Lycorine protects motor neurons against TDP-43 proteinopathy-induced degeneration in cross-species models with amyotrophic lateral sclerosis

Lycorine protects motor neurons against TDP-43 proteinopathy-induced degeneration in cross-species models with amyotrophic lateral sclerosis

Aggregation of TAR-DNA binding protein-43 (TDP-43) is a pathological feature present in nearly 97 % cases of amyotrophic lateral sclerosis (ALS), making it an attractive target for pathogenic studies and drug screening. Here, we have performed a high-throughput screening of 1500 compounds from a nat...

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Bibliographic Details
Main Authors: Jing Wen, Yunhao Li, Yanzhu Qin, Lingli Yan, Ke Zhang, Ang Li, Ziying Wang, Feng Yu, Jianheng Lai, Wei Yang, Yong U. Liu, Dajiang Qin, Huanxing Su
Format: Article
Language:English
Published: Elsevier 2024-12-01
Series:Pharmacological Research
Subjects:
ALS
TDP-43 proteinopathy
Lycorine
UPS
Motor neurons
Online Access:http://www.sciencedirect.com/science/article/pii/S1043661824004638
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