Immune-neuroendocrine reactivity and features of tuberculosis in pregnancy
The combination of tuberculosis and pregnancy always raises questions about therapy, the specialness of management of pregnancy, obstetrics, postpartum period, and lactation; the effect of therapy on fetal development and the peculiarities of the tuberculosis course. Until recently, tuberculosis and...
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| Format: | Article |
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Frontiers Media S.A.
2025-02-01
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| Series: | Frontiers in Medicine |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fmed.2025.1503402/full |
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| author | Anna Starshinova Anna Starshinova Leonid P. Churilov Igor Kudryavtsev Igor Kudryavtsev Artem Rubinstein Artem Rubinstein Ekaterina Belyaeva Anastasia Kulpina Anastasia Kulpina Hong Ling Min Zhuang Dmitry Kudlay Dmitry Kudlay Dmitry Kudlay |
| author_facet | Anna Starshinova Anna Starshinova Leonid P. Churilov Igor Kudryavtsev Igor Kudryavtsev Artem Rubinstein Artem Rubinstein Ekaterina Belyaeva Anastasia Kulpina Anastasia Kulpina Hong Ling Min Zhuang Dmitry Kudlay Dmitry Kudlay Dmitry Kudlay |
| author_sort | Anna Starshinova |
| collection | DOAJ |
| description | The combination of tuberculosis and pregnancy always raises questions about therapy, the specialness of management of pregnancy, obstetrics, postpartum period, and lactation; the effect of therapy on fetal development and the peculiarities of the tuberculosis course. Until recently, tuberculosis and pregnancy were considered a rare combination, but with the growing problem of HIV infection and worsening tuberculosis screening among adults, this combination has become quite common. Moreover, cases of congenital tuberculosis in newborns have begun to emerge. In this review, we analyzed features of immunologic and immuno-neuroendocrine reactivity in pregnant women that influence for prevalence TB and TB/HIV coinfection. The immuno-neuroendocrine changes characteristic of pregnancy have a multifactorial effect on antituberculosis immunity and determine the specificity of the course of tuberculosis against the background of pregnancy. These changes contribute to a more severe course of TB than before pregnancy. The structure of TB clinical forms in women who became ill during pregnancy and in the first year after childbirth is characterized by greater severity, higher frequency of multi-organ lesions, and the percentage of bacterial isolates is significantly higher among women with TB that developed in the postpartum period compared to women who developed it during pregnancy. HIV infection poses a particular threat, exacerbating immune response disorders that affect the effectiveness of treatment and disease progression in general. |
| format | Article |
| id | doaj-art-e4b11e8cd9cf4efa82591716f0768fcd |
| institution | Kabale University |
| issn | 2296-858X |
| language | English |
| publishDate | 2025-02-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Medicine |
| spelling | doaj-art-e4b11e8cd9cf4efa82591716f0768fcd2025-02-06T08:52:32ZengFrontiers Media S.A.Frontiers in Medicine2296-858X2025-02-011210.3389/fmed.2025.15034021503402Immune-neuroendocrine reactivity and features of tuberculosis in pregnancyAnna Starshinova0Anna Starshinova1Leonid P. Churilov2Igor Kudryavtsev3Igor Kudryavtsev4Artem Rubinstein5Artem Rubinstein6Ekaterina Belyaeva7Anastasia Kulpina8Anastasia Kulpina9Hong Ling10Min Zhuang11Dmitry Kudlay12Dmitry Kudlay13Dmitry Kudlay14Saint Petersburg State University, Saint Petersburg, RussiaAlmazov National Medical Research Centre, Saint Petersburg, RussiaSaint Petersburg State University, Saint Petersburg, RussiaAlmazov National Medical Research Centre, Saint Petersburg, RussiaDepartment of Immunology, Institution of Experimental Medicine, Saint Petersburg, RussiaAlmazov National Medical Research Centre, Saint Petersburg, RussiaDepartment of Immunology, Institution of Experimental Medicine, Saint Petersburg, RussiaSaint Petersburg State University, Saint Petersburg, RussiaSaint Petersburg State University, Saint Petersburg, RussiaAlmazov National Medical Research Centre, Saint Petersburg, RussiaHarbin Medical University, Harbin, ChinaHarbin Medical University, Harbin, ChinaI.M. Sechenov First Moscow State Medical University, Moscow, RussiaInstitute of Immunology FMBA of Russia, Moscow, RussiaLomonosov Moscow State University, Moscow, RussiaThe combination of tuberculosis and pregnancy always raises questions about therapy, the specialness of management of pregnancy, obstetrics, postpartum period, and lactation; the effect of therapy on fetal development and the peculiarities of the tuberculosis course. Until recently, tuberculosis and pregnancy were considered a rare combination, but with the growing problem of HIV infection and worsening tuberculosis screening among adults, this combination has become quite common. Moreover, cases of congenital tuberculosis in newborns have begun to emerge. In this review, we analyzed features of immunologic and immuno-neuroendocrine reactivity in pregnant women that influence for prevalence TB and TB/HIV coinfection. The immuno-neuroendocrine changes characteristic of pregnancy have a multifactorial effect on antituberculosis immunity and determine the specificity of the course of tuberculosis against the background of pregnancy. These changes contribute to a more severe course of TB than before pregnancy. The structure of TB clinical forms in women who became ill during pregnancy and in the first year after childbirth is characterized by greater severity, higher frequency of multi-organ lesions, and the percentage of bacterial isolates is significantly higher among women with TB that developed in the postpartum period compared to women who developed it during pregnancy. HIV infection poses a particular threat, exacerbating immune response disorders that affect the effectiveness of treatment and disease progression in general.https://www.frontiersin.org/articles/10.3389/fmed.2025.1503402/fulltuberculosisTB/HIVcoinfection in pregnant womenimmune responseneuroendocrine reactivity |
| spellingShingle | Anna Starshinova Anna Starshinova Leonid P. Churilov Igor Kudryavtsev Igor Kudryavtsev Artem Rubinstein Artem Rubinstein Ekaterina Belyaeva Anastasia Kulpina Anastasia Kulpina Hong Ling Min Zhuang Dmitry Kudlay Dmitry Kudlay Dmitry Kudlay Immune-neuroendocrine reactivity and features of tuberculosis in pregnancy Frontiers in Medicine tuberculosis TB/HIV coinfection in pregnant women immune response neuroendocrine reactivity |
| title | Immune-neuroendocrine reactivity and features of tuberculosis in pregnancy |
| title_full | Immune-neuroendocrine reactivity and features of tuberculosis in pregnancy |
| title_fullStr | Immune-neuroendocrine reactivity and features of tuberculosis in pregnancy |
| title_full_unstemmed | Immune-neuroendocrine reactivity and features of tuberculosis in pregnancy |
| title_short | Immune-neuroendocrine reactivity and features of tuberculosis in pregnancy |
| title_sort | immune neuroendocrine reactivity and features of tuberculosis in pregnancy |
| topic | tuberculosis TB/HIV coinfection in pregnant women immune response neuroendocrine reactivity |
| url | https://www.frontiersin.org/articles/10.3389/fmed.2025.1503402/full |
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