Voxel-Wise Brain-Wide Functional Connectivity Abnormalities in Patients with Primary Blepharospasm at Rest
Background. Primary blepharospasm (BSP) is one of the most common focal dystonia and its pathophysiological mechanism remains unclear. An unbiased method was used in patients with BSP at rest to observe voxel-wise brain-wide functional connectivity (FC) changes. Method. A total of 48 subjects, inclu...
Saved in:
| Main Authors: | , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2021-01-01
|
| Series: | Neural Plasticity |
| Online Access: | http://dx.doi.org/10.1155/2021/6611703 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832563252579532800 |
|---|---|
| author | Pan Pan Shubao Wei Huabing Li Yangpan Ou Feng Liu Wenyan Jiang Wenmei Li Yiwu Lei Yanqing Tang Wenbin Guo Shuguang Luo |
| author_facet | Pan Pan Shubao Wei Huabing Li Yangpan Ou Feng Liu Wenyan Jiang Wenmei Li Yiwu Lei Yanqing Tang Wenbin Guo Shuguang Luo |
| author_sort | Pan Pan |
| collection | DOAJ |
| description | Background. Primary blepharospasm (BSP) is one of the most common focal dystonia and its pathophysiological mechanism remains unclear. An unbiased method was used in patients with BSP at rest to observe voxel-wise brain-wide functional connectivity (FC) changes. Method. A total of 48 subjects, including 24 untreated patients with BSP and 24 healthy controls, were recruited to undergo functional magnetic resonance imaging (fMRI). The method of global-brain FC (GFC) was adopted to analyze the resting-state fMRI data. We designed the support vector machine (SVM) method to determine whether GFC abnormalities could be utilized to distinguish the patients from the controls. Results. Relative to healthy controls, patients with BSP showed significantly decreased GFC in the bilateral superior medial prefrontal cortex/anterior cingulate cortex (MPFC/ACC) and increased GFC in the right postcentral gyrus/precentral gyrus/paracentral lobule, right superior frontal gyrus (SFG), and left paracentral lobule/supplement motor area (SMA), which were included in the default mode network (DMN) and sensorimotor network. SVM analysis showed that increased GFC values in the right postcentral gyrus/precentral gyrus/paracentral lobule could discriminate patients from controls with optimal accuracy, specificity, and sensitivity of 83.33%, 83.33%, and 83.33%, respectively. Conclusion. This study suggested that abnormal GFC in the brain areas associated with sensorimotor network and DMN might underlie the pathophysiology of BSP, which provided a new perspective to understand BSP. GFC in the right postcentral gyrus/precentral gyrus/paracentral lobule might be utilized as a latent biomarker to differentiate patients with BSP from controls. |
| format | Article |
| id | doaj-art-e4676480baa64e7d99f2c5033a7b6f07 |
| institution | Kabale University |
| issn | 2090-5904 1687-5443 |
| language | English |
| publishDate | 2021-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Neural Plasticity |
| spelling | doaj-art-e4676480baa64e7d99f2c5033a7b6f072025-02-03T01:20:38ZengWileyNeural Plasticity2090-59041687-54432021-01-01202110.1155/2021/66117036611703Voxel-Wise Brain-Wide Functional Connectivity Abnormalities in Patients with Primary Blepharospasm at RestPan Pan0Shubao Wei1Huabing Li2Yangpan Ou3Feng Liu4Wenyan Jiang5Wenmei Li6Yiwu Lei7Yanqing Tang8Wenbin Guo9Shuguang Luo10National Clinical Research Center for Mental Disorders, and Department of Psychiatry, The Second Xiangya Hospital of Central South University, Changsha, 410011 Hunan, ChinaDepartment of Neurology, The First Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi 530021, ChinaDepartment of Radiology, The Second Xiangya Hospital of Central South University, Changsha, 410011 Hunan, ChinaNational Clinical Research Center for Mental Disorders, and Department of Psychiatry, The Second Xiangya Hospital of Central South University, Changsha, 410011 Hunan, ChinaDepartment of Radiology, Tianjin Medical University General Hospital, Tianjin 300000, ChinaDepartment of Neurology, The First Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi 530021, ChinaDepartment of Neurology, The First Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi 530021, ChinaDepartment of Neurology, The First Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi 530021, ChinaDepartment of Psychiatry, The First Affiliated Hospital of China Medical University, Shenyang, Liaoning 110001, ChinaNational Clinical Research Center for Mental Disorders, and Department of Psychiatry, The Second Xiangya Hospital of Central South University, Changsha, 410011 Hunan, ChinaDepartment of Neurology, The First Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi 530021, ChinaBackground. Primary blepharospasm (BSP) is one of the most common focal dystonia and its pathophysiological mechanism remains unclear. An unbiased method was used in patients with BSP at rest to observe voxel-wise brain-wide functional connectivity (FC) changes. Method. A total of 48 subjects, including 24 untreated patients with BSP and 24 healthy controls, were recruited to undergo functional magnetic resonance imaging (fMRI). The method of global-brain FC (GFC) was adopted to analyze the resting-state fMRI data. We designed the support vector machine (SVM) method to determine whether GFC abnormalities could be utilized to distinguish the patients from the controls. Results. Relative to healthy controls, patients with BSP showed significantly decreased GFC in the bilateral superior medial prefrontal cortex/anterior cingulate cortex (MPFC/ACC) and increased GFC in the right postcentral gyrus/precentral gyrus/paracentral lobule, right superior frontal gyrus (SFG), and left paracentral lobule/supplement motor area (SMA), which were included in the default mode network (DMN) and sensorimotor network. SVM analysis showed that increased GFC values in the right postcentral gyrus/precentral gyrus/paracentral lobule could discriminate patients from controls with optimal accuracy, specificity, and sensitivity of 83.33%, 83.33%, and 83.33%, respectively. Conclusion. This study suggested that abnormal GFC in the brain areas associated with sensorimotor network and DMN might underlie the pathophysiology of BSP, which provided a new perspective to understand BSP. GFC in the right postcentral gyrus/precentral gyrus/paracentral lobule might be utilized as a latent biomarker to differentiate patients with BSP from controls.http://dx.doi.org/10.1155/2021/6611703 |
| spellingShingle | Pan Pan Shubao Wei Huabing Li Yangpan Ou Feng Liu Wenyan Jiang Wenmei Li Yiwu Lei Yanqing Tang Wenbin Guo Shuguang Luo Voxel-Wise Brain-Wide Functional Connectivity Abnormalities in Patients with Primary Blepharospasm at Rest Neural Plasticity |
| title | Voxel-Wise Brain-Wide Functional Connectivity Abnormalities in Patients with Primary Blepharospasm at Rest |
| title_full | Voxel-Wise Brain-Wide Functional Connectivity Abnormalities in Patients with Primary Blepharospasm at Rest |
| title_fullStr | Voxel-Wise Brain-Wide Functional Connectivity Abnormalities in Patients with Primary Blepharospasm at Rest |
| title_full_unstemmed | Voxel-Wise Brain-Wide Functional Connectivity Abnormalities in Patients with Primary Blepharospasm at Rest |
| title_short | Voxel-Wise Brain-Wide Functional Connectivity Abnormalities in Patients with Primary Blepharospasm at Rest |
| title_sort | voxel wise brain wide functional connectivity abnormalities in patients with primary blepharospasm at rest |
| url | http://dx.doi.org/10.1155/2021/6611703 |
| work_keys_str_mv | AT panpan voxelwisebrainwidefunctionalconnectivityabnormalitiesinpatientswithprimaryblepharospasmatrest AT shubaowei voxelwisebrainwidefunctionalconnectivityabnormalitiesinpatientswithprimaryblepharospasmatrest AT huabingli voxelwisebrainwidefunctionalconnectivityabnormalitiesinpatientswithprimaryblepharospasmatrest AT yangpanou voxelwisebrainwidefunctionalconnectivityabnormalitiesinpatientswithprimaryblepharospasmatrest AT fengliu voxelwisebrainwidefunctionalconnectivityabnormalitiesinpatientswithprimaryblepharospasmatrest AT wenyanjiang voxelwisebrainwidefunctionalconnectivityabnormalitiesinpatientswithprimaryblepharospasmatrest AT wenmeili voxelwisebrainwidefunctionalconnectivityabnormalitiesinpatientswithprimaryblepharospasmatrest AT yiwulei voxelwisebrainwidefunctionalconnectivityabnormalitiesinpatientswithprimaryblepharospasmatrest AT yanqingtang voxelwisebrainwidefunctionalconnectivityabnormalitiesinpatientswithprimaryblepharospasmatrest AT wenbinguo voxelwisebrainwidefunctionalconnectivityabnormalitiesinpatientswithprimaryblepharospasmatrest AT shuguangluo voxelwisebrainwidefunctionalconnectivityabnormalitiesinpatientswithprimaryblepharospasmatrest |