Diosgenin protects against cationic bovine serum albumin-induced membranous glomerulonephritis by attenuating oxidative stress and renal inflammation via the NF-κB pathway

Diosgenin protects against cationic bovine serum albumin-induced membranous glomerulonephritis by attenuating oxidative stress and renal inflammation via the NF-κB pathway

Context Membranous glomerulonephritis (MGN) is a leading cause of nephrotic syndrome in adults. Diosgenin (DG) has been reported to exert antioxidative and anti-inflammatory effects.Objective To investigate the renoprotective activity of DG in a cationic bovine serum albumin-induced rat model of MGN...

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Bibliographic Details
Main Authors: Shiyan Jia, Ruihua Si, Guangzhen Liu, Qiming Zhong
Format: Article
Language:English
Published: Taylor & Francis Group 2024-12-01
Series:Pharmaceutical Biology
Subjects:
Chronic kidney disease
podocyte
traditional Chinese medicine
Nrf2/Keap1 signalling pathway
Online Access:https://www.tandfonline.com/doi/10.1080/13880209.2024.2330602
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