Characteristics of primary biliary cirrhosis in British Columbia's First Nations population

Primary biliary cirrhosis (PBC) is a rare, autoimmune liver disorder characterized by progressive destruction of intrahepatic bile ducts, that results in portal inflammation, scarring, cirrhosis and, eventually, liver failure. Although considered rare in Canadian populations, it is the leading indic...

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Main Authors: Laura Arbour, Rosemarie Rupps, Leigh Field, Paul Ross, Anders Erikson, Harvey Henderson, Warren Hill, Eric M Yoshida
Format: Article
Language:English
Published: Wiley 2005-01-01
Series:Canadian Journal of Gastroenterology
Online Access:http://dx.doi.org/10.1155/2005/203028
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author Laura Arbour
Rosemarie Rupps
Leigh Field
Paul Ross
Anders Erikson
Harvey Henderson
Warren Hill
Eric M Yoshida
author_facet Laura Arbour
Rosemarie Rupps
Leigh Field
Paul Ross
Anders Erikson
Harvey Henderson
Warren Hill
Eric M Yoshida
author_sort Laura Arbour
collection DOAJ
description Primary biliary cirrhosis (PBC) is a rare, autoimmune liver disorder characterized by progressive destruction of intrahepatic bile ducts, that results in portal inflammation, scarring, cirrhosis and, eventually, liver failure. Although considered rare in Canadian populations, it is the leading indication for referral for liver transplantation in British Columbia's First Nations population. Previously, an expanded review of all cases referred to the British Columbia Transplant Society for PBC was carried out comparing the demographics of those of First Nations descent with those not of First Nations descent. The review suggested that the rate of referral for transplantation was eight times higher for those of First Nations descent compared with those of other descent (P=0.0001), and a disproportionate number of the First Nations cases lived on Vancouver Island (48% of cases versus 18% expected, P<0.05). Additionally, the age of referral was significantly younger (45.9 versus 54.3 years) for those of First Nations descent and there are fewer First Nations men referred (1:34) than expected. For the purpose of the present report, 28 symptomatic cases were ascertained separately and reviewed in a clinical study to delineate the features of this population.
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publishDate 2005-01-01
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series Canadian Journal of Gastroenterology
spelling doaj-art-e4a5d6396a864c9494f8b752d36c1ba02025-02-03T06:11:41ZengWileyCanadian Journal of Gastroenterology0835-79002005-01-0119530531010.1155/2005/203028Characteristics of primary biliary cirrhosis in British Columbia's First Nations populationLaura Arbour0Rosemarie Rupps1Leigh Field2Paul Ross3Anders Erikson4Harvey HendersonWarren Hill5Eric M Yoshida6Department of Genetics, University of British Columbia, CanadaDepartment of Genetics, University of British Columbia, CanadaDepartment of Genetics, University of British Columbia, CanadaBritish Columbia Transplant Society, Vancouver, CanadaDivision of Medical Genetics, Department of Pathology, Victoria General Hospital, Victoria, CanadaCentre for Disease Control, CanadaBritish Columbia Transplant Society, Vancouver, CanadaPrimary biliary cirrhosis (PBC) is a rare, autoimmune liver disorder characterized by progressive destruction of intrahepatic bile ducts, that results in portal inflammation, scarring, cirrhosis and, eventually, liver failure. Although considered rare in Canadian populations, it is the leading indication for referral for liver transplantation in British Columbia's First Nations population. Previously, an expanded review of all cases referred to the British Columbia Transplant Society for PBC was carried out comparing the demographics of those of First Nations descent with those not of First Nations descent. The review suggested that the rate of referral for transplantation was eight times higher for those of First Nations descent compared with those of other descent (P=0.0001), and a disproportionate number of the First Nations cases lived on Vancouver Island (48% of cases versus 18% expected, P<0.05). Additionally, the age of referral was significantly younger (45.9 versus 54.3 years) for those of First Nations descent and there are fewer First Nations men referred (1:34) than expected. For the purpose of the present report, 28 symptomatic cases were ascertained separately and reviewed in a clinical study to delineate the features of this population.http://dx.doi.org/10.1155/2005/203028
spellingShingle Laura Arbour
Rosemarie Rupps
Leigh Field
Paul Ross
Anders Erikson
Harvey Henderson
Warren Hill
Eric M Yoshida
Characteristics of primary biliary cirrhosis in British Columbia's First Nations population
Canadian Journal of Gastroenterology
title Characteristics of primary biliary cirrhosis in British Columbia's First Nations population
title_full Characteristics of primary biliary cirrhosis in British Columbia's First Nations population
title_fullStr Characteristics of primary biliary cirrhosis in British Columbia's First Nations population
title_full_unstemmed Characteristics of primary biliary cirrhosis in British Columbia's First Nations population
title_short Characteristics of primary biliary cirrhosis in British Columbia's First Nations population
title_sort characteristics of primary biliary cirrhosis in british columbia s first nations population
url http://dx.doi.org/10.1155/2005/203028
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