Enhancement of superoxide dismutase gene expression in mice following the administration of cinnamon bark extract
Proliferation of free radicals in the body, particularly in the form of reactive oxygen species (ROS), induces oxidative stress. One can enhance the antioxidant levels in the body by ingesting antioxidant substances. The cinnamon bark (Cinnamomum zeylanicum) is rich in flavonoids, cinnamic acid deri...
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| Format: | Article |
| Language: | English |
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EDP Sciences
2025-01-01
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| Series: | BIO Web of Conferences |
| Online Access: | https://www.bio-conferences.org/articles/bioconf/pdf/2025/05/bioconf_icgrc2025_03007.pdf |
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| author | Ahda Yuni Rahma Mustika Nilasari Ratna Lyrawati Diana |
| author_facet | Ahda Yuni Rahma Mustika Nilasari Ratna Lyrawati Diana |
| author_sort | Ahda Yuni |
| collection | DOAJ |
| description | Proliferation of free radicals in the body, particularly in the form of reactive oxygen species (ROS), induces oxidative stress. One can enhance the antioxidant levels in the body by ingesting antioxidant substances. The cinnamon bark (Cinnamomum zeylanicum) is rich in flavonoids, cinnamic acid derivatives, coumarins, and polyfunctional organic acids. These compounds can serve as significant antioxidants in neutralizing radicals. The objective of this study was to investigate the impact of cinnamon extract on the expression of the superoxidase dismutase (SOD) gene in hepatocytes and spermatozoa of male mice. The treatments included: C: no administration of cinnamon extract, T1: administration of cinnamon extract at a concentration of 75 mg/kgBW, T2: administration of cinnamon extract at a concentration of 150 mg/kgBW. The amount of SOD cDNA after cinnamon extract administration was quantified using quantitative real-time PCR with β-Actin as internal control. This study shows that cinnamon extract (Cinnamomum zeylanicum) had a statistically significant effect (p < 0.05) on the upregulation of the superoxidase dismutase (SOD) gene expression in sperm (3.44) as well as liver cells (3,73) of male mice. The optimal dosage is 150 mg/kg body weight. |
| format | Article |
| id | doaj-art-e4abe10752644b069cfa120271732ac8 |
| institution | Kabale University |
| issn | 2117-4458 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | EDP Sciences |
| record_format | Article |
| series | BIO Web of Conferences |
| spelling | doaj-art-e4abe10752644b069cfa120271732ac82025-02-05T10:43:07ZengEDP SciencesBIO Web of Conferences2117-44582025-01-011540300710.1051/bioconf/202515403007bioconf_icgrc2025_03007Enhancement of superoxide dismutase gene expression in mice following the administration of cinnamon bark extractAhda Yuni0Rahma Mustika1Nilasari Ratna2Lyrawati Diana3Biology Department, Faculty of Mathematics and Natural Sciences, Universitas NegeriBiology Department, Faculty of Mathematics and Natural Sciences, Universitas NegeriBiology Department, Faculty of Mathematics and Natural Sciences, Universitas NegeriPharmacy Department, Faculty of Medicine, Universitas BrawijayaProliferation of free radicals in the body, particularly in the form of reactive oxygen species (ROS), induces oxidative stress. One can enhance the antioxidant levels in the body by ingesting antioxidant substances. The cinnamon bark (Cinnamomum zeylanicum) is rich in flavonoids, cinnamic acid derivatives, coumarins, and polyfunctional organic acids. These compounds can serve as significant antioxidants in neutralizing radicals. The objective of this study was to investigate the impact of cinnamon extract on the expression of the superoxidase dismutase (SOD) gene in hepatocytes and spermatozoa of male mice. The treatments included: C: no administration of cinnamon extract, T1: administration of cinnamon extract at a concentration of 75 mg/kgBW, T2: administration of cinnamon extract at a concentration of 150 mg/kgBW. The amount of SOD cDNA after cinnamon extract administration was quantified using quantitative real-time PCR with β-Actin as internal control. This study shows that cinnamon extract (Cinnamomum zeylanicum) had a statistically significant effect (p < 0.05) on the upregulation of the superoxidase dismutase (SOD) gene expression in sperm (3.44) as well as liver cells (3,73) of male mice. The optimal dosage is 150 mg/kg body weight.https://www.bio-conferences.org/articles/bioconf/pdf/2025/05/bioconf_icgrc2025_03007.pdf |
| spellingShingle | Ahda Yuni Rahma Mustika Nilasari Ratna Lyrawati Diana Enhancement of superoxide dismutase gene expression in mice following the administration of cinnamon bark extract BIO Web of Conferences |
| title | Enhancement of superoxide dismutase gene expression in mice following the administration of cinnamon bark extract |
| title_full | Enhancement of superoxide dismutase gene expression in mice following the administration of cinnamon bark extract |
| title_fullStr | Enhancement of superoxide dismutase gene expression in mice following the administration of cinnamon bark extract |
| title_full_unstemmed | Enhancement of superoxide dismutase gene expression in mice following the administration of cinnamon bark extract |
| title_short | Enhancement of superoxide dismutase gene expression in mice following the administration of cinnamon bark extract |
| title_sort | enhancement of superoxide dismutase gene expression in mice following the administration of cinnamon bark extract |
| url | https://www.bio-conferences.org/articles/bioconf/pdf/2025/05/bioconf_icgrc2025_03007.pdf |
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