Immune Checkpoint Inhibitors and Liver Transplantation: Case Report and Review of the Literature
ABSTRACT As immunotherapy is becoming more inevitable in everyday oncology, we are witnessing a higher number of patients who are on immunosuppressive medication but are also candidates for immune checkpoint inhibitors (ICIs) treatment. There have been few case reports and several small retrospectiv...
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| Format: | Article |
| Language: | English |
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Wiley
2025-04-01
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| Series: | Clinical Case Reports |
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| Online Access: | https://doi.org/10.1002/ccr3.70412 |
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| _version_ | 1849709903887728640 |
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| author | Iva Skocilic Alojzije Kosic Ivona Badovinac Tajana Filipec Kanizaj Renata Dobrila Dintinjana Maja Kolak Anamarija Bukovica Sanja Ropac Ivana Mikolasevic |
| author_facet | Iva Skocilic Alojzije Kosic Ivona Badovinac Tajana Filipec Kanizaj Renata Dobrila Dintinjana Maja Kolak Anamarija Bukovica Sanja Ropac Ivana Mikolasevic |
| author_sort | Iva Skocilic |
| collection | DOAJ |
| description | ABSTRACT As immunotherapy is becoming more inevitable in everyday oncology, we are witnessing a higher number of patients who are on immunosuppressive medication but are also candidates for immune checkpoint inhibitors (ICIs) treatment. There have been few case reports and several small retrospective studies investigating the use of ICIs in liver transplant recipients mainly with hepatocellular carcinoma and skin cancer, but there is no report regarding the use of atezolizumab for the treatment of metastatic breast cancer in liver transplant recipients. We are presenting a metastatic breast cancer female patient undergoing both immunosuppressive treatment after liver transplantation due to cryptogenic liver failure and anti‐programmed death ligand 1 (PDL1) medication—atezolizumab whose liver enzymes and tacrolimus level we have monitored intensively through 18 months and is still ongoing. Our patient has not presented with any signs of acute graft rejection and has a regression on follow‐up imaging despite the treatment combination. |
| format | Article |
| id | doaj-art-e44e2cb4939f4cf9b50ef680f2fd9e40 |
| institution | DOAJ |
| issn | 2050-0904 |
| language | English |
| publishDate | 2025-04-01 |
| publisher | Wiley |
| record_format | Article |
| series | Clinical Case Reports |
| spelling | doaj-art-e44e2cb4939f4cf9b50ef680f2fd9e402025-08-20T03:15:05ZengWileyClinical Case Reports2050-09042025-04-01134n/an/a10.1002/ccr3.70412Immune Checkpoint Inhibitors and Liver Transplantation: Case Report and Review of the LiteratureIva Skocilic0Alojzije Kosic1Ivona Badovinac2Tajana Filipec Kanizaj3Renata Dobrila Dintinjana4Maja Kolak5Anamarija Bukovica6Sanja Ropac7Ivana Mikolasevic8Clinical Hospital Center Rijeka Rijeka CroatiaClinical Hospital Center Rijeka Rijeka CroatiaClinical Hospital Center Rijeka Rijeka CroatiaMerkur Clinical Hospital Zagreb CroatiaClinical Hospital Center Rijeka Rijeka CroatiaClinical Hospital Center Rijeka Rijeka CroatiaClinical Hospital Center Rijeka Rijeka CroatiaClinical Hospital Center Rijeka Rijeka CroatiaClinical Hospital Center Rijeka Rijeka CroatiaABSTRACT As immunotherapy is becoming more inevitable in everyday oncology, we are witnessing a higher number of patients who are on immunosuppressive medication but are also candidates for immune checkpoint inhibitors (ICIs) treatment. There have been few case reports and several small retrospective studies investigating the use of ICIs in liver transplant recipients mainly with hepatocellular carcinoma and skin cancer, but there is no report regarding the use of atezolizumab for the treatment of metastatic breast cancer in liver transplant recipients. We are presenting a metastatic breast cancer female patient undergoing both immunosuppressive treatment after liver transplantation due to cryptogenic liver failure and anti‐programmed death ligand 1 (PDL1) medication—atezolizumab whose liver enzymes and tacrolimus level we have monitored intensively through 18 months and is still ongoing. Our patient has not presented with any signs of acute graft rejection and has a regression on follow‐up imaging despite the treatment combination.https://doi.org/10.1002/ccr3.70412atezolizumabbreast cancerimmune checkpoint inhibitorsliver transplantationmalignancy |
| spellingShingle | Iva Skocilic Alojzije Kosic Ivona Badovinac Tajana Filipec Kanizaj Renata Dobrila Dintinjana Maja Kolak Anamarija Bukovica Sanja Ropac Ivana Mikolasevic Immune Checkpoint Inhibitors and Liver Transplantation: Case Report and Review of the Literature Clinical Case Reports atezolizumab breast cancer immune checkpoint inhibitors liver transplantation malignancy |
| title | Immune Checkpoint Inhibitors and Liver Transplantation: Case Report and Review of the Literature |
| title_full | Immune Checkpoint Inhibitors and Liver Transplantation: Case Report and Review of the Literature |
| title_fullStr | Immune Checkpoint Inhibitors and Liver Transplantation: Case Report and Review of the Literature |
| title_full_unstemmed | Immune Checkpoint Inhibitors and Liver Transplantation: Case Report and Review of the Literature |
| title_short | Immune Checkpoint Inhibitors and Liver Transplantation: Case Report and Review of the Literature |
| title_sort | immune checkpoint inhibitors and liver transplantation case report and review of the literature |
| topic | atezolizumab breast cancer immune checkpoint inhibitors liver transplantation malignancy |
| url | https://doi.org/10.1002/ccr3.70412 |
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