Nutritionally physiological cell culture medium and 3D culture influence breast tumour proteomics and anti-cancer drug effectiveness

Nutritionally physiological cell culture medium and 3D culture influence breast tumour proteomics and anti-cancer drug effectiveness

Many drugs have been discontinued during phase II/III breast cancer clinical trials due to lack of clinical efficacy, indicating shortcomings in predictive value of preclinical data. Nutrient availability in the tumour cell microenvironment and the dimensionality of in vitro tumour cells likely impa...

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Bibliographic Details
Main Authors: Xiaodan Zhang, Tianhong Cheng, Ellie Cho, Wenjia Lu, Delphine Denoyer, Paul McMillan, Kalyan Shobhana, Swati Varshney, Nicholas A. Williamson, Alastair Stewart
Format: Article
Language:English
Published: Elsevier 2024-12-01
Series:Pharmacological Research
Subjects:
microphysiological systems
3D cytotoxicity
paclitaxel
tubulin
topoisomerase
Online Access:http://www.sciencedirect.com/science/article/pii/S104366182400464X
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