Phosphatidylserine-decorated delivery platform helps alleviate acute lung injury via potentiating macrophage targeting
Acute lung injury (ALI) is a life-threatening inflammatory disease with high morbidity and mortality. It is urgent to develop more effective therapeutic strategies against ALI. Phosphatidylserine (PtdSer) expressed on the surface of apoptotic cells not only allows for macrophage binding and recognit...
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| Format: | Article |
| Language: | English |
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Elsevier
2025-05-01
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| Series: | Journal of Lipid Research |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S0022227525000598 |
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| author | Yue Li Hu Li Zhiwei Hu Yayue Zhang Xuran Ding Xinjie Huang Yabing Hua Lin Sun Ye Li Ziming Zhao Yuan He |
| author_facet | Yue Li Hu Li Zhiwei Hu Yayue Zhang Xuran Ding Xinjie Huang Yabing Hua Lin Sun Ye Li Ziming Zhao Yuan He |
| author_sort | Yue Li |
| collection | DOAJ |
| description | Acute lung injury (ALI) is a life-threatening inflammatory disease with high morbidity and mortality. It is urgent to develop more effective therapeutic strategies against ALI. Phosphatidylserine (PtdSer) expressed on the surface of apoptotic cells not only allows for macrophage binding and recognition but also drives anti-inflammatory signaling within the macrophage. In this study, we designed an apoptotic cell-mimicry nanoparticle by decorating synthetic PtdSer on the outer face of nanoparticles. The results indicated that PtdSer-decorated poly(lactic-co-glycolic acid) nanoparticles (PSNPs) showed anti-inflammatory properties and increased macrophage phagocytosis in relative to the nondecorated poly(lactic-co-glycolic acid nanoparticles. Dexamethasone-loaded PSNPs exhibited superior anti-inflammatory activity on macrophages in vitro. In vivo studies also showed that PtdSer decoration increased the accumulation of nanoparticles in lung macrophages after pulmonary administration. Accumulation of dexamethasone-loaded PSNPs in lung macrophages effectively reduced inflammation in inflamed lungs and further alleviated ALI syndromes. In conclusion, PtdSer decoration not only endows the anti-inflammatory function to nanocarriers but also potentiates its macrophage targeting in the inflamed microenvironment, which offers an ideal drug delivery platform for ALI therapy. |
| format | Article |
| id | doaj-art-e4649ab542024933bdcc486a9e945d77 |
| institution | OA Journals |
| issn | 0022-2275 |
| language | English |
| publishDate | 2025-05-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Journal of Lipid Research |
| spelling | doaj-art-e4649ab542024933bdcc486a9e945d772025-08-20T02:14:24ZengElsevierJournal of Lipid Research0022-22752025-05-0166510079910.1016/j.jlr.2025.100799Phosphatidylserine-decorated delivery platform helps alleviate acute lung injury via potentiating macrophage targetingYue Li0Hu Li1Zhiwei Hu2Yayue Zhang3Xuran Ding4Xinjie Huang5Yabing Hua6Lin Sun7Ye Li8Ziming Zhao9Yuan He10School of Medical Technology, Xuzhou Medical University, Xuzhou, Jiangsu, ChinaSchool of Pharmacy, Xuzhou Medical University, Xuzhou, Jiangsu, ChinaThe Second Clinical Medical School, Xuzhou Medical University, Xuzhou, Jiangsu, ChinaSchool of Pharmacy, Xuzhou Medical University, Xuzhou, Jiangsu, ChinaSchool of Pharmacy, Xuzhou Medical University, Xuzhou, Jiangsu, ChinaSchool of Pharmacy, Xuzhou Medical University, Xuzhou, Jiangsu, ChinaSchool of Pharmacy, Xuzhou Medical University, Xuzhou, Jiangsu, ChinaDepartment of Zhuhai Campus of Zunyi Medical University, Zhuhai, ChinaThe Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, Guangdong, ChinaSchool of Pharmacy, Xuzhou Medical University, Xuzhou, Jiangsu, China; For correspondence: Ziming Zhao; Yuan HeSchool of Pharmacy, Xuzhou Medical University, Xuzhou, Jiangsu, China; For correspondence: Ziming Zhao; Yuan HeAcute lung injury (ALI) is a life-threatening inflammatory disease with high morbidity and mortality. It is urgent to develop more effective therapeutic strategies against ALI. Phosphatidylserine (PtdSer) expressed on the surface of apoptotic cells not only allows for macrophage binding and recognition but also drives anti-inflammatory signaling within the macrophage. In this study, we designed an apoptotic cell-mimicry nanoparticle by decorating synthetic PtdSer on the outer face of nanoparticles. The results indicated that PtdSer-decorated poly(lactic-co-glycolic acid) nanoparticles (PSNPs) showed anti-inflammatory properties and increased macrophage phagocytosis in relative to the nondecorated poly(lactic-co-glycolic acid nanoparticles. Dexamethasone-loaded PSNPs exhibited superior anti-inflammatory activity on macrophages in vitro. In vivo studies also showed that PtdSer decoration increased the accumulation of nanoparticles in lung macrophages after pulmonary administration. Accumulation of dexamethasone-loaded PSNPs in lung macrophages effectively reduced inflammation in inflamed lungs and further alleviated ALI syndromes. In conclusion, PtdSer decoration not only endows the anti-inflammatory function to nanocarriers but also potentiates its macrophage targeting in the inflamed microenvironment, which offers an ideal drug delivery platform for ALI therapy.http://www.sciencedirect.com/science/article/pii/S0022227525000598phosphatidylserinedecorationmacrophagedelivery platformacute lung injuryapoptotic cell |
| spellingShingle | Yue Li Hu Li Zhiwei Hu Yayue Zhang Xuran Ding Xinjie Huang Yabing Hua Lin Sun Ye Li Ziming Zhao Yuan He Phosphatidylserine-decorated delivery platform helps alleviate acute lung injury via potentiating macrophage targeting Journal of Lipid Research phosphatidylserine decoration macrophage delivery platform acute lung injury apoptotic cell |
| title | Phosphatidylserine-decorated delivery platform helps alleviate acute lung injury via potentiating macrophage targeting |
| title_full | Phosphatidylserine-decorated delivery platform helps alleviate acute lung injury via potentiating macrophage targeting |
| title_fullStr | Phosphatidylserine-decorated delivery platform helps alleviate acute lung injury via potentiating macrophage targeting |
| title_full_unstemmed | Phosphatidylserine-decorated delivery platform helps alleviate acute lung injury via potentiating macrophage targeting |
| title_short | Phosphatidylserine-decorated delivery platform helps alleviate acute lung injury via potentiating macrophage targeting |
| title_sort | phosphatidylserine decorated delivery platform helps alleviate acute lung injury via potentiating macrophage targeting |
| topic | phosphatidylserine decoration macrophage delivery platform acute lung injury apoptotic cell |
| url | http://www.sciencedirect.com/science/article/pii/S0022227525000598 |
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