Effects of Whole Body Therapeutic Hypothermia on Gastrointestinal Morbidity and Feeding Tolerance in Infants with Hypoxic Ischemic Encephalopathy
Objective. This retrospective cohort study evaluated the effects of whole body therapeutic hypothermia (WBTH) on gastrointestinal (GI) morbidity and feeding tolerance in infants with moderate-to-severe hypoxic ischemic encephalopathy (HIE). Study Design. Infants ≥ 35 weeks gestational age and ≥1800...
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| Format: | Article |
| Language: | English |
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Wiley
2014-01-01
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| Series: | International Journal of Pediatrics |
| Online Access: | http://dx.doi.org/10.1155/2014/643689 |
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| author | Kimberly M. Thornton Hongying Dai Seth Septer Joshua E. Petrikin |
| author_facet | Kimberly M. Thornton Hongying Dai Seth Septer Joshua E. Petrikin |
| author_sort | Kimberly M. Thornton |
| collection | DOAJ |
| description | Objective. This retrospective cohort study evaluated the effects of whole body therapeutic hypothermia (WBTH) on gastrointestinal (GI) morbidity and feeding tolerance in infants with moderate-to-severe hypoxic ischemic encephalopathy (HIE). Study Design. Infants ≥ 35 weeks gestational age and ≥1800 grams birth weight with moderate-to-severe HIE treated from 2000 to 2012 were compared. 68 patients had documented strictly defined criteria for WBTH: 32 historical control patients did not receive WBTH (non-WBTH) and 36 cohort patients received WBTH. Result. More of the non-WBTH group infants never initiated enteral feeds (28% versus 6%; P=0.02), never reached full enteral feeds (38% versus 6%, P=0.002), and never reached full oral feeds (56% versus 19%, P=0.002). Survival analyses demonstrated that the WBTH group reached full enteral feeds (median time: 11 versus 9 days; P=0.02) and full oral feeds (median time: 19 versus 10 days; P=0.01) sooner. The non-WBTH group had higher combined outcomes of death and gastric tube placement (47% versus 11%; P=0.001) and death and gavage feeds at discharge (44% versus 11%; P=0.005). Conclusion. WBTH may have beneficial effects on GI morbidity and feeding tolerance for infants with moderate-to-severe HIE. |
| format | Article |
| id | doaj-art-e4c76d2ce5584bc687cb0843a2a2ea65 |
| institution | OA Journals |
| issn | 1687-9740 1687-9759 |
| language | English |
| publishDate | 2014-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Pediatrics |
| spelling | doaj-art-e4c76d2ce5584bc687cb0843a2a2ea652025-08-20T02:21:18ZengWileyInternational Journal of Pediatrics1687-97401687-97592014-01-01201410.1155/2014/643689643689Effects of Whole Body Therapeutic Hypothermia on Gastrointestinal Morbidity and Feeding Tolerance in Infants with Hypoxic Ischemic EncephalopathyKimberly M. Thornton0Hongying Dai1Seth Septer2Joshua E. Petrikin3Department of Neonatology, Children’s Mercy Hospital, 2401 Gillham Road, Kansas City, MO 64108, USAResearch Development and Clinical Investigation, Children’s Mercy Hospital, 2401 Gillham Road, Kansas City, MO 64108, USASchool of Medicine, University of Missouri-Kansas City, 2401 Gillham Road, Kansas City, MO 64108, USADepartment of Neonatology, Children’s Mercy Hospital, 2401 Gillham Road, Kansas City, MO 64108, USAObjective. This retrospective cohort study evaluated the effects of whole body therapeutic hypothermia (WBTH) on gastrointestinal (GI) morbidity and feeding tolerance in infants with moderate-to-severe hypoxic ischemic encephalopathy (HIE). Study Design. Infants ≥ 35 weeks gestational age and ≥1800 grams birth weight with moderate-to-severe HIE treated from 2000 to 2012 were compared. 68 patients had documented strictly defined criteria for WBTH: 32 historical control patients did not receive WBTH (non-WBTH) and 36 cohort patients received WBTH. Result. More of the non-WBTH group infants never initiated enteral feeds (28% versus 6%; P=0.02), never reached full enteral feeds (38% versus 6%, P=0.002), and never reached full oral feeds (56% versus 19%, P=0.002). Survival analyses demonstrated that the WBTH group reached full enteral feeds (median time: 11 versus 9 days; P=0.02) and full oral feeds (median time: 19 versus 10 days; P=0.01) sooner. The non-WBTH group had higher combined outcomes of death and gastric tube placement (47% versus 11%; P=0.001) and death and gavage feeds at discharge (44% versus 11%; P=0.005). Conclusion. WBTH may have beneficial effects on GI morbidity and feeding tolerance for infants with moderate-to-severe HIE.http://dx.doi.org/10.1155/2014/643689 |
| spellingShingle | Kimberly M. Thornton Hongying Dai Seth Septer Joshua E. Petrikin Effects of Whole Body Therapeutic Hypothermia on Gastrointestinal Morbidity and Feeding Tolerance in Infants with Hypoxic Ischemic Encephalopathy International Journal of Pediatrics |
| title | Effects of Whole Body Therapeutic Hypothermia on Gastrointestinal Morbidity and Feeding Tolerance in Infants with Hypoxic Ischemic Encephalopathy |
| title_full | Effects of Whole Body Therapeutic Hypothermia on Gastrointestinal Morbidity and Feeding Tolerance in Infants with Hypoxic Ischemic Encephalopathy |
| title_fullStr | Effects of Whole Body Therapeutic Hypothermia on Gastrointestinal Morbidity and Feeding Tolerance in Infants with Hypoxic Ischemic Encephalopathy |
| title_full_unstemmed | Effects of Whole Body Therapeutic Hypothermia on Gastrointestinal Morbidity and Feeding Tolerance in Infants with Hypoxic Ischemic Encephalopathy |
| title_short | Effects of Whole Body Therapeutic Hypothermia on Gastrointestinal Morbidity and Feeding Tolerance in Infants with Hypoxic Ischemic Encephalopathy |
| title_sort | effects of whole body therapeutic hypothermia on gastrointestinal morbidity and feeding tolerance in infants with hypoxic ischemic encephalopathy |
| url | http://dx.doi.org/10.1155/2014/643689 |
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