Treatment of an endodontic-periodontal lesion using peripheral blood mesenchymal stem cells (PBMSCs) and platelet-rich fibrin matrix (PRFM): A case report
In the current report, we discuss the available treatment options and present a successfully treated periodontal-endodontic lesion using autogenous peripheral blood mesenchymal stem cells (PBMSCs) and platelet-rich fibrin matrix (PRFM). A patient presented with a complaint of food impaction and bad...
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| Format: | Article |
| Language: | English |
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Tabriz University of Medical Sciences
2025-03-01
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| Series: | Journal of Advanced Periodontology and Implant Dentistry |
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| Online Access: | https://japid.tbzmed.ac.ir/PDF/japid-17-54.pdf |
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| author | Sphoorthi Anup Belludi Sharaz Shaik Neha Pradhan Sreeparvathy Rema |
| author_facet | Sphoorthi Anup Belludi Sharaz Shaik Neha Pradhan Sreeparvathy Rema |
| author_sort | Sphoorthi Anup Belludi |
| collection | DOAJ |
| description | In the current report, we discuss the available treatment options and present a successfully treated periodontal-endodontic lesion using autogenous peripheral blood mesenchymal stem cells (PBMSCs) and platelet-rich fibrin matrix (PRFM). A patient presented with a complaint of food impaction and bad breath. Clinically, the lower right first molar was non-vital and had a deep periodontal pocket and attachment loss. Radiographically, the distal root had an angular bone loss extending to the apex. The endodontic condition was treated with chemomechanical debridement, calcium hydroxide dressing, and obturation. Later, we reflected a full-thickness mucoperiosteal flap and thoroughly debrided the granulation tissue. We filled the defect with a gel containing PBMSCs and PRFM, prepared from the patient’s peripheral blood, and sutured the flap. After nine months, we noticed significant osseous fill and 5 mm of gain in the clinical attachment level. The outcomes of the case show the periodontal regenerative potential of the novel combination. |
| format | Article |
| id | doaj-art-e4b9ff9c33e044398bf13dbc4e24182f |
| institution | DOAJ |
| issn | 2645-5390 |
| language | English |
| publishDate | 2025-03-01 |
| publisher | Tabriz University of Medical Sciences |
| record_format | Article |
| series | Journal of Advanced Periodontology and Implant Dentistry |
| spelling | doaj-art-e4b9ff9c33e044398bf13dbc4e24182f2025-08-20T03:10:17ZengTabriz University of Medical SciencesJournal of Advanced Periodontology and Implant Dentistry2645-53902025-03-01171545810.34172/japid.025.3502japid-3502Treatment of an endodontic-periodontal lesion using peripheral blood mesenchymal stem cells (PBMSCs) and platelet-rich fibrin matrix (PRFM): A case reportSphoorthi Anup Belludi0Sharaz Shaik1Neha Pradhan2Sreeparvathy Rema3Department of Periodontics, K.L.E Society’s Institute of Dental Sciences, Bengaluru, Karnataka, IndiaLincoln University PhD Program, Lenora Institute of Dental Science, Rajahmundry, Andhra Pradesh, IndiaDepartment of Periodontics, K.L.E Society’s Institute of Dental Sciences, Bengaluru, Karnataka, IndiaDepartment of Periodontics, K.L.E Society’s Institute of Dental Sciences, Bengaluru, Karnataka, IndiaIn the current report, we discuss the available treatment options and present a successfully treated periodontal-endodontic lesion using autogenous peripheral blood mesenchymal stem cells (PBMSCs) and platelet-rich fibrin matrix (PRFM). A patient presented with a complaint of food impaction and bad breath. Clinically, the lower right first molar was non-vital and had a deep periodontal pocket and attachment loss. Radiographically, the distal root had an angular bone loss extending to the apex. The endodontic condition was treated with chemomechanical debridement, calcium hydroxide dressing, and obturation. Later, we reflected a full-thickness mucoperiosteal flap and thoroughly debrided the granulation tissue. We filled the defect with a gel containing PBMSCs and PRFM, prepared from the patient’s peripheral blood, and sutured the flap. After nine months, we noticed significant osseous fill and 5 mm of gain in the clinical attachment level. The outcomes of the case show the periodontal regenerative potential of the novel combination.https://japid.tbzmed.ac.ir/PDF/japid-17-54.pdfendo-periodontal lesionperipheral blood stem cellsplatelet-rich fibrinregenerative endodontics |
| spellingShingle | Sphoorthi Anup Belludi Sharaz Shaik Neha Pradhan Sreeparvathy Rema Treatment of an endodontic-periodontal lesion using peripheral blood mesenchymal stem cells (PBMSCs) and platelet-rich fibrin matrix (PRFM): A case report Journal of Advanced Periodontology and Implant Dentistry endo-periodontal lesion peripheral blood stem cells platelet-rich fibrin regenerative endodontics |
| title | Treatment of an endodontic-periodontal lesion using peripheral blood mesenchymal stem cells (PBMSCs) and platelet-rich fibrin matrix (PRFM): A case report |
| title_full | Treatment of an endodontic-periodontal lesion using peripheral blood mesenchymal stem cells (PBMSCs) and platelet-rich fibrin matrix (PRFM): A case report |
| title_fullStr | Treatment of an endodontic-periodontal lesion using peripheral blood mesenchymal stem cells (PBMSCs) and platelet-rich fibrin matrix (PRFM): A case report |
| title_full_unstemmed | Treatment of an endodontic-periodontal lesion using peripheral blood mesenchymal stem cells (PBMSCs) and platelet-rich fibrin matrix (PRFM): A case report |
| title_short | Treatment of an endodontic-periodontal lesion using peripheral blood mesenchymal stem cells (PBMSCs) and platelet-rich fibrin matrix (PRFM): A case report |
| title_sort | treatment of an endodontic periodontal lesion using peripheral blood mesenchymal stem cells pbmscs and platelet rich fibrin matrix prfm a case report |
| topic | endo-periodontal lesion peripheral blood stem cells platelet-rich fibrin regenerative endodontics |
| url | https://japid.tbzmed.ac.ir/PDF/japid-17-54.pdf |
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