Gut Microbiota in Chronic Inflammatory Diseases - Literature Review
Introduction The gut microbiota, a complex community of microorganisms residing in the human gastrointestinal tract, is integral to various bodily functions. Understanding the role of gut microbiota is essential due to its significant influence on human health and disease. Current research in...
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| Format: | Article |
| Language: | English |
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Kazimierz Wielki University
2025-03-01
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| Series: | Journal of Education, Health and Sport |
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| Online Access: | https://apcz.umk.pl/JEHS/article/view/58307 |
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| author | Joanna Zygadło Kamila Jałocha Piotr Bakuła |
| author_facet | Joanna Zygadło Kamila Jałocha Piotr Bakuła |
| author_sort | Joanna Zygadło |
| collection | DOAJ |
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Introduction
The gut microbiota, a complex community of microorganisms residing in the human gastrointestinal tract, is integral to various bodily functions.
Understanding the role of gut microbiota is essential due to its significant influence on human health and disease. Current research indicates that gut microbiota can modulate immune responses and maintain homeostasis.
Despite extensive studies, the specific mechanisms by which gut microbiota influences chronic inflammatory diseases remain unclear.
Investigating the interaction between gut microbiota and the immune system can provide new insights into potential therapeutic strategies for chronic inflammatory diseases.
Aim of the study
This study aims to elucidate the mechanisms by which gut microbiota affects immune responses, particularly in chronic inflammatory conditions. We hypothesize that alterations in gut microbiota composition can significantly modulate immune responses, thereby influencing the progression of chronic inflammatory diseases.
Conclusions
We discuss potential therapeutic interventions targeting the gut microbiota for chronic inflammatory diseases that encompass several approaches. These include the administration of probiotics and prebiotics, fecal microbiota transplantation (FMT), diverse dietary modifications. Personalized microbiome-based therapies offer tailored interventions that combine various methodologies. Further scientific investigation is necessary to comprehensively elucidate and optimize these therapeutic strategies.
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| format | Article |
| id | doaj-art-e47039a7efc04df1a7b4173f78edbf4b |
| institution | DOAJ |
| issn | 2391-8306 |
| language | English |
| publishDate | 2025-03-01 |
| publisher | Kazimierz Wielki University |
| record_format | Article |
| series | Journal of Education, Health and Sport |
| spelling | doaj-art-e47039a7efc04df1a7b4173f78edbf4b2025-08-20T03:16:19ZengKazimierz Wielki UniversityJournal of Education, Health and Sport2391-83062025-03-017910.12775/JEHS.2025.79.58307Gut Microbiota in Chronic Inflammatory Diseases - Literature ReviewJoanna Zygadło0https://orcid.org/0000-0001-5377-5254Kamila Jałocha1https://orcid.org/0009-0003-5734-5261Piotr Bakuła2https://orcid.org/0009-0002-8066-5688Faculty of Medicine, Medical University of WarsawMedical University of Warsaw, Żwirki i Wigury 61, 02-091 Warsaw, Poland Międzyleski Specialist Hospital in Warsaw, Bursztynowa 2, 04-749 Warsaw, Poland Introduction The gut microbiota, a complex community of microorganisms residing in the human gastrointestinal tract, is integral to various bodily functions. Understanding the role of gut microbiota is essential due to its significant influence on human health and disease. Current research indicates that gut microbiota can modulate immune responses and maintain homeostasis. Despite extensive studies, the specific mechanisms by which gut microbiota influences chronic inflammatory diseases remain unclear. Investigating the interaction between gut microbiota and the immune system can provide new insights into potential therapeutic strategies for chronic inflammatory diseases. Aim of the study This study aims to elucidate the mechanisms by which gut microbiota affects immune responses, particularly in chronic inflammatory conditions. We hypothesize that alterations in gut microbiota composition can significantly modulate immune responses, thereby influencing the progression of chronic inflammatory diseases. Conclusions We discuss potential therapeutic interventions targeting the gut microbiota for chronic inflammatory diseases that encompass several approaches. These include the administration of probiotics and prebiotics, fecal microbiota transplantation (FMT), diverse dietary modifications. Personalized microbiome-based therapies offer tailored interventions that combine various methodologies. Further scientific investigation is necessary to comprehensively elucidate and optimize these therapeutic strategies. https://apcz.umk.pl/JEHS/article/view/58307Gut microbiotachronic inflammationinflammatory bowel diseasesmicrobial dysregulationtherapeutic strategies |
| spellingShingle | Joanna Zygadło Kamila Jałocha Piotr Bakuła Gut Microbiota in Chronic Inflammatory Diseases - Literature Review Journal of Education, Health and Sport Gut microbiota chronic inflammation inflammatory bowel diseases microbial dysregulation therapeutic strategies |
| title | Gut Microbiota in Chronic Inflammatory Diseases - Literature Review |
| title_full | Gut Microbiota in Chronic Inflammatory Diseases - Literature Review |
| title_fullStr | Gut Microbiota in Chronic Inflammatory Diseases - Literature Review |
| title_full_unstemmed | Gut Microbiota in Chronic Inflammatory Diseases - Literature Review |
| title_short | Gut Microbiota in Chronic Inflammatory Diseases - Literature Review |
| title_sort | gut microbiota in chronic inflammatory diseases literature review |
| topic | Gut microbiota chronic inflammation inflammatory bowel diseases microbial dysregulation therapeutic strategies |
| url | https://apcz.umk.pl/JEHS/article/view/58307 |
| work_keys_str_mv | AT joannazygadło gutmicrobiotainchronicinflammatorydiseasesliteraturereview AT kamilajałocha gutmicrobiotainchronicinflammatorydiseasesliteraturereview AT piotrbakuła gutmicrobiotainchronicinflammatorydiseasesliteraturereview |