eNSMBL-PASD: Spearheading early autism spectrum disorder detection through advanced genomic computational frameworks utilizing ensemble learning models
Objective Autism spectrum disorder (ASD) is a complex neurodevelopmental condition influenced by various genetic and environmental factors. Currently, there is no definitive clinical test, such as a blood analysis or brain scan, for early diagnosis. The objective of this study is to develop a comput...
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| Format: | Article |
| Language: | English |
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SAGE Publishing
2025-01-01
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| Series: | Digital Health |
| Online Access: | https://doi.org/10.1177/20552076241313407 |
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| author | Ayesha Karim Nashwan Alromema Sharaf J Malebary Faisal Binzagr Amir Ahmed Yaser Daanial Khan |
| author_facet | Ayesha Karim Nashwan Alromema Sharaf J Malebary Faisal Binzagr Amir Ahmed Yaser Daanial Khan |
| author_sort | Ayesha Karim |
| collection | DOAJ |
| description | Objective Autism spectrum disorder (ASD) is a complex neurodevelopmental condition influenced by various genetic and environmental factors. Currently, there is no definitive clinical test, such as a blood analysis or brain scan, for early diagnosis. The objective of this study is to develop a computational model that predicts ASD driver genes in the early stages using genomic data, aiming to enhance early diagnosis and intervention. Methods This study utilized a benchmark genomic dataset, which was processed using feature extraction techniques to identify relevant genetic patterns. Several ensemble classification methods, including Extreme Gradient Boosting, Random Forest, Light Gradient Boosting Machine, ExtraTrees, and a stacked ensemble of classifiers, were applied to assess the predictive power of the genomic features. TheEnsemble Model Predictor for Autism Spectrum Disorder (eNSMBL-PASD) model was rigorously validated using multiple performance metrics such as accuracy, sensitivity, specificity, and Mathew's correlation coefficient. Results The proposed model demonstrated superior performance across various validation techniques. The self-consistency test achieved 100% accuracy, while the independent set and cross-validation tests yielded 91% and 87% accuracy, respectively. These results highlight the model's robustness and reliability in predicting ASD-related genes. Conclusion The eNSMBL-PASD model provides a promising tool for the early detection of ASD by identifying genetic markers associated with the disorder. In the future, this model has the potential to assist healthcare professionals, particularly doctors and psychologists, in diagnosing and formulating treatment plans for ASD at its earliest stages. |
| format | Article |
| id | doaj-art-e45dae752fb44a899281e550d02f0756 |
| institution | Kabale University |
| issn | 2055-2076 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | SAGE Publishing |
| record_format | Article |
| series | Digital Health |
| spelling | doaj-art-e45dae752fb44a899281e550d02f07562025-01-27T13:03:21ZengSAGE PublishingDigital Health2055-20762025-01-011110.1177/20552076241313407eNSMBL-PASD: Spearheading early autism spectrum disorder detection through advanced genomic computational frameworks utilizing ensemble learning modelsAyesha Karim0Nashwan Alromema1Sharaf J Malebary2Faisal Binzagr3Amir Ahmed4Yaser Daanial Khan5 Department of Computer Science, School of Systems and Technology, , Lahore, Pakistan Department of Computer Science, Faculty of Computing and Information Technology-Rabigh, , Jeddah, Saudi Arabia Department of Information Technology, Faculty of Computing and Information Technology, , Rabigh, Saudi Arabia Department of Computer Science, Faculty of Computing and Information Technology-Rabigh, , Jeddah, Saudi Arabia College of Information Technology, Information Systems and Security, , Alain, United Arab Emirates Department of Computer Science, School of Systems and Technology, , Lahore, PakistanObjective Autism spectrum disorder (ASD) is a complex neurodevelopmental condition influenced by various genetic and environmental factors. Currently, there is no definitive clinical test, such as a blood analysis or brain scan, for early diagnosis. The objective of this study is to develop a computational model that predicts ASD driver genes in the early stages using genomic data, aiming to enhance early diagnosis and intervention. Methods This study utilized a benchmark genomic dataset, which was processed using feature extraction techniques to identify relevant genetic patterns. Several ensemble classification methods, including Extreme Gradient Boosting, Random Forest, Light Gradient Boosting Machine, ExtraTrees, and a stacked ensemble of classifiers, were applied to assess the predictive power of the genomic features. TheEnsemble Model Predictor for Autism Spectrum Disorder (eNSMBL-PASD) model was rigorously validated using multiple performance metrics such as accuracy, sensitivity, specificity, and Mathew's correlation coefficient. Results The proposed model demonstrated superior performance across various validation techniques. The self-consistency test achieved 100% accuracy, while the independent set and cross-validation tests yielded 91% and 87% accuracy, respectively. These results highlight the model's robustness and reliability in predicting ASD-related genes. Conclusion The eNSMBL-PASD model provides a promising tool for the early detection of ASD by identifying genetic markers associated with the disorder. In the future, this model has the potential to assist healthcare professionals, particularly doctors and psychologists, in diagnosing and formulating treatment plans for ASD at its earliest stages.https://doi.org/10.1177/20552076241313407 |
| spellingShingle | Ayesha Karim Nashwan Alromema Sharaf J Malebary Faisal Binzagr Amir Ahmed Yaser Daanial Khan eNSMBL-PASD: Spearheading early autism spectrum disorder detection through advanced genomic computational frameworks utilizing ensemble learning models Digital Health |
| title | eNSMBL-PASD: Spearheading early autism spectrum disorder detection through advanced genomic computational frameworks utilizing ensemble learning models |
| title_full | eNSMBL-PASD: Spearheading early autism spectrum disorder detection through advanced genomic computational frameworks utilizing ensemble learning models |
| title_fullStr | eNSMBL-PASD: Spearheading early autism spectrum disorder detection through advanced genomic computational frameworks utilizing ensemble learning models |
| title_full_unstemmed | eNSMBL-PASD: Spearheading early autism spectrum disorder detection through advanced genomic computational frameworks utilizing ensemble learning models |
| title_short | eNSMBL-PASD: Spearheading early autism spectrum disorder detection through advanced genomic computational frameworks utilizing ensemble learning models |
| title_sort | ensmbl pasd spearheading early autism spectrum disorder detection through advanced genomic computational frameworks utilizing ensemble learning models |
| url | https://doi.org/10.1177/20552076241313407 |
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