Evaluation of the Relationship between Early Troponin Clearance and Short-Term Mortality in Patients with Chronic Renal Failure
Objective. In patients with CKD, cTn concentrations may be elevated in the absence of AMI, which is a predicted finding caused by chronic structural heart disease rather than acute injury. The increase in troponin level observed in noncardiac conditions provides conflicting results when predicting m...
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| Format: | Article |
| Language: | English |
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Wiley
2020-01-01
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| Series: | Emergency Medicine International |
| Online Access: | http://dx.doi.org/10.1155/2020/6328037 |
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| _version_ | 1832565961801072640 |
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| author | Ahmet Ozbek Abdullah Algın Gokhan Tas Mehmet Ozgur Erdogan |
| author_facet | Ahmet Ozbek Abdullah Algın Gokhan Tas Mehmet Ozgur Erdogan |
| author_sort | Ahmet Ozbek |
| collection | DOAJ |
| description | Objective. In patients with CKD, cTn concentrations may be elevated in the absence of AMI, which is a predicted finding caused by chronic structural heart disease rather than acute injury. The increase in troponin level observed in noncardiac conditions provides conflicting results when predicting mortality. Low lactate clearance was associated with increased mortality. Lactate clearance is calculated as follows: (early lactate − late lactate/early lactate) ∗ 100. We aimed to investigate whether troponin clearance calculated according to this formula had an effect on short-term mortality. Methods. The study included 300 patients with chronic renal failure who had a sepsis-related organ failure assessment (SOFA) score ≥3. By taking the baseline troponin at the time of emergency presentation as reference and comparing them with the fourth-hour troponin values, troponin clearance was investigated in the evaluation of mortality among hospitalized patients with CKD within the first month after discharge. The data obtained were analyzed using the SPSS data analysis software version 20.0. Student’s t-test was used for the parametric data, and the Chi-squared test for the nonparametric data. Results. Of the 300 patients evaluated, 189 patients survived (mean age 66.20 ± 14.597 years), and 111 died (mean age 74.81 ± 12.916 years). Troponin clearance was detected in 40 of the 111 patients in the mortality group and 119 of the 189 patients in the survival group. Troponin clearance was significantly more frequent in surviving patients (P=0.0000083). Conclusion. Troponin clearance can be considered as a valuable leading indicator of survival, but higher levels of troponin clearance did not lead to higher survival rates. |
| format | Article |
| id | doaj-art-e4619d7b1eaf457a808b0c7d2d0ec616 |
| institution | Kabale University |
| issn | 2090-2840 2090-2859 |
| language | English |
| publishDate | 2020-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Emergency Medicine International |
| spelling | doaj-art-e4619d7b1eaf457a808b0c7d2d0ec6162025-02-03T01:05:29ZengWileyEmergency Medicine International2090-28402090-28592020-01-01202010.1155/2020/63280376328037Evaluation of the Relationship between Early Troponin Clearance and Short-Term Mortality in Patients with Chronic Renal FailureAhmet Ozbek0Abdullah Algın1Gokhan Tas2Mehmet Ozgur Erdogan3Department of Emergency Medicine, University of Health Sciences Sisli Etfal Training and Research Hospital, Istanbul, TurkeyDepartment of Emergency Medicine, University of Health Sciences Umraniye Training and Research Hospital, Istanbul, TurkeyDepartment of Emergency Medicine, Sakarya University Training and Research Hospital, Adapazarı, Sakarya, TurkeyDepartment of Emergency Medicine, Bahcesehir University, Istanbul, TurkeyObjective. In patients with CKD, cTn concentrations may be elevated in the absence of AMI, which is a predicted finding caused by chronic structural heart disease rather than acute injury. The increase in troponin level observed in noncardiac conditions provides conflicting results when predicting mortality. Low lactate clearance was associated with increased mortality. Lactate clearance is calculated as follows: (early lactate − late lactate/early lactate) ∗ 100. We aimed to investigate whether troponin clearance calculated according to this formula had an effect on short-term mortality. Methods. The study included 300 patients with chronic renal failure who had a sepsis-related organ failure assessment (SOFA) score ≥3. By taking the baseline troponin at the time of emergency presentation as reference and comparing them with the fourth-hour troponin values, troponin clearance was investigated in the evaluation of mortality among hospitalized patients with CKD within the first month after discharge. The data obtained were analyzed using the SPSS data analysis software version 20.0. Student’s t-test was used for the parametric data, and the Chi-squared test for the nonparametric data. Results. Of the 300 patients evaluated, 189 patients survived (mean age 66.20 ± 14.597 years), and 111 died (mean age 74.81 ± 12.916 years). Troponin clearance was detected in 40 of the 111 patients in the mortality group and 119 of the 189 patients in the survival group. Troponin clearance was significantly more frequent in surviving patients (P=0.0000083). Conclusion. Troponin clearance can be considered as a valuable leading indicator of survival, but higher levels of troponin clearance did not lead to higher survival rates.http://dx.doi.org/10.1155/2020/6328037 |
| spellingShingle | Ahmet Ozbek Abdullah Algın Gokhan Tas Mehmet Ozgur Erdogan Evaluation of the Relationship between Early Troponin Clearance and Short-Term Mortality in Patients with Chronic Renal Failure Emergency Medicine International |
| title | Evaluation of the Relationship between Early Troponin Clearance and Short-Term Mortality in Patients with Chronic Renal Failure |
| title_full | Evaluation of the Relationship between Early Troponin Clearance and Short-Term Mortality in Patients with Chronic Renal Failure |
| title_fullStr | Evaluation of the Relationship between Early Troponin Clearance and Short-Term Mortality in Patients with Chronic Renal Failure |
| title_full_unstemmed | Evaluation of the Relationship between Early Troponin Clearance and Short-Term Mortality in Patients with Chronic Renal Failure |
| title_short | Evaluation of the Relationship between Early Troponin Clearance and Short-Term Mortality in Patients with Chronic Renal Failure |
| title_sort | evaluation of the relationship between early troponin clearance and short term mortality in patients with chronic renal failure |
| url | http://dx.doi.org/10.1155/2020/6328037 |
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