Iatrogenic cerebral amyloid angiopathy and Alzheimer's disease co‐pathology
Abstract Iatrogenic cerebral amyloid angiopathy, a disease caused by contact with neurosurgical material or human growth hormone contaminated by beta‐amyloid peptide (Aβ), has a prion‐like transmission mechanism. We present a series of three patients under 55 years of age who underwent cranial surge...
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| Format: | Article |
| Language: | English |
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Wiley
2025-01-01
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| Series: | Annals of Clinical and Translational Neurology |
| Online Access: | https://doi.org/10.1002/acn3.52278 |
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| author | Francisco Hernández‐Fernández Isabel Martínez‐Fernández Rosa Barbella‐Aponte Inmaculada Feria Vilar Oscar Ayo‐Martín Jorge García‐García Rosa Collado Alberto Andrés Mar Hernández‐Guillamón Francisco José Pena Pardo Cristina Barrena Miguel de laFuente Gemma Serrano‐Heras María Melero Elena Lozano Setién Luis López Tomás Segura |
| author_facet | Francisco Hernández‐Fernández Isabel Martínez‐Fernández Rosa Barbella‐Aponte Inmaculada Feria Vilar Oscar Ayo‐Martín Jorge García‐García Rosa Collado Alberto Andrés Mar Hernández‐Guillamón Francisco José Pena Pardo Cristina Barrena Miguel de laFuente Gemma Serrano‐Heras María Melero Elena Lozano Setién Luis López Tomás Segura |
| author_sort | Francisco Hernández‐Fernández |
| collection | DOAJ |
| description | Abstract Iatrogenic cerebral amyloid angiopathy, a disease caused by contact with neurosurgical material or human growth hormone contaminated by beta‐amyloid peptide (Aβ), has a prion‐like transmission mechanism. We present a series of three patients under 55 years of age who underwent cranial surgery. All of them developed multiple cerebral hemorrhages, transient focal neurological deficits, and/or cognitive impairment after 3–4 decades. MRI was compatible with CAA, and Aβ deposition was confirmed. The third patient, who had a ventriculoperitoneal valve, also showed Aβ deposition in the peritoneum and diagnostic biomarkers of Alzheimer's disease. Co‐pathology with Alzheimer disease and its iatrogenic transmission should be considered. |
| format | Article |
| id | doaj-art-e482a0c34a5041dfb41235784890c0f2 |
| institution | Kabale University |
| issn | 2328-9503 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Annals of Clinical and Translational Neurology |
| spelling | doaj-art-e482a0c34a5041dfb41235784890c0f22025-01-21T05:41:43ZengWileyAnnals of Clinical and Translational Neurology2328-95032025-01-0112123524110.1002/acn3.52278Iatrogenic cerebral amyloid angiopathy and Alzheimer's disease co‐pathologyFrancisco Hernández‐Fernández0Isabel Martínez‐Fernández1Rosa Barbella‐Aponte2Inmaculada Feria Vilar3Oscar Ayo‐Martín4Jorge García‐García5Rosa Collado6Alberto Andrés7Mar Hernández‐Guillamón8Francisco José Pena Pardo9Cristina Barrena10Miguel de laFuente11Gemma Serrano‐Heras12María Melero13Elena Lozano Setién14Luis López15Tomás Segura16Neurology Department Albacete Universitary Hospital Albacete SpainNeurology Department Albacete Universitary Hospital Albacete SpainPathology Department Albacete Universitary Hospital Albacete SpainNeurology Department Albacete Universitary Hospital Albacete SpainNeurology Department Albacete Universitary Hospital Albacete SpainNeurology Department Albacete Universitary Hospital Albacete SpainRadiology Department Albacete Universitary Hospital Albacete SpainNeurology Department Albacete Universitary Hospital Albacete SpainResearch Unit Vall d'Hebron Universitary Hospital Barcelona SpainNuclear Medicine Department Ciudad Real Universitary Hospital Ciudad Real SpainNeurosurgery Department Albacete Universitary Hospital Albacete SpainRadiology Department Albacete Universitary Hospital Albacete SpainResearch Unit Albacete Universitary Hospital Albacete SpainInternal Medicine Department Albacete Universitary Hospital Albacete SpainRadiology Department Albacete Universitary Hospital Albacete SpainNeurology Department Vigo Universitary Hospital Vigo SpainNeurology Department Albacete Universitary Hospital Albacete SpainAbstract Iatrogenic cerebral amyloid angiopathy, a disease caused by contact with neurosurgical material or human growth hormone contaminated by beta‐amyloid peptide (Aβ), has a prion‐like transmission mechanism. We present a series of three patients under 55 years of age who underwent cranial surgery. All of them developed multiple cerebral hemorrhages, transient focal neurological deficits, and/or cognitive impairment after 3–4 decades. MRI was compatible with CAA, and Aβ deposition was confirmed. The third patient, who had a ventriculoperitoneal valve, also showed Aβ deposition in the peritoneum and diagnostic biomarkers of Alzheimer's disease. Co‐pathology with Alzheimer disease and its iatrogenic transmission should be considered.https://doi.org/10.1002/acn3.52278 |
| spellingShingle | Francisco Hernández‐Fernández Isabel Martínez‐Fernández Rosa Barbella‐Aponte Inmaculada Feria Vilar Oscar Ayo‐Martín Jorge García‐García Rosa Collado Alberto Andrés Mar Hernández‐Guillamón Francisco José Pena Pardo Cristina Barrena Miguel de laFuente Gemma Serrano‐Heras María Melero Elena Lozano Setién Luis López Tomás Segura Iatrogenic cerebral amyloid angiopathy and Alzheimer's disease co‐pathology Annals of Clinical and Translational Neurology |
| title | Iatrogenic cerebral amyloid angiopathy and Alzheimer's disease co‐pathology |
| title_full | Iatrogenic cerebral amyloid angiopathy and Alzheimer's disease co‐pathology |
| title_fullStr | Iatrogenic cerebral amyloid angiopathy and Alzheimer's disease co‐pathology |
| title_full_unstemmed | Iatrogenic cerebral amyloid angiopathy and Alzheimer's disease co‐pathology |
| title_short | Iatrogenic cerebral amyloid angiopathy and Alzheimer's disease co‐pathology |
| title_sort | iatrogenic cerebral amyloid angiopathy and alzheimer s disease co pathology |
| url | https://doi.org/10.1002/acn3.52278 |
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