Magnolol and its semi-synthetic derivatives: a comprehensive review of anti-cancer mechanisms, pharmacokinetics, and future therapeutic potential

Magnolol and its semi-synthetic derivatives: a comprehensive review of anti-cancer mechanisms, pharmacokinetics, and future therapeutic potential

Abstract In recent years, magnolol (MG), a natural active compound of polyphenolic nature, has garnered significant interest for its anti-cancer effects. Numerous studies conducted on cell lines and animal models have indicated a positive impact of administering drugs or semi-synthesized products de...

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Bibliographic Details
Main Authors: Asmita Rayamajhi, Nisha Gyawali, Deepa Karki, Luis E. Pérez-Caltzontzin, Sheila I. Peña-Corona, Hernán Cortés, Achyut Adhikari, Gerardo Leyva-Gómez, Yadav Uprety, Solomon Habtemariam, Lashyn Kiyekbayeva, Javad Sharifi-Rad
Format: Article
Language:English
Published: Springer 2025-05-01
Series:Discover Oncology
Subjects:
Natural polyphenolic compound
Magnolol
Cancer cell growth inhibition
Low water solubility
Magnolia species
Semi-synthetic derivatives
Online Access:https://doi.org/10.1007/s12672-025-02409-2
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