Association of Irisin with Fat Mass, Resting Energy Expenditure, and Daily Activity in Conditions of Extreme Body Mass Index
FNDC5/irisin has been recently postulated as beneficial in the treatment of obesity and diabetes because it is induced in muscle by exercise, increasing energy expenditure. However, recent reports have shown that WAT also secretes irisin and that circulating irisin is elevated in obese subjects. The...
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| Format: | Article |
| Language: | English |
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Wiley
2014-01-01
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| Series: | International Journal of Endocrinology |
| Online Access: | http://dx.doi.org/10.1155/2014/857270 |
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| author | María Pardo Ana B. Crujeiras María Amil Zaida Aguera Susana Jiménez-Murcia Rosa Baños Cristina Botella Rafael de la Torre Xavier Estivill Ana B. Fagundo Jose M. Fernández-Real José C. Fernández-García Gema Fruhbeck Javier Gómez-Ambrosi Roser Rodríguez Francisco J. Tinahones Fernando Fernández-Aranda Felipe F. Casanueva |
| author_facet | María Pardo Ana B. Crujeiras María Amil Zaida Aguera Susana Jiménez-Murcia Rosa Baños Cristina Botella Rafael de la Torre Xavier Estivill Ana B. Fagundo Jose M. Fernández-Real José C. Fernández-García Gema Fruhbeck Javier Gómez-Ambrosi Roser Rodríguez Francisco J. Tinahones Fernando Fernández-Aranda Felipe F. Casanueva |
| author_sort | María Pardo |
| collection | DOAJ |
| description | FNDC5/irisin has been recently postulated as beneficial in the treatment of obesity and diabetes because it is induced in muscle by exercise, increasing energy expenditure. However, recent reports have shown that WAT also secretes irisin and that circulating irisin is elevated in obese subjects. The aim of this study was to evaluate irisin levels in conditions of extreme BMI and its correlation with basal metabolism and daily activity. The study involved 145 female patients, including 96 with extreme BMIs (30 anorexic (AN) and 66 obese (OB)) and 49 healthy normal weight (NW). The plasma irisin levels were significantly elevated in the OB patients compared with the AN and NW patients. Irisin also correlated positively with body weight, BMI, and fat mass. The OB patients exhibited the highest REE and higher daily physical activity compared with the AN patients but lower activity compared with the NW patients. The irisin levels were inversely correlated with daily physical activity and directly correlated with REE. Fat mass contributed to most of the variability of the irisin plasma levels independently of the other studied parameters. Conclusion. Irisin levels are influenced by energy expenditure independently of daily physical activity but fat mass is the main contributing factor. |
| format | Article |
| id | doaj-art-e4b4318205dc47568c4ef8933bf97ce4 |
| institution | Kabale University |
| issn | 1687-8337 1687-8345 |
| language | English |
| publishDate | 2014-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Endocrinology |
| spelling | doaj-art-e4b4318205dc47568c4ef8933bf97ce42025-02-03T05:44:56ZengWileyInternational Journal of Endocrinology1687-83371687-83452014-01-01201410.1155/2014/857270857270Association of Irisin with Fat Mass, Resting Energy Expenditure, and Daily Activity in Conditions of Extreme Body Mass IndexMaría Pardo0Ana B. Crujeiras1María Amil2Zaida Aguera3Susana Jiménez-Murcia4Rosa Baños5Cristina Botella6Rafael de la Torre7Xavier Estivill8Ana B. Fagundo9Jose M. Fernández-Real10José C. Fernández-García11Gema Fruhbeck12Javier Gómez-Ambrosi13Roser Rodríguez14Francisco J. Tinahones15Fernando Fernández-Aranda16Felipe F. Casanueva17Laboratory of Molecular and Cellular Endocrinology, Health Research Institute of Santiago (IDIS), University Hospital of Santiago (XXIS/SERGAS) and Santiago de Compostela University (USC), 15706 Santiago de Compostela, SpainLaboratory of Molecular and Cellular Endocrinology, Health Research Institute of Santiago (IDIS), University Hospital of Santiago (XXIS/SERGAS) and Santiago de Compostela University (USC), 15706 Santiago de Compostela, SpainLaboratory of Molecular and Cellular Endocrinology, Health Research Institute of Santiago (IDIS), University Hospital of Santiago (XXIS/SERGAS) and Santiago de Compostela University (USC), 15706 Santiago de Compostela, SpainCIBER Fisiopatología de la Obesidad y la Nutrición (CIBERobn), 15706 Santiago de Compostela, SpainCIBER Fisiopatología de la Obesidad y la Nutrición (CIBERobn), 15706 Santiago de Compostela, SpainCIBER Fisiopatología de la Obesidad y la Nutrición (CIBERobn), 15706 Santiago de Compostela, SpainCIBER Fisiopatología de la Obesidad y la Nutrición (CIBERobn), 15706 Santiago de Compostela, SpainCIBER Fisiopatología de la Obesidad y la Nutrición (CIBERobn), 15706 Santiago de Compostela, SpainCenter for Genomic Regulation (CRG), 08003 Barcelona, SpainCIBER Fisiopatología de la Obesidad y la Nutrición (CIBERobn), 15706 Santiago de Compostela, SpainCIBER Fisiopatología de la Obesidad y la Nutrición (CIBERobn), 15706 Santiago de Compostela, SpainCIBER Fisiopatología de la Obesidad y la Nutrición (CIBERobn), 15706 Santiago de Compostela, SpainCIBER Fisiopatología de la Obesidad y la Nutrición (CIBERobn), 15706 Santiago de Compostela, SpainCIBER Fisiopatología de la Obesidad y la Nutrición (CIBERobn), 15706 Santiago de Compostela, SpainCIBER Fisiopatología de la Obesidad y la Nutrición (CIBERobn), 15706 Santiago de Compostela, SpainCIBER Fisiopatología de la Obesidad y la Nutrición (CIBERobn), 15706 Santiago de Compostela, SpainCIBER Fisiopatología de la Obesidad y la Nutrición (CIBERobn), 15706 Santiago de Compostela, SpainLaboratory of Molecular and Cellular Endocrinology, Health Research Institute of Santiago (IDIS), University Hospital of Santiago (XXIS/SERGAS) and Santiago de Compostela University (USC), 15706 Santiago de Compostela, SpainFNDC5/irisin has been recently postulated as beneficial in the treatment of obesity and diabetes because it is induced in muscle by exercise, increasing energy expenditure. However, recent reports have shown that WAT also secretes irisin and that circulating irisin is elevated in obese subjects. The aim of this study was to evaluate irisin levels in conditions of extreme BMI and its correlation with basal metabolism and daily activity. The study involved 145 female patients, including 96 with extreme BMIs (30 anorexic (AN) and 66 obese (OB)) and 49 healthy normal weight (NW). The plasma irisin levels were significantly elevated in the OB patients compared with the AN and NW patients. Irisin also correlated positively with body weight, BMI, and fat mass. The OB patients exhibited the highest REE and higher daily physical activity compared with the AN patients but lower activity compared with the NW patients. The irisin levels were inversely correlated with daily physical activity and directly correlated with REE. Fat mass contributed to most of the variability of the irisin plasma levels independently of the other studied parameters. Conclusion. Irisin levels are influenced by energy expenditure independently of daily physical activity but fat mass is the main contributing factor.http://dx.doi.org/10.1155/2014/857270 |
| spellingShingle | María Pardo Ana B. Crujeiras María Amil Zaida Aguera Susana Jiménez-Murcia Rosa Baños Cristina Botella Rafael de la Torre Xavier Estivill Ana B. Fagundo Jose M. Fernández-Real José C. Fernández-García Gema Fruhbeck Javier Gómez-Ambrosi Roser Rodríguez Francisco J. Tinahones Fernando Fernández-Aranda Felipe F. Casanueva Association of Irisin with Fat Mass, Resting Energy Expenditure, and Daily Activity in Conditions of Extreme Body Mass Index International Journal of Endocrinology |
| title | Association of Irisin with Fat Mass, Resting Energy Expenditure, and Daily Activity in Conditions of Extreme Body Mass Index |
| title_full | Association of Irisin with Fat Mass, Resting Energy Expenditure, and Daily Activity in Conditions of Extreme Body Mass Index |
| title_fullStr | Association of Irisin with Fat Mass, Resting Energy Expenditure, and Daily Activity in Conditions of Extreme Body Mass Index |
| title_full_unstemmed | Association of Irisin with Fat Mass, Resting Energy Expenditure, and Daily Activity in Conditions of Extreme Body Mass Index |
| title_short | Association of Irisin with Fat Mass, Resting Energy Expenditure, and Daily Activity in Conditions of Extreme Body Mass Index |
| title_sort | association of irisin with fat mass resting energy expenditure and daily activity in conditions of extreme body mass index |
| url | http://dx.doi.org/10.1155/2014/857270 |
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