Screening for Cushing Syndrome at the Primary Care Level: What Every General Practitioner Must Know
Cushing’s syndrome is a rare entity, and a high index of suspicion is needed for screening in a primary care setting. The clinical awareness of the primary care physician (PCP) to the highly indicative signs and symptoms such as facial plethora, proximal myopathy, reddish purple striae, and easy bru...
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| Format: | Article |
| Language: | English |
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Wiley
2017-01-01
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| Series: | International Journal of Endocrinology |
| Online Access: | http://dx.doi.org/10.1155/2017/1547358 |
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| author | Ernest Yorke Yacoba Atiase Josephine Akpalu Osei Sarfo-Kantanka |
| author_facet | Ernest Yorke Yacoba Atiase Josephine Akpalu Osei Sarfo-Kantanka |
| author_sort | Ernest Yorke |
| collection | DOAJ |
| description | Cushing’s syndrome is a rare entity, and a high index of suspicion is needed for screening in a primary care setting. The clinical awareness of the primary care physician (PCP) to the highly indicative signs and symptoms such as facial plethora, proximal myopathy, reddish purple striae, and easy bruisability should alert him to look for biochemical evidence of Cushing’s syndrome through any of the first-line screening tests, namely, 24-hour urinary free cortisol, overnight dexamethasone suppression test, or late-night salivary cortisol. Commonly used random cortisol measurements are unreliable; hence, general practitioners are encouraged to understand the use of these more reliable tests with increased sensitivity and specificity for screening Cushing’s syndrome. In this write-up, we set out to increase awareness about the presentation of Cushing’s syndrome and current recommended screening methods as well as their strengths and weaknesses. We relied mainly on the recommendations by the Endocrine Society Guidelines. |
| format | Article |
| id | doaj-art-e497e52722e84789b3824e6d49f3d2b1 |
| institution | Kabale University |
| issn | 1687-8337 1687-8345 |
| language | English |
| publishDate | 2017-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Endocrinology |
| spelling | doaj-art-e497e52722e84789b3824e6d49f3d2b12025-02-03T05:47:14ZengWileyInternational Journal of Endocrinology1687-83371687-83452017-01-01201710.1155/2017/15473581547358Screening for Cushing Syndrome at the Primary Care Level: What Every General Practitioner Must KnowErnest Yorke0Yacoba Atiase1Josephine Akpalu2Osei Sarfo-Kantanka3Endocrine & Diabetes Unit, Department of Medicine and Therapeutics, School of Medicine and Dentistry, College of Health Sciences, University of Ghana, Legon, Accra, GhanaEndocrine & Diabetes Unit, Department of Medicine and Therapeutics, School of Medicine and Dentistry, College of Health Sciences, University of Ghana, Legon, Accra, GhanaEndocrine & Diabetes Unit, Department of Medicine and Therapeutics, School of Medicine and Dentistry, College of Health Sciences, University of Ghana, Legon, Accra, GhanaDirectorate of Medicine, Endocrine and Diabetes Unit, Komfo Anokye Teaching Hospital, Kumasi, GhanaCushing’s syndrome is a rare entity, and a high index of suspicion is needed for screening in a primary care setting. The clinical awareness of the primary care physician (PCP) to the highly indicative signs and symptoms such as facial plethora, proximal myopathy, reddish purple striae, and easy bruisability should alert him to look for biochemical evidence of Cushing’s syndrome through any of the first-line screening tests, namely, 24-hour urinary free cortisol, overnight dexamethasone suppression test, or late-night salivary cortisol. Commonly used random cortisol measurements are unreliable; hence, general practitioners are encouraged to understand the use of these more reliable tests with increased sensitivity and specificity for screening Cushing’s syndrome. In this write-up, we set out to increase awareness about the presentation of Cushing’s syndrome and current recommended screening methods as well as their strengths and weaknesses. We relied mainly on the recommendations by the Endocrine Society Guidelines.http://dx.doi.org/10.1155/2017/1547358 |
| spellingShingle | Ernest Yorke Yacoba Atiase Josephine Akpalu Osei Sarfo-Kantanka Screening for Cushing Syndrome at the Primary Care Level: What Every General Practitioner Must Know International Journal of Endocrinology |
| title | Screening for Cushing Syndrome at the Primary Care Level: What Every General Practitioner Must Know |
| title_full | Screening for Cushing Syndrome at the Primary Care Level: What Every General Practitioner Must Know |
| title_fullStr | Screening for Cushing Syndrome at the Primary Care Level: What Every General Practitioner Must Know |
| title_full_unstemmed | Screening for Cushing Syndrome at the Primary Care Level: What Every General Practitioner Must Know |
| title_short | Screening for Cushing Syndrome at the Primary Care Level: What Every General Practitioner Must Know |
| title_sort | screening for cushing syndrome at the primary care level what every general practitioner must know |
| url | http://dx.doi.org/10.1155/2017/1547358 |
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