Loss of TLR3 aggravates CHIKV replication and pathology due to an altered virus‐specific neutralizing antibody response

Loss of TLR3 aggravates CHIKV replication and pathology due to an altered virus‐specific neutralizing antibody response

Abstract RNA‐sensing toll‐like receptors (TLRs) mediate innate immunity and regulate anti‐viral response. We show here that TLR3 regulates host immunity and the loss of TLR3 aggravates pathology in Chikungunya virus (CHIKV) infection. Susceptibility to CHIKV infection is markedly increased in human...

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Bibliographic Details
Main Authors: Zhisheng Her, Terk‐Shin Teng, Jeslin JL Tan, Teck‐Hui Teo, Yiu‐Wing Kam, Fok‐Moon Lum, Wendy WL Lee, Christelle Gabriel, Rossella Melchiotti, Anand K Andiappan, Valeria Lulla, Aleksei Lulla, Mar K Win, Angela Chow, Subhra K Biswas, Yee‐Sin Leo, Marc Lecuit, Andres Merits, Laurent Rénia, Lisa FP Ng
Format: Article
Language:English
Published: Springer Nature 2014-12-01
Series:EMBO Molecular Medicine
Subjects:
Chikungunya virus
innate immunity
joint inflammation
neutralizing antibodies
TLR3
Online Access:https://doi.org/10.15252/emmm.201404459
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