The Antimicrobial Resistance of <i>Candida</i>: A 5-Year Retrospective Analysis at a Tertiary Hospital in Jordan
<i>Candida</i> infections are a global health concern, increasingly complicated by rising antimicrobial resistance (AMR). This study analyzed the prevalence and AMR patterns of circulating <i>Candida</i> species in Amman, Jordan, using electronic records from a tertiary teach...
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2025-01-01
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| author | Anas H. Abu-Humaidan Areen Alshdaifat Dima Awajan Mohammad Abu-Hmidan Abeer Alshdifat Hanan Hasan Fatima M. Ahmad Nader Alaridah Amal Irshaid Dina Yamin |
| author_facet | Anas H. Abu-Humaidan Areen Alshdaifat Dima Awajan Mohammad Abu-Hmidan Abeer Alshdifat Hanan Hasan Fatima M. Ahmad Nader Alaridah Amal Irshaid Dina Yamin |
| author_sort | Anas H. Abu-Humaidan |
| collection | DOAJ |
| description | <i>Candida</i> infections are a global health concern, increasingly complicated by rising antimicrobial resistance (AMR). This study analyzed the prevalence and AMR patterns of circulating <i>Candida</i> species in Amman, Jordan, using electronic records from a tertiary teaching hospital’s microbiology lab (from 2017 to 2022). Complete records of <i>Candida</i> isolates (n = 2673) were assessed by sample type, species, and AMR. Among positive blood samples, <i>C. albicans</i> accounted for the majority (38.7%), followed by <i>C. tropicalis</i> (19.0%), <i>C. parapsilosis</i> (18.3%), <i>Nakaseomyces glabratus</i> (14.6%), and <i>Pichia kudriavzevii</i> (9.5%). Non-<i>albicans</i> species demonstrated higher resistance to Caspofungin, notably <i>P. kudriavzevii</i> (23.1%), <i>N. glabratus</i> (30.0%), and <i>C. parapsilosis</i> (32.0%), compared to <i>C. albicans</i> (1.9%). In high vaginal swabs, <i>C. albicans</i> was most prevalent (63.7%), with <i>N. glabratus</i> also notable (28.6%); Fluconazole resistance in <i>C. albicans</i> remained low (2.0%). Across all pooled isolates, AMR was similar between inpatients and outpatients, except for Micafungin, where inpatient resistance was significantly higher. In conclusion, non-<i>albicans</i> species predominated in blood infections and demonstrated pronounced AMR. Micafungin resistance was notably higher among inpatients. Variations in <i>Candida</i> species and AMR by sample type suggest that aggregating samples in registry studies may obscure critical patterns. |
| format | Article |
| id | doaj-art-e4bb53e033ff4a0da5a4674754cd2dae |
| institution | DOAJ |
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| language | English |
| publishDate | 2025-01-01 |
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| spelling | doaj-art-e4bb53e033ff4a0da5a4674754cd2dae2025-08-20T03:12:02ZengMDPI AGJournal of Fungi2309-608X2025-01-011128710.3390/jof11020087The Antimicrobial Resistance of <i>Candida</i>: A 5-Year Retrospective Analysis at a Tertiary Hospital in JordanAnas H. Abu-Humaidan0Areen Alshdaifat1Dima Awajan2Mohammad Abu-Hmidan3Abeer Alshdifat4Hanan Hasan5Fatima M. Ahmad6Nader Alaridah7Amal Irshaid8Dina Yamin9Department of Pathology, Microbiology and Forensic Medicine, School of Medicine, The University of Jordan, Amman 11942, JordanDepartment of Pathology, Microbiology and Forensic Medicine, School of Medicine, The University of Jordan, Amman 11942, JordanDepartment of Clinical Pharmacy and Therapeutics, Applied Science Private University, Amman 11931, JordanDepartment of Pathology, Microbiology and Forensic Medicine, School of Medicine, The University of Jordan, Amman 11942, JordanFaculty of Medicine, Yarmouk University, Irbid 21163, JordanDepartment of Medical Laboratory Sciences, School of Science, The University of Jordan, Amman 11942, JordanDepartment of Pathology, Microbiology and Forensic Medicine, School of Medicine, The University of Jordan, Amman 11942, JordanDepartment of Pathology, Microbiology and Forensic Medicine, School of Medicine, The University of Jordan, Amman 11942, JordanDepartment of Pathology, Microbiology and Forensic Medicine, School of Medicine, The University of Jordan, Amman 11942, JordanDepartment of Medical Laboratory Sciences, School of Science, The University of Jordan, Amman 11942, Jordan<i>Candida</i> infections are a global health concern, increasingly complicated by rising antimicrobial resistance (AMR). This study analyzed the prevalence and AMR patterns of circulating <i>Candida</i> species in Amman, Jordan, using electronic records from a tertiary teaching hospital’s microbiology lab (from 2017 to 2022). Complete records of <i>Candida</i> isolates (n = 2673) were assessed by sample type, species, and AMR. Among positive blood samples, <i>C. albicans</i> accounted for the majority (38.7%), followed by <i>C. tropicalis</i> (19.0%), <i>C. parapsilosis</i> (18.3%), <i>Nakaseomyces glabratus</i> (14.6%), and <i>Pichia kudriavzevii</i> (9.5%). Non-<i>albicans</i> species demonstrated higher resistance to Caspofungin, notably <i>P. kudriavzevii</i> (23.1%), <i>N. glabratus</i> (30.0%), and <i>C. parapsilosis</i> (32.0%), compared to <i>C. albicans</i> (1.9%). In high vaginal swabs, <i>C. albicans</i> was most prevalent (63.7%), with <i>N. glabratus</i> also notable (28.6%); Fluconazole resistance in <i>C. albicans</i> remained low (2.0%). Across all pooled isolates, AMR was similar between inpatients and outpatients, except for Micafungin, where inpatient resistance was significantly higher. In conclusion, non-<i>albicans</i> species predominated in blood infections and demonstrated pronounced AMR. Micafungin resistance was notably higher among inpatients. Variations in <i>Candida</i> species and AMR by sample type suggest that aggregating samples in registry studies may obscure critical patterns.https://www.mdpi.com/2309-608X/11/2/87<i>Candida</i><i>albicans</i><i>tropicalis</i><i>Nakaseomyces glabratus</i><i>Pichia kudriavzevii</i>registry |
| spellingShingle | Anas H. Abu-Humaidan Areen Alshdaifat Dima Awajan Mohammad Abu-Hmidan Abeer Alshdifat Hanan Hasan Fatima M. Ahmad Nader Alaridah Amal Irshaid Dina Yamin The Antimicrobial Resistance of <i>Candida</i>: A 5-Year Retrospective Analysis at a Tertiary Hospital in Jordan Journal of Fungi <i>Candida</i> <i>albicans</i> <i>tropicalis</i> <i>Nakaseomyces glabratus</i> <i>Pichia kudriavzevii</i> registry |
| title | The Antimicrobial Resistance of <i>Candida</i>: A 5-Year Retrospective Analysis at a Tertiary Hospital in Jordan |
| title_full | The Antimicrobial Resistance of <i>Candida</i>: A 5-Year Retrospective Analysis at a Tertiary Hospital in Jordan |
| title_fullStr | The Antimicrobial Resistance of <i>Candida</i>: A 5-Year Retrospective Analysis at a Tertiary Hospital in Jordan |
| title_full_unstemmed | The Antimicrobial Resistance of <i>Candida</i>: A 5-Year Retrospective Analysis at a Tertiary Hospital in Jordan |
| title_short | The Antimicrobial Resistance of <i>Candida</i>: A 5-Year Retrospective Analysis at a Tertiary Hospital in Jordan |
| title_sort | antimicrobial resistance of i candida i a 5 year retrospective analysis at a tertiary hospital in jordan |
| topic | <i>Candida</i> <i>albicans</i> <i>tropicalis</i> <i>Nakaseomyces glabratus</i> <i>Pichia kudriavzevii</i> registry |
| url | https://www.mdpi.com/2309-608X/11/2/87 |
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