker Anuj Paul Maini Management Strategies for Xerostomia in Patients with Sjögren’s Syndrome: A Comprehensive Review Journal of Pharmacy and Bioallied Sciences gene therapy saliva stimulants saliva substitutes sjögren’s syndrome xerostomia |
| title | Management Strategies for Xerostomia in Patients with Sjögren’s Syndrome: A Comprehensive Review |
| title_full | Management Strategies for Xerostomia in Patients with Sjögren’s Syndrome: A Comprehensive Review |
| title_fullStr | Management Strategies for Xerostomia in Patients with Sjögren’s Syndrome: A Comprehensive Review |
| title_full_unstemmed | Management Strategies for Xerostomia in Patients with Sjögren’s Syndrome: A Comprehensive Review |
| title_short | Management Strategies for Xerostomia in Patients with Sjögren’s Syndrome: A Comprehensive Review |
| title_sort | management strategies for xerostomia in patients with sjogren s syndrome a comprehensive review |
| topic | gene therapy saliva stimulants saliva substitutes sjögren’s syndrome xerostomia |
| url | https://journals.lww.com/10.4103/jpbs.jpbs_1451_24 |
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