Impact of Periodontitis and Oral Dysbiosis Metabolites in the Modulation of Accelerating Ageing and Human Senescence
Periodontitis, a chronic multifactorial inflammatory condition of the periodontium, is originated by a dysbiotic oral microbiota and is negatively correlated with several systemic diseases. The low-chronic burden of gingival inflammation not only exacerbates periodontitis but also predisposes indivi...
Saved in:
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2025-01-01
|
| Series: | Metabolites |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2218-1989/15/1/35 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832588027400028160 |
|---|---|
| author | Mariacristina Amato Alessandro Polizzi Gaia Viglianisi Francesco Leonforte Marco Mascitti Gaetano Isola |
| author_facet | Mariacristina Amato Alessandro Polizzi Gaia Viglianisi Francesco Leonforte Marco Mascitti Gaetano Isola |
| author_sort | Mariacristina Amato |
| collection | DOAJ |
| description | Periodontitis, a chronic multifactorial inflammatory condition of the periodontium, is originated by a dysbiotic oral microbiota and is negatively correlated with several systemic diseases. The low-chronic burden of gingival inflammation not only exacerbates periodontitis but also predisposes individuals to a spectrum of age-related conditions, including cardiovascular diseases, neurodegenerative disorders, and metabolic dysfunction, especially related to ageing. In this regard, over the local periodontal treatment, lifestyle modifications and adjunctive therapies may offer synergistic benefits in ameliorating both oral and systemic health in ageing populations. Elucidating the intricate connections between periodontitis and senescence is important for understanding oral health’s systemic implications for ageing and age-related diseases. Effective management strategies targeting the oral microbiota and senescent pathways may offer novel avenues for promoting healthy ageing and preventing age-related morbidities. This review will analyze the current literature about the intricate interplay between periodontitis, oral dysbiosis, and the processes of senescence, shedding light on their collective impact on the modulation and accelerated ageing and age-related diseases. Lastly, therapeutic strategies targeting periodontitis and oral dysbiosis to mitigate senescence and its associated morbidities will be discussed. |
| format | Article |
| id | doaj-art-e48776b083244a0bbd7b600923211141 |
| institution | Kabale University |
| issn | 2218-1989 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Metabolites |
| spelling | doaj-art-e48776b083244a0bbd7b6009232111412025-01-24T13:41:14ZengMDPI AGMetabolites2218-19892025-01-011513510.3390/metabo15010035Impact of Periodontitis and Oral Dysbiosis Metabolites in the Modulation of Accelerating Ageing and Human SenescenceMariacristina Amato0Alessandro Polizzi1Gaia Viglianisi2Francesco Leonforte3Marco Mascitti4Gaetano Isola5Department of General Surgery and Surgical-Medical Specialties, School of Dentistry, University of Catania, 95124 Catania, ItalyDepartment of General Surgery and Surgical-Medical Specialties, School of Dentistry, University of Catania, 95124 Catania, ItalyDepartment of General Surgery and Surgical-Medical Specialties, School of Dentistry, University of Catania, 95124 Catania, ItalyHygiene Unit, Department of Medical and Surgical Sciences and Advanced Technologies, University of Catania, 95124 Catania, ItalyDepartment of Clinical Specialistic and Dental Sciences, Marche Polytechnic University, 60121 Ancona, ItalyDepartment of General Surgery and Surgical-Medical Specialties, School of Dentistry, University of Catania, 95124 Catania, ItalyPeriodontitis, a chronic multifactorial inflammatory condition of the periodontium, is originated by a dysbiotic oral microbiota and is negatively correlated with several systemic diseases. The low-chronic burden of gingival inflammation not only exacerbates periodontitis but also predisposes individuals to a spectrum of age-related conditions, including cardiovascular diseases, neurodegenerative disorders, and metabolic dysfunction, especially related to ageing. In this regard, over the local periodontal treatment, lifestyle modifications and adjunctive therapies may offer synergistic benefits in ameliorating both oral and systemic health in ageing populations. Elucidating the intricate connections between periodontitis and senescence is important for understanding oral health’s systemic implications for ageing and age-related diseases. Effective management strategies targeting the oral microbiota and senescent pathways may offer novel avenues for promoting healthy ageing and preventing age-related morbidities. This review will analyze the current literature about the intricate interplay between periodontitis, oral dysbiosis, and the processes of senescence, shedding light on their collective impact on the modulation and accelerated ageing and age-related diseases. Lastly, therapeutic strategies targeting periodontitis and oral dysbiosis to mitigate senescence and its associated morbidities will be discussed.https://www.mdpi.com/2218-1989/15/1/35ageingimmune responseinflammationmetabolitesmouthoral dysbiosis |
| spellingShingle | Mariacristina Amato Alessandro Polizzi Gaia Viglianisi Francesco Leonforte Marco Mascitti Gaetano Isola Impact of Periodontitis and Oral Dysbiosis Metabolites in the Modulation of Accelerating Ageing and Human Senescence Metabolites ageing immune response inflammation metabolites mouth oral dysbiosis |
| title | Impact of Periodontitis and Oral Dysbiosis Metabolites in the Modulation of Accelerating Ageing and Human Senescence |
| title_full | Impact of Periodontitis and Oral Dysbiosis Metabolites in the Modulation of Accelerating Ageing and Human Senescence |
| title_fullStr | Impact of Periodontitis and Oral Dysbiosis Metabolites in the Modulation of Accelerating Ageing and Human Senescence |
| title_full_unstemmed | Impact of Periodontitis and Oral Dysbiosis Metabolites in the Modulation of Accelerating Ageing and Human Senescence |
| title_short | Impact of Periodontitis and Oral Dysbiosis Metabolites in the Modulation of Accelerating Ageing and Human Senescence |
| title_sort | impact of periodontitis and oral dysbiosis metabolites in the modulation of accelerating ageing and human senescence |
| topic | ageing immune response inflammation metabolites mouth oral dysbiosis |
| url | https://www.mdpi.com/2218-1989/15/1/35 |
| work_keys_str_mv | AT mariacristinaamato impactofperiodontitisandoraldysbiosismetabolitesinthemodulationofacceleratingageingandhumansenescence AT alessandropolizzi impactofperiodontitisandoraldysbiosismetabolitesinthemodulationofacceleratingageingandhumansenescence AT gaiaviglianisi impactofperiodontitisandoraldysbiosismetabolitesinthemodulationofacceleratingageingandhumansenescence AT francescoleonforte impactofperiodontitisandoraldysbiosismetabolitesinthemodulationofacceleratingageingandhumansenescence AT marcomascitti impactofperiodontitisandoraldysbiosismetabolitesinthemodulationofacceleratingageingandhumansenescence AT gaetanoisola impactofperiodontitisandoraldysbiosismetabolitesinthemodulationofacceleratingageingandhumansenescence |