Case Report of Probable DRESS Syndrome Associated with Ribociclib
Drug reaction with eosinophilia and systemic symptoms (DRESS) is a rare but known and potentially severe side effect of drugs. The recent development of cyclin-dependent kinase 4/6 (CDK4/6) inhibitors, such as ribociclib, has considerably improved the management of hormone receptor positive (HR+) an...
Saved in:
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2023-01-01
|
| Series: | Case Reports in Oncological Medicine |
| Online Access: | http://dx.doi.org/10.1155/2023/7904950 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832559591587577856 |
|---|---|
| author | Florian Carneiro Marine Bove Frédérique Beau-Salinas Tevy San Pierre Combe |
| author_facet | Florian Carneiro Marine Bove Frédérique Beau-Salinas Tevy San Pierre Combe |
| author_sort | Florian Carneiro |
| collection | DOAJ |
| description | Drug reaction with eosinophilia and systemic symptoms (DRESS) is a rare but known and potentially severe side effect of drugs. The recent development of cyclin-dependent kinase 4/6 (CDK4/6) inhibitors, such as ribociclib, has considerably improved the management of hormone receptor positive (HR+) and HER2 negative (HER2-) advanced breast cancer. Here, we present the case of an 83-year-old patient who developed a probable DRESS syndrome induced by ribociclib, presenting with fever, eosinophilia, rash, and hepatic cytolysis. The RegiSCAR score was 4. The symptomatology evolved favorably with topical and systemic corticosteroids, without any sequel. Another CDK4/6 inhibitor, palbociclib, was introduced later without any cross-toxicity and with an excellent therapeutic response for more than 3 years. |
| format | Article |
| id | doaj-art-e4c6db91382346558cf76a9d548a8f2f |
| institution | Kabale University |
| issn | 2090-6714 |
| language | English |
| publishDate | 2023-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Oncological Medicine |
| spelling | doaj-art-e4c6db91382346558cf76a9d548a8f2f2025-02-03T01:29:41ZengWileyCase Reports in Oncological Medicine2090-67142023-01-01202310.1155/2023/7904950Case Report of Probable DRESS Syndrome Associated with RibociclibFlorian Carneiro0Marine Bove1Frédérique Beau-Salinas2Tevy San3Pierre Combe4Department of Medical OncologyDepartment of Medical OncologyDepartment of PharmacosurveillanceCentre d’Oncologie et Radiothérapie 37 (CORT37)Centre d’Oncologie et Radiothérapie 37 (CORT37)Drug reaction with eosinophilia and systemic symptoms (DRESS) is a rare but known and potentially severe side effect of drugs. The recent development of cyclin-dependent kinase 4/6 (CDK4/6) inhibitors, such as ribociclib, has considerably improved the management of hormone receptor positive (HR+) and HER2 negative (HER2-) advanced breast cancer. Here, we present the case of an 83-year-old patient who developed a probable DRESS syndrome induced by ribociclib, presenting with fever, eosinophilia, rash, and hepatic cytolysis. The RegiSCAR score was 4. The symptomatology evolved favorably with topical and systemic corticosteroids, without any sequel. Another CDK4/6 inhibitor, palbociclib, was introduced later without any cross-toxicity and with an excellent therapeutic response for more than 3 years.http://dx.doi.org/10.1155/2023/7904950 |
| spellingShingle | Florian Carneiro Marine Bove Frédérique Beau-Salinas Tevy San Pierre Combe Case Report of Probable DRESS Syndrome Associated with Ribociclib Case Reports in Oncological Medicine |
| title | Case Report of Probable DRESS Syndrome Associated with Ribociclib |
| title_full | Case Report of Probable DRESS Syndrome Associated with Ribociclib |
| title_fullStr | Case Report of Probable DRESS Syndrome Associated with Ribociclib |
| title_full_unstemmed | Case Report of Probable DRESS Syndrome Associated with Ribociclib |
| title_short | Case Report of Probable DRESS Syndrome Associated with Ribociclib |
| title_sort | case report of probable dress syndrome associated with ribociclib |
| url | http://dx.doi.org/10.1155/2023/7904950 |
| work_keys_str_mv | AT floriancarneiro casereportofprobabledresssyndromeassociatedwithribociclib AT marinebove casereportofprobabledresssyndromeassociatedwithribociclib AT frederiquebeausalinas casereportofprobabledresssyndromeassociatedwithribociclib AT tevysan casereportofprobabledresssyndromeassociatedwithribociclib AT pierrecombe casereportofprobabledresssyndromeassociatedwithribociclib |